#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P12954 uniprotkb:Q06148 intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W intact:EBI-34047|uniprotkb:Q0P6Z6|uniprotkb:Q0P6Z7|uniprotkb:Q0P707|uniprotkb:D6VYR3|ensemblfungi:YLR265C psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name) psi-mi:nej1_yeast(display_long)|uniprotkb:NEJ1(gene name)|psi-mi:NEJ1(display_short)|uniprotkb:LIF2(gene name synonym)|uniprotkb:YLR265C(locus name) psi-mi:"MI:0018"(two hybrid) Carter et al. (2009) pubmed:19571008|doi:10.1073/pnas.0903869106|imex:IM-14764 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15792132|imex:IM-14764-1|dip:DIP-103976E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954 refseq:NP_013367.1|sgd:S000004255|mint:Q06148|dip:DIP-4776N|ensemblfungi:YLR265C(gene)|ensemblfungi:YLR265C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0035825"(homologous recombination)|go:"GO:0045002"(double-strand break repair via single-strand annealing)|go:"GO:0045027"(DNA end binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR015381(XLF/Cernunnos) psi-mi:"MI:0465"(dip) crc64:AE8061B114C32120 crc64:5E09B5F851CF03B9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292 rogid:K7Q6t345H+Vo/mrcMIVSHonlQ7o559292 rigid:zV4gvK+r3IEz6dM9TqpQ2+8PXR0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P53150 uniprotkb:Q06148 intact:EBI-23865|uniprotkb:E9P953|uniprotkb:D6VU55|ensemblfungi:YGL090W intact:EBI-34047|uniprotkb:Q0P6Z6|uniprotkb:Q0P6Z7|uniprotkb:Q0P707|uniprotkb:D6VYR3|ensemblfungi:YLR265C psi-mi:lif1_yeast(display_long)|uniprotkb:LIF1(gene name)|psi-mi:LIF1(display_short)|uniprotkb:YGL090W(locus name) psi-mi:nej1_yeast(display_long)|uniprotkb:NEJ1(gene name)|psi-mi:NEJ1(display_short)|uniprotkb:LIF2(gene name synonym)|uniprotkb:YLR265C(locus name) psi-mi:"MI:0018"(two hybrid) Carter et al. (2009) pubmed:19571008|doi:10.1073/pnas.0903869106|imex:IM-14764 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15792170|imex:IM-14764-3|dip:DIP-9096E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011425.1|sgd:S000003058|dip:DIP-5477N|mint:P53150|ensemblfungi:YGL090W(gene)|ensemblfungi:YGL090W_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0032807"(DNA ligase IV complex)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR015381(XLF/Cernunnos)|rcsb pdb:1Z56 refseq:NP_013367.1|sgd:S000004255|mint:Q06148|dip:DIP-4776N|ensemblfungi:YLR265C(gene)|ensemblfungi:YLR265C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0035825"(homologous recombination)|go:"GO:0045002"(double-strand break repair via single-strand annealing)|go:"GO:0045027"(DNA end binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR015381(XLF/Cernunnos) psi-mi:"MI:0465"(dip) crc64:5BEDC72059E9996F crc64:5E09B5F851CF03B9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:IwFXSvAvdi5atkVDKt6aufYgKxw559292 rogid:K7Q6t345H+Vo/mrcMIVSHonlQ7o559292 rigid:ZgHdni2tsOM8WzLmBUAFW1uD9RQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53150 uniprotkb:Q06148 intact:EBI-23865|uniprotkb:E9P953|uniprotkb:D6VU55|ensemblfungi:YGL090W intact:EBI-34047|uniprotkb:Q0P6Z6|uniprotkb:Q0P6Z7|uniprotkb:Q0P707|uniprotkb:D6VYR3|ensemblfungi:YLR265C psi-mi:lif1_yeast(display_long)|uniprotkb:LIF1(gene name)|psi-mi:LIF1(display_short)|uniprotkb:YGL090W(locus name) psi-mi:nej1_yeast(display_long)|uniprotkb:NEJ1(gene name)|psi-mi:NEJ1(display_short)|uniprotkb:LIF2(gene name synonym)|uniprotkb:YLR265C(locus name) psi-mi:"MI:0096"(pull down) Carter et al. (2009) pubmed:19571008|doi:10.1073/pnas.0903869106|imex:IM-14764 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15792187|imex:IM-14764-4|dip:DIP-9096E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011425.1|sgd:S000003058|dip:DIP-5477N|mint:P53150|ensemblfungi:YGL090W(gene)|ensemblfungi:YGL090W_mRNA(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0032807"(DNA ligase IV complex)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR015381(XLF/Cernunnos)|rcsb