#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41594-1	uniprotkb:Q7Z6G3	intact:EBI-14039683|ensembl:ENSP00000306138	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:p41594-1(display_long)|uniprotkb:GRM5(gene name)|psi-mi:GRM5(display_short)|uniprotkb:GPRC1E(gene name synonym)|uniprotkb:MGLUR5(gene name synonym)|uniprotkb:5b(isoform synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14037152|imex:IM-25753-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168959(gene)|ensembl:ENST00000305447(transcript)|intact:EBI-6595175(isoform-parent)	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	-	-	-	figure legend:1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/05	2017/05/05	rogid:/kz6DJ8xJVDQPX6jEYoTGxmAMsw9606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:eKYwUMAnWwbLcYoCxyA7usoHyMs	false	-	sufficient binding region:77-386|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z6G3	uniprotkb:P41594-1	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	intact:EBI-14039683|ensembl:ENSP00000306138	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:p41594-1(display_long)|uniprotkb:GRM5(gene name)|psi-mi:GRM5(display_short)|uniprotkb:GPRC1E(gene name synonym)|uniprotkb:MGLUR5(gene name synonym)|uniprotkb:5b(isoform synonym)	psi-mi:"MI:0096"(pull down)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14037163|imex:IM-25753-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	ensembl:ENSG00000168959(gene)|ensembl:ENST00000305447(transcript)|intact:EBI-6595175(isoform-parent)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:1c and d|antagonist:"Ca(2+)"|comment:Cell membrane fractions from transfected HEK293 cells have been used for pull down|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/05	2017/05/05	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rogid:/kz6DJ8xJVDQPX6jEYoTGxmAMsw9606	rigid:eKYwUMAnWwbLcYoCxyA7usoHyMs	false	sufficient binding region:77-386|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z6G3	uniprotkb:P29274	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	intact:EBI-2902702|ensembl:ENSP00000336630|ensembl:ENSP00000480012|ensembl:ENSP00000481552|ensembl:ENSP00000483102|uniprotkb:B2R7E0	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:aa2ar_human(display_long)|uniprotkb:ADORA2A(gene name)|psi-mi:ADORA2A(display_short)|uniprotkb:ADORA2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14040373|imex:IM-25753-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	ensembl:ENSG00000128271(gene)|ensembl:ENST00000337539(transcript)|ensembl:ENST00000610595(transcript)|ensembl:ENST00000611543(transcript)|ensembl:ENST00000618076(transcript)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007417"(central nervous system development)|go:"GO:0007596"(blood coagulation)|go:"GO:0007600"(sensory perception)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008015"(blood circulation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014057"(positive regulation of acetylcholine secretion, neurotransmission)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031000"(response to caffeine)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035810"(positive regulation of urine volume)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045938"(positive regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001513(Adenosine A2A receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P29274|rcsb pdb:1MMH|rcsb pdb:1UPE|rcsb pdb:2YDO|rcsb pdb:2YDV|rcsb pdb:3EML|rcsb pdb:3PWH|rcsb pdb:3QAK|rcsb pdb:3REY|rcsb pdb:3RFM|rcsb pdb:3UZA|rcsb pdb:3UZC|rcsb pdb:3VG9|rcsb