#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43353	uniprotkb:P98170	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798188|imex:IM-14998-2|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	flag tag:n-n	mutation decreasing interaction:219-219|mutation decreasing interaction:223-223,219-219|green fluorescent protein tag:n-n|mutation increasing interaction:223-223	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798165|imex:IM-14998-1|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	flag tag:n-n	sufficient binding region:1-431|green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43353	uniprotkb:P98170	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798219|imex:IM-14998-3|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	green fluorescent protein tag:n-n|sufficient binding region:1-431	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798304|imex:IM-14998-7|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	glutathione s tranferase tag:n-n|sufficient binding region:124-256	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NR28-1	uniprotkb:P98170	intact:EBI-15490322|ensembl:ENSP00000442360|ensembl:ENSP00000499058	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:q9nr28-1(display_long)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798327|imex:IM-14998-8|dip:DIP-44971E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-517508(isoform-parent)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000464942(transcript)|ensembl:ENST00000650715(transcript)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:x9zqc8E0VO5ke9U0qiHrGtLXmvY	false	his tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798280|imex:IM-14998-6|dip:DIP-185546E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:4GozLyuPIcAVR+7N/pOU7G8Z5k0	false	glutathione s tranferase tag:n-n	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98170	uniprotkb:Q9Y239	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798280|imex:IM-14998-6|dip:DIP-185546E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	rigid:4GozLyuPIcAVR+7N/pOU7G8Z5k0	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NR28-1	uniprotkb:P98170	intact:EBI-15490322|ensembl:ENSP00000442360|ensembl:ENSP00000499058	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:q9nr28-1(display_long)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798350|imex:IM-14998-9|dip:DIP-44971E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-517508(isoform-parent)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000464942(transcript)|ensembl:ENST00000650715(transcript)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:x9zqc8E0VO5ke9U0qiHrGtLXmvY	false	binding-associated region:56-239|his tag:?-?	mutation disrupting interaction:219-219|mutation disrupting interaction:223-223|mutation disrupting interaction:223-223,219-219|sufficient binding region:124-256|green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798242|imex:IM-14998-4|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	glutathione s tranferase tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43353	uniprotkb:P98170	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798263|imex:IM-14998-5|dip:DIP-185545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P98170	uniprotkb:Q9HC29	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-7445625|uniprotkb:Q96RH5|uniprotkb:Q96RH8|uniprotkb:Q96RH6|uniprotkb:E2JEQ6|intact:MINT-151071|ensembl:ENSP00000300589	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:nod2_human(display_long)|uniprotkb:IBD1(gene name synonym)|uniprotkb:NOD2(gene name)|psi-mi:NOD2(display_short)|uniprotkb:CARD15(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 15(gene name synonym)|uniprotkb:Inflammatory bowel disease protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798387|imex:IM-14998-10|dip:DIP-185547E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_071445.1|refseq:XP_005256141.1|ensembl:ENSG00000167207(gene)|ensembl:ENST00000300589(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002253"(activation of immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002710"(negative regulation of T cell mediated immunity)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0005856"(cytoskeleton)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0005886"(plasma membrane)|go:"GO:0032498"(detection of muramyl dipeptide)|go:"GO:0032500"(muramyl dipeptide binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0006952"(defense response)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0006965"(positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007584"(response to nutrient)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046645"(positive regulation of gamma-delta T cell activation)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060585"(positive regulation of prostaglandin-endoperoxide synthase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9HC29|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:NP_001280486.1|dip:DIP-41998N	psi-mi:"MI:0465"(dip)	-	comment:mint|comment:homomint|function:"Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)"|function:"Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash"|function:"Defects in NOD2 are a cause of susceptibility to Crohn disease (CD) [MIM:266600]. CD is a form of remitting inflammatory bowel disease (IBD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. Crohn disease is commonly classified as autoimmune disease"|function:"Defects in NOD2 are a cause of susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease"|function:"Defects in NOD2 are the cause of early-onset sarcoidosis (EOS) [MIM:609464]. Sarcoidosis is a multiorganic inflammatory disease with unknown etiology, characterized by the histologic features of non-caseating epithelioid granulomas. In childhood, 2 distinct types of sarcoidosis have been described. Usually the disease is detected in older children by chest radiography and the clinical manifestations are characterized by a classical triad of lung, lymph node, and eye involvement, similar to those in adults. In contrast, early-onset sarcoidosis (EOS), which usually appears in those younger than 4 years of age, is quite rare and has a distinct triad of skin, joint, and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, EOS is progressive and in many cases causes severe complications, such as blindness, joint destruction, and visceral involvement"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:cEF3hnDQW90TWXNDH/uqW6/wMhI9606	rigid:6X9gU9QcacIFS2pScm7s5dP0rLM	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Krieg et al. (2009)	pubmed:19667203|doi:10.1073/pnas.0907131106|imex:IM-14998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15798387|imex:IM-14998-10|dip:DIP-185547E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:6X9gU9QcacIFS2pScm7s5dP0rLM	false	glutathione s tranferase tag:n-n	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)