pdb:1Z56 refseq:NP_013367.1|sgd:S000004255|mint:Q06148|dip:DIP-4776N|ensemblfungi:YLR265C(gene)|ensemblfungi:YLR265C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0035825"(homologous recombination)|go:"GO:0045002"(double-strand break repair via single-strand annealing)|go:"GO:0045027"(DNA end binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR015381(XLF/Cernunnos) psi-mi:"MI:0465"(dip) crc64:5BEDC72059E9996F crc64:5E09B5F851CF03B9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:IwFXSvAvdi5atkVDKt6aufYgKxw559292 rogid:K7Q6t345H+Vo/mrcMIVSHonlQ7o559292 rigid:ZgHdni2tsOM8WzLmBUAFW1uD9RQ false - maltose binding protein tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P12954 uniprotkb:Q06148 intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W intact:EBI-34047|uniprotkb:Q0P6Z6|uniprotkb:Q0P6Z7|uniprotkb:Q0P707|uniprotkb:D6VYR3|ensemblfungi:YLR265C psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name) psi-mi:nej1_yeast(display_long)|uniprotkb:NEJ1(gene name)|psi-mi:NEJ1(display_short)|uniprotkb:LIF2(gene name synonym)|uniprotkb:YLR265C(locus name) psi-mi:"MI:0096"(pull down) Carter et al. (2009) pubmed:19571008|doi:10.1073/pnas.0903869106|imex:IM-14764 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15792149|imex:IM-14764-2|dip:DIP-103976E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954 refseq:NP_013367.1|sgd:S000004255|mint:Q06148|dip:DIP-4776N|ensemblfungi:YLR265C(gene)|ensemblfungi:YLR265C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0035825"(homologous recombination)|go:"GO:0045002"(double-strand break repair via single-strand annealing)|go:"GO:0045027"(DNA end binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR015381(XLF/Cernunnos) psi-mi:"MI:0465"(dip) crc64:AE8061B114C32120 crc64:5E09B5F851CF03B9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292 rogid:K7Q6t345H+Vo/mrcMIVSHonlQ7o559292 rigid:zV4gvK+r3IEz6dM9TqpQ2+8PXR0 false sufficient binding region:810-1174 maltose binding protein tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P12954 uniprotkb:Q06148 intact:EBI-18110|uniprotkb:D6VW92|ensemblfungi:YJL092W intact:EBI-34047|uniprotkb:Q0P6Z6|uniprotkb:Q0P6Z7|uniprotkb:Q0P707|uniprotkb:D6VYR3|ensemblfungi:YLR265C psi-mi:srs2_yeast(display_long)|uniprotkb:SRS2(gene name)|psi-mi:SRS2(display_short)|uniprotkb:HPR5(gene name synonym)|uniprotkb:RADH(gene name synonym)|uniprotkb:YJL092W(locus name)|uniprotkb:J0913(orf name) psi-mi:nej1_yeast(display_long)|uniprotkb:NEJ1(gene name)|psi-mi:NEJ1(display_short)|uniprotkb:LIF2(gene name synonym)|uniprotkb:YLR265C(locus name) psi-mi:"MI:0018"(two hybrid) Carter et al. (2009) pubmed:19571008|doi:10.1073/pnas.0903869106|imex:IM-14764 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15792206|imex:IM-14764-5|dip:DIP-103976E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012443.1|sgd:S000003628|ensemblfungi:YJL092W(gene)|ensemblfungi:YJL092W_mRNA(transcript)|go:"GO:0000725"(recombinational repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0042262"(DNA protection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990986"(DNA recombinase disassembly)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR013986(DNA helicase, DEXX box type)|interpro:IPR014016(Helicase, superfamily 1, UvrD-related)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|rcsb pdb:3V62|go:"GO:0045910"(negative regulation of DNA recombination)|dip:DIP-415N|mint:P12954 refseq:NP_013367.1|sgd:S000004255|mint:Q06148|dip:DIP-4776N|ensemblfungi:YLR265C(gene)|ensemblfungi:YLR265C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032807"(DNA ligase IV complex)|go:"GO:0035825"(homologous recombination)|go:"GO:0045002"(double-strand break repair via single-strand annealing)|go:"GO:0045027"(DNA end binding)|go:"GO:0070419"(nonhomologous end joining complex)|interpro:IPR015381(XLF/Cernunnos) psi-mi:"MI:0465"(dip) crc64:AE8061B114C32120 crc64:5E09B