#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q969G6	uniprotkb:P19438-1	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	intact:EBI-15795644|ensembl:ENSP00000162749	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:p19438-1(display_long)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:FL-TNFR1(isoform synonym)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795655|imex:IM-21505-2|dip:DIP-191755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|intact:EBI-299451(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:EflkZkr/4V9UG+/TzTIWGJxJGSc	false	-	binding-associated region:331-363	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P19438	uniprotkb:P63000-1	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795623|imex:IM-21505-1|dip:DIP-191762E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:x5XFNOTXHqW8ioJFG8/c7qFoC5M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:P04839	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-6253630|ensembl:ENSP00000367851|uniprotkb:A8K138|uniprotkb:Q2PP16	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:cy24b_human(display_long)|uniprotkb:CYBB(gene name)|psi-mi:CYBB(display_short)|uniprotkb:NOX2(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:NADPH oxidase 2(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase heavy chain subunit(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795623|imex:IM-21505-1|dip:DIP-191762E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR039261|rcsb pdb:3A1F|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|interpro:IPR017938|ensembl:ENSG00000165168(gene)|ensembl:ENST00000378588(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|refseq:NP_000388.2|dip:DIP-42005N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:+QJRbDhthdRaJRoQLhT4tS6nWfs9606	rigid:x5XFNOTXHqW8ioJFG8/c7qFoC5M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q9Y5S8	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-15795558|ensembl:ENSP00000362057|uniprotkb:A8K836|uniprotkb:O95691|uniprotkb:Q2PP02	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:nox1_human(display_long)|uniprotkb:NOX1(gene name)|psi-mi:NOX1(display_short)|uniprotkb:MOX1(gene name synonym)|uniprotkb:NOH1(gene name synonym)|uniprotkb:Mitogenic oxidase 1(gene name synonym)|uniprotkb:NADH/NADPH mitogenic oxidase subunit P65-MOX(gene name synonym)|uniprotkb:NOH-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795623|imex:IM-21505-1|dip:DIP-191762E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	ensembl:ENSG00000007952(gene)|ensembl:ENST00000372966(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042995"(cell projection)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045730"(respiratory burst)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050661"(NADP binding)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0072592"(oxygen metabolic process)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990451"(cellular stress response to acidic pH)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR029650|interpro:IPR039261|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_001258744.1|refseq:NP_008983.2|refseq:NP_039249.1|dip:DIP-60457N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:yI9TBn+QdbQB/ooZz/LleDFpGJc9606	rigid:x5XFNOTXHqW8ioJFG8/c7qFoC5M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:P13498	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795623|imex:IM-21505-1|dip:DIP-191762E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	rigid:x5XFNOTXHqW8ioJFG8/c7qFoC5M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q969G6	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795623|imex:IM-21505-1|dip:DIP-191762E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rigid:x5XFNOTXHqW8ioJFG8/c7qFoC5M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969G6	uniprotkb:P13498	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:"MI:0096"(pull down)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795897|imex:IM-21505-9|dip:DIP-191756E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	rigid:X5p1VbdKEXr0UdUOVEnqf8yZecc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969G6	uniprotkb:P19438	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795897|imex:IM-21505-9|dip:DIP-191756E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:X5p1VbdKEXr0UdUOVEnqf8yZecc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969G6	uniprotkb:P19438	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795759|imex:IM-21505-6|dip:DIP-191755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:EflkZkr/4V9UG+/TzTIWGJxJGSc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61462	uniprotkb:Q8CFV9	intact:EBI-15795776|ensembl:ENSMUSP00000017604|uniprotkb:Q3U820|uniprotkb:Q9CWB9|uniprotkb:Q9D2W2	intact:EBI-15795674|ensembl:ENSMUSP00000025617|uniprotkb:O35471|uniprotkb:O35472|uniprotkb:Q9CQ95	psi-mi:cy24a_mouse(display_long)|uniprotkb:Cyba(gene name)|psi-mi:Cyba(display_short)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:p22-phox(gene name synonym)	psi-mi:rifk_mouse(display_long)|uniprotkb:Rfk(gene name)|psi-mi:Rfk(display_short)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:KOI-4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795862|imex:IM-21505-7|dip:DIP-191761E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|ensembl:ENSMUSG00000006519(gene)|ensembl:ENSMUST00000017604(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001288213.1|refseq:NP_031832.2|dip:DIP-60456N	