#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13322-3	uniprotkb:Q13322-3	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796157|imex:IM-14292-1|dip:DIP-103116E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rigid:6vVArUjCyqS/Yh8BSv7bfEFQLz8	false	binding-associated region:106-357|mutation disrupting interaction:331-331,232-232,212-212,145-145	binding-associated region:106-357|mutation disrupting interaction:331-331,232-232,212-212,145-145	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03160	uniprotkb:P01111	intact:EBI-7100053|ensembl:ENSMUSP00000019456|uniprotkb:Q3TH55|intact:MINT-4544456	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:grb7_mouse(display_long)|uniprotkb:Grb7(gene name)|psi-mi:Grb7(display_short)|uniprotkb:GRB7 adapter protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor GRB-7(gene name synonym)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796181|imex:IM-14292-2|dip:DIP-103119E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532296.1|ensembl:ENSMUSG00000019312(gene)|ensembl:ENSMUST00000019456(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035032|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q03160|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-210993|reactome:R-MMU-8853659|reactome:R-MMU-9696273|refseq:NP_034476.1|dip:DIP-43965N	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0465"(dip)	function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:ysRuIDlVygsL9Hy9QANXt3OENSc10090	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rigid:VzV/oEbqTx4g7k+RQ90Xcg2S0+o	false	myc tag:n-n	mutation increasing interaction:12-12|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P06213-1	uniprotkb:Q14449	intact:EBI-15558981|ensembl:ENSP00000303830	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796205|imex:IM-14292-3|dip:DIP-72418E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	rigid:/tlIvAnhe/Ic1HY7uTEdWfw1nZg	false	-	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14449	uniprotkb:P01111	intact:EBI-2680889|uniprotkb:B7Z7F9|uniprotkb:Q7Z6I1|ensembl:ENSP00000263915	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	psi-mi:grb14_human(display_long)|uniprotkb:GRB14 adapter protein(gene name synonym)|uniprotkb:GRB14(gene name)|psi-mi:GRB14(display_short)	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796224|imex:IM-14292-4|dip:DIP-103118E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004481.2|refseq:NP_001290351.1|ensembl:ENSG00000115290(gene)|ensembl:ENST00000263915(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035034|interpro:IPR035035|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q14449|rcsb pdb:2AUG|rcsb pdb:2AUH|rcsb pdb:4K81|reactome:R-HSA-210993|go:"GO:0008286"(insulin receptor signaling pathway)|dip:DIP-42605N	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:b3Xtmki3fCyyoRra/IQWuGIQDCU9606	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rigid:GrYSettcdNQmioBBF95DJJCDyHo	false	myc tag:n-n|mutation disrupting interaction:140-140|mutation disrupting interaction:252-252	mutation increasing interaction:12-12|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13322-3	uniprotkb:Q13322-3	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796255|imex:IM-14292-5|dip:DIP-103116E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rigid:6vVArUjCyqS/Yh8BSv7bfEFQLz8	false	binding-associated region:106-357	binding-associated region:106-357	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06213-1	uniprotkb:Q13322-3	intact:EBI-15558981|ensembl:ENSP00000303830	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796273|imex:IM-14292-6|dip:DIP-75996E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rigid:R9IreoWIQ2a45Zxw6Z+jy9eR0iI	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01111	uniprotkb:Q13322-3	intact:EBI-721993|uniprotkb:Q14971|uniprotkb:Q15104|uniprotkb:Q15282|ensembl:ENSP00000358548	intact:EBI-15796145|ensembl:ENSP00000338543|ensembl:ENSP00000381790|ensembl:ENSP00000385189|ensembl:ENSP00000385046|ensembl:ENSP00000385366|ensembl:ENSP00000385544|ensembl:ENSP00000385748|ensembl:ENSP00000495341|ensembl:ENSP00000496245	psi-mi:rasn_human(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:NRAS(gene name)|psi-mi:NRAS(display_short)|uniprotkb:HRAS1(gene name synonym)	psi-mi:q13322-3(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:Gamma(isoform synonym)|uniprotkb:Beta(isoform synonym)|uniprotkb:SV-1(isoform synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Depetris et al. (2009)	pubmed:19648926|doi:10.1038/nsmb.1642|imex:IM-14292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15796294|imex:IM-14292-7|dip:DIP-103117E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002515.1|ensembl:ENSG00000213281(gene)|ensembl:ENST00000369535(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|dip:DIP-1058N|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:P01111|rcsb pdb:2N9C|rcsb pdb:3CON|rcsb pdb:5UHV|rcsb pdb:6E6H|rcsb pdb:6MPP|rcsb pdb:6ULI|rcsb pdb:6ULK|rcsb pdb:6ULN|rcsb pdb:6ULR|rcsb pdb:6UON|rcsb pdb:6WGH|rcsb pdb:6ZIO|rcsb pdb:6ZIR|rcsb pdb:6ZIZ|reactome:R-HSA-112412|reactome:R-HSA-1169092|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-167044|reactome:R-HSA-171007|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2871796|reactome:R-HSA-375165|reactome:R-HSA-442982|reactome:R-HSA-5218921|reactome:R-HSA-5621575|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5658442|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802953|reactome:R-HSA-6802955|reactome:R-HSA-74751|reactome:R-HSA-8849471|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9634635|reactome:R-HSA-9648002|reactome:R-HSA-9649913|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648	ensembl:ENSG00000106070(gene)|ensembl:ENST00000335866(transcript)|ensembl:ENST00000398810(transcript)|ensembl:ENST00000402497(transcript)|ensembl:ENST00000402578(transcript)|ensembl:ENST00000403097(transcript)|ensembl:ENST00000406641(transcript)|ensembl:ENST00000407526(transcript)|ensembl:ENST00000643299(transcript)|ensembl:ENST00000645075(transcript)|intact:EBI-80275(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:Et90BD+t6LnYThbW6ShQge1GRK89606	rogid:OObUQSGgL6OZMbTawm0SRp5ynw09606	rigid:J47N1P6WcmOB4GDEdDQWyRupviM	false	mutation increasing interaction:12-12|ha tag:n-n	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)