pdb:3VGA|rcsb pdb:4UG2|rcsb pdb:4UHR|rcsb pdb:5G53|rcsb pdb:5IU4|rcsb pdb:5IU7|rcsb pdb:5IU8|rcsb pdb:5IUA|rcsb pdb:5IUB|rcsb pdb:5JTB|rcsb pdb:5K2A|rcsb pdb:5K2B|rcsb pdb:5K2C|rcsb pdb:5K2D|rcsb pdb:5MZJ|rcsb pdb:5MZP|rcsb pdb:5N2R|rcsb pdb:5NLX|rcsb pdb:5NM2|rcsb pdb:5NM4|rcsb pdb:5OLG|rcsb pdb:5OLH|rcsb pdb:5OLO|rcsb pdb:5OLV|rcsb pdb:5OLZ|rcsb pdb:5OM1|rcsb pdb:5OM4|rcsb pdb:4EIY|rcsb pdb:5UIG|rcsb pdb:5UVI|rcsb pdb:5WF5|rcsb pdb:5WF6|rcsb pdb:6AQF|rcsb pdb:6GDG|rcsb pdb:6GT3|rcsb pdb:6JZH|rcsb pdb:6LPJ|rcsb pdb:6LPK|rcsb pdb:6LPL|rcsb pdb:6MH8|rcsb pdb:6PS7|rcsb pdb:6S0L|rcsb pdb:6S0Q|rcsb pdb:6WQA|rcsb pdb:6ZDR|rcsb pdb:6ZDV|rcsb pdb:7ARO|reactome:R-HSA-187024|reactome:R-HSA-417973|reactome:R-HSA-418555|reactome:R-HSA-5683826|reactome:R-HSA-9660821|rcsb pdb:5VRA|refseq:NP_000666.2|refseq:NP_001265426.1|refseq:NP_001265427.1|refseq:NP_001265428.1|refseq:NP_001265429.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:1c|antagonist:"Ca(2+)"|comment:Cell membrane fractions from transfected HEK293 cells have been used for pull down|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/05	2017/05/05	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rogid:3LgXP8J8wfsw4G5kVvY/8vVp4DA9606	rigid:QqxjOK5jEZSj06nBMWlY8hr9Occ	false	sufficient binding region:77-386|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41594	uniprotkb:Q7Z6G3	intact:EBI-6595175|ensembl:ENSP00000306138|uniprotkb:Q6J164	intact:EBI-950070|ensembl:ENSP00000307449|uniprotkb:A2RRG3|uniprotkb:O75547|uniprotkb:Q6ZSK0|uniprotkb:H3BTW2	psi-mi:grm5_human(display_long)|uniprotkb:GRM5(gene name)|psi-mi:GRM5(display_short)|uniprotkb:GPRC1E(gene name synonym)|uniprotkb:MGLUR5(gene name synonym)	psi-mi:neca2_human(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14037189|imex:IM-25753-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168959(gene)|ensembl:ENST00000305447(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006417"(regulation of translation)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:3LMK|rcsb pdb:4OO9|rcsb pdb:5CGC|rcsb pdb:5CGD|rcsb pdb:6N4X|rcsb pdb:6N4Y|rcsb pdb:6N50|rcsb pdb:6N51|rcsb pdb:6N52|reactome:R-HSA-416476|reactome:R-HSA-420499|reactome:R-HSA-6794361|refseq:XP_011541094.1|refseq:NP_000833.1|refseq:NP_001137303.1|refseq:XP_006718891.1|refseq:XP_016873116.1	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039862|mint:Q7Z6G3|refseq:NP_061938.2|refseq:NP_001316678.1	go:"GO:0005886"(plasma membrane)	-	-	figure legend:2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/05/05	2017/05/05	rogid:/kz6DJ8xJVDQPX6jEYoTGxmAMsw9606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:eKYwUMAnWwbLcYoCxyA7usoHyMs	false	yellow fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P41594	uniprotkb:Q7Z6G3-1	intact:EBI-6595175|ensembl:ENSP00000306138|uniprotkb:Q6J164	intact:EBI-14062033|ensembl:ENSP00000307449	psi-mi:grm5_human(display_long)|uniprotkb:GRM5(gene name)|psi-mi:GRM5(display_short)|uniprotkb:GPRC1E(gene name synonym)|uniprotkb:MGLUR5(gene name synonym)	psi-mi:q7z6g3-1(display_long)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)|uniprotkb:EFCBP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14037202|imex:IM-25753-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168959(gene)|ensembl:ENST00000305447(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006417"(regulation of translation)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:3LMK|rcsb pdb:4OO9|rcsb pdb:5CGC|rcsb pdb:5CGD|rcsb pdb:6N4X|rcsb pdb:6N4Y|rcsb pdb:6N50|rcsb pdb:6N51|rcsb