ensembl:ENSMUSG00000024712(gene)|ensembl:ENSMUST00000025617(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|reactome:R-MMU-196843|refseq:NP_062310.1|dip:DIP-60455N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:Sqox5aGM2G1TXSpKwI1o/tK103A10090	rogid:v8eXiAs2/HuVLNoxuez585ftpFM10090	rigid:SBJ5bW8L2K3/n1o7NyXKAc2WIu0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q15628	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795879|imex:IM-21505-8|dip:DIP-191759E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:z8v/5vMyARfB/52H2c4uDWwsERA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19438	uniprotkb:Q969G6	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795879|imex:IM-21505-8|dip:DIP-191759E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rigid:z8v/5vMyARfB/52H2c4uDWwsERA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13498	uniprotkb:Q969G6	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795721|imex:IM-21505-4|dip:DIP-191760E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rigid:EaXQj5zo8nPAeDb8DrOo0bFH2Qs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13498	uniprotkb:P19438	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795721|imex:IM-21505-4|dip:DIP-191760E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:EaXQj5zo8nPAeDb8DrOo0bFH2Qs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13498	uniprotkb:Q15628	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795721|imex:IM-21505-4|dip:DIP-191760E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:EaXQj5zo8nPAeDb8DrOo0bFH2Qs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25118	uniprotkb:Q3U0V2	intact:EBI-518014|ensembl:ENSMUSP00000032491	intact:EBI-1544032|ensembl:ENSMUSP00000034359	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795703|imex:IM-21505-3|dip:DIP-191758E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	rigid:tDR2t0uC0sK8yQCsYQ+epmubc00	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25118	uniprotkb:Q8CFV9	intact:EBI-518014|ensembl:ENSMUSP00000032491	intact:EBI-15795674|ensembl:ENSMUSP00000025617|uniprotkb:O35471|uniprotkb:O35472|uniprotkb:Q9CQ95	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:rifk_mouse(display_long)|uniprotkb:Rfk(gene name)|psi-mi:Rfk(display_short)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:KOI-4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795703|imex:IM-21505-3|dip:DIP-191758E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	ensembl:ENSMUSG00000024712(gene)|ensembl:ENSMUST00000025617(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|reactome:R-MMU-196843|refseq:NP_062310.1|dip:DIP-60455N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	rogid:v8eXiAs2/HuVLNoxuez585ftpFM10090	rigid:tDR2t0uC0sK8yQCsYQ+epmubc00	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q969G6	uniprotkb:P19438-1	intact:EBI-716872|uniprotkb:Q9NUT7|uniprotkb:Q5JSG9|ensembl:ENSP00000365926	intact:EBI-15795644|ensembl:ENSP00000162749	psi-mi:rifk_human(display_long)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:RFK(gene name)|psi-mi:RFK(display_short)	psi-mi:p19438-1(display_long)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:FL-TNFR1(isoform synonym)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795740|imex:IM-21505-5|dip:DIP-191755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060809.3|ensembl:ENSG00000135002(gene)|ensembl:ENST00000376736(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|rcsb pdb:1NB0|rcsb pdb:1NB9|rcsb pdb:1P4M|rcsb pdb:1Q9S|reactome:R-HSA-196843|dip:DIP-60454N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|intact:EBI-299451(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:YRkJ7Xoia2axGxVDOUiinrXFJuo9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:EflkZkr/4V9UG+/TzTIWGJxJGSc	false	-	sufficient binding region:331-363	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U0V2	uniprotkb:Q8CFV9	intact:EBI-1544032|ensembl:ENSMUSP00000034359	intact:EBI-15795674|ensembl:ENSMUSP00000025617|uniprotkb:O35471|uniprotkb:O35472|uniprotkb:Q9CQ95	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:rifk_mouse(display_long)|uniprotkb:Rfk(gene name)|psi-mi:Rfk(display_short)|uniprotkb:"ATP:riboflavin 5'-phosphotransferase"(gene name synonym)|uniprotkb:Flavokinase(gene name synonym)|uniprotkb:KOI-4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yazdanpanah et al. (2009)	pubmed:19641494|doi:10.1038/nature08206|imex:IM-21505	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15795917|imex:IM-21505-10|dip:DIP-191757E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	ensembl:ENSMUSG00000024712(gene)|ensembl:ENSMUST00000025617(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008531"(riboflavin kinase activity)|go:"GO:0009231"(riboflavin biosynthetic process)|go:"GO:0009398"(FMN biosynthetic process)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR015865(Riboflavin kinase)|interpro:IPR023465|interpro:IPR023468|reactome:R-MMU-196843|refseq:NP_062310.1|dip:DIP-60455N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	rogid:v8eXiAs2/HuVLNoxuez585ftpFM10090	rigid:HX3gdp34uGnIq/UNDHhg12Y4+pk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)