#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O35601 uniprotkb:Q3UUV5 intact:EBI-7353747|uniprotkb:Q9Z2H3|intact:MINT-244320|ensembl:ENSMUSP00000087947 intact:EBI-12602022|ensembl:ENSMUSP00000099443|uniprotkb:Q3TE54|uniprotkb:Q3UUT7|uniprotkb:Q3UUX6 psi-mi:fyb1_mouse(display_long)|uniprotkb:Fyb1(gene name)|psi-mi:Fyb1(display_short)|uniprotkb:Adhesion and degranulation promoting adaptor protein(gene name synonym)|uniprotkb:FYB-120/130(gene name synonym)|uniprotkb:FYN-T-binding protein(gene name synonym)|uniprotkb:Fyb(gene name synonym)|uniprotkb:SLAP-130(gene name synonym)|uniprotkb:SLP-76-associated phosphoprotein(gene name synonym) psi-mi:skap1_mouse(display_long)|uniprotkb:Skap1(gene name)|psi-mi:Skap1(display_short)|uniprotkb:Scap1(gene name synonym)|uniprotkb:Src family-associated phosphoprotein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wang et al. (2009) pubmed:19617540|doi:10.1073/pnas.0900510106|imex:IM-22458 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15793970|imex:IM-22458-1|dip:DIP-196177E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035945.1|refseq:NP_001265198.1|ensembl:ENSMUSG00000022148(gene)|ensembl:ENSMUST00000090461(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008289"(lipid binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR029294|interpro:IPR030635|interpro:IPR035540|interpro:IPR036028|interpro:IPR043443|reactome:R-MMU-202433|reactome:R-MMU-391160|dip:DIP-41350N ensembl:ENSMUSG00000057058(gene)|ensembl:ENSMUST00000103154(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035765|interpro:IPR036028|interpro:IPR037781|refseq:NP_001028358.1|refseq:NP_001171369.1|refseq:NP_001171370.1|dip:DIP-60767N psi-mi:"MI:0465"(dip) comment:mint|function:"Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:6rfpz9eZT3M5F0khbMoHGg+/vEU10090 rogid:qPGuv8JcF2UIJPu2+FH9bva3pxo10090 rigid:bt9AEOZ0OI3oC77tjkS7leRcOzs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)