#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99IB8	uniprotkb:Q99IB8	intact:EBI-6674379	intact:EBI-6674379	psi-mi:polg_hcvjf(display_long)	psi-mi:polg_hcvjf(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Luik et al. (2009)	pubmed:19590017|doi:10.1073/pnas.0905966106|imex:IM-14772	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15793230|imex:IM-14772-1|dip:DIP-103985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rigid:euI91O5j5/EQHw40R2PkcxYBXO8	false	polyprotein fragment:751-813	polyprotein fragment:751-813	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99IB8	uniprotkb:Q99IB8	intact:EBI-6674379	intact:EBI-6674379	psi-mi:polg_hcvjf(display_long)	psi-mi:polg_hcvjf(display_long)	psi-mi:"MI:0030"(cross-linking study)	Luik et al. (2009)	pubmed:19590017|doi:10.1073/pnas.0905966106|imex:IM-14772	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15793266|imex:IM-14772-3|dip:DIP-103985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rigid:euI91O5j5/EQHw40R2PkcxYBXO8	false	polyprotein fragment:751-813	polyprotein fragment:751-813	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q99IB8	uniprotkb:Q99IB8	intact:EBI-6674379	intact:EBI-6674379	psi-mi:polg_hcvjf(display_long)	psi-mi:polg_hcvjf(display_long)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Luik et al. (2009)	pubmed:19590017|doi:10.1073/pnas.0905966106|imex:IM-14772	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15793248|imex:IM-14772-2|dip:DIP-103985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rigid:euI91O5j5/EQHw40R2PkcxYBXO8	false	polyprotein fragment:751-813	polyprotein fragment:751-813	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99IB8	uniprotkb:Q99IB8	intact:EBI-6674379	intact:EBI-6674379	psi-mi:polg_hcvjf(display_long)	psi-mi:polg_hcvjf(display_long)	psi-mi:"MI:0071"(molecular sieving)	Luik et al. (2009)	pubmed:19590017|doi:10.1073/pnas.0905966106|imex:IM-14772	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	taxid:356411(hcvjf)|taxid:356411("Hepatitis C virus genotype 2a (isolate JFH-1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15793284|imex:IM-14772-4|dip:DIP-103985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	reactome:R-HSA-5621480|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039614"(induction by virus of host protein phosphorylation)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0052064"(induction by symbiont of defense-related host reactive oxygen species production)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901397"(positive regulation of transforming growth factor beta2 activation)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903637"(negative regulation of protein insertion into mitochondrial outer membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR024350|interpro:IPR027417|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|rcsb pdb:2KZQ|rcsb pdb:2LIF|rcsb pdb:2LVG|rcsb pdb:2XXD|rcsb pdb:2XYM|rcsb pdb:3I5K|rcsb pdb:4AEP|rcsb pdb:4AEX|rcsb pdb:4E76|rcsb pdb:4E78|rcsb pdb:4E7A|rcsb pdb:4J1V|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|rcsb pdb:4OBC|rcsb pdb:4WT9|rcsb pdb:4WTA|rcsb pdb:4WTC|rcsb pdb:4WTD|rcsb pdb:4WTE|rcsb pdb:4WTF|rcsb pdb:4WTG|rcsb pdb:4WTI|rcsb pdb:4WTJ|rcsb pdb:4WTK|rcsb pdb:4WTL|rcsb pdb:5NPJ|rcsb pdb:5QJ0|rcsb pdb:5QJ1|rcsb pdb:5TWM|rcsb pdb:5UJ2|rcsb pdb:6HT4|rcsb pdb:4WTM|dip:DIP-48925N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rogid:U3v0dDoZ1reYBBS4sW2wBN/LGZk356411	rigid:euI91O5j5/EQHw40R2PkcxYBXO8	false	polyprotein fragment:751-813	polyprotein fragment:751-813	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)