pdb:6N52|reactome:R-HSA-416476|reactome:R-HSA-420499|reactome:R-HSA-6794361|refseq:XP_011541094.1|refseq:NP_000833.1|refseq:NP_001137303.1|refseq:XP_006718891.1|refseq:XP_016873116.1	ensembl:ENSG00000103154(gene)|ensembl:ENST00000305202(transcript)|intact:EBI-950070(isoform-parent)	go:"GO:0005886"(plasma membrane)	-	comment:"Two bands of 43 and 39 kDa have been detected;  the latter one is proposed to correspond to a N-terminal shorter NECAB2 protein form potentially derived from alternative translation initiation (not present in UniProt)"	figure legend:3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/05/05	2017/06/28	rogid:/kz6DJ8xJVDQPX6jEYoTGxmAMsw9606	rogid:Op/JNOBupSCF1U3MCeNmJ6gUUrg9606	rigid:+PLczWFQO6a8Y4IxTMKQvc7i+GY	false	yellow fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41594	uniprotkb:Q7Z6G3-2	intact:EBI-6595175|ensembl:ENSP00000306138|uniprotkb:Q6J164	intact:EBI-10172876|ensembl:ENSP00000457354|intact:EBI-14062040	psi-mi:grm5_human(display_long)|uniprotkb:GRM5(gene name)|psi-mi:GRM5(display_short)|uniprotkb:GPRC1E(gene name synonym)|uniprotkb:MGLUR5(gene name synonym)	psi-mi:q7z6g3-2(display_long)|uniprotkb:EFCBP2(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)|uniprotkb:Synaptotagmin-interacting protein 2(gene name synonym)|uniprotkb:NECAB2(gene name)|psi-mi:NECAB2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14037202|imex:IM-25753-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168959(gene)|ensembl:ENST00000305447(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006417"(regulation of translation)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:3LMK|rcsb pdb:4OO9|rcsb pdb:5CGC|rcsb pdb:5CGD|rcsb pdb:6N4X|rcsb pdb:6N4Y|rcsb pdb:6N50|rcsb pdb:6N51|rcsb pdb:6N52|reactome:R-HSA-416476|reactome:R-HSA-420499|reactome:R-HSA-6794361|refseq:XP_011541094.1|refseq:NP_000833.1|refseq:NP_001137303.1|refseq:XP_006718891.1|refseq:XP_016873116.1	ensembl:ENSG00000103154(gene)|ensembl:ENST00000565691(transcript)|uniprotkb:Q7Z6G3-2(isoform-parent)|intact:EBI-950070(isoform-parent)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/05/05	2017/06/28	rogid:/kz6DJ8xJVDQPX6jEYoTGxmAMsw9606	rogid:4S7oIx6h+mKzV3EPxqcfMNqaNko9606	rigid:+PLczWFQO6a8Y4IxTMKQvc7i+GY	false	yellow fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:P31424	uniprotkb:F1LQY6	intact:EBI-2902734	intact:EBI-2905642|intact:EBI-14040585|uniprotkb:Q9ESB4	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:neca2_rat(display_long)|uniprotkb:Necab2(gene name)|psi-mi:Necab2(display_short)|uniprotkb:Efcbp2(gene name synonym)|uniprotkb:Neuronal calcium-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Canela et al. (2009)	pubmed:19694902|imex:IM-25753	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14040602|imex:IM-25753-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424	go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0042984"(regulation of amyloid precursor protein biosynthetic process)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900451"(positive regulation of glutamate receptor signaling pathway)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:1905477"(positive regulation of protein localization to membrane)|rgd:621844|refseq:NP_596906.1|interpro:IPR007138(Antibiotic biosynthesis monooxygenase)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR039862	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus)|taxid:10116(Rattus norvegicus hippocampal neurons)	-	2017/05/05	2017/08/11	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	rogid:JtTP4aCa1aRikEYmsGaBmUrqH/M10116	rigid:Etz9RIzTfRkbTYAVJbPy0L9QY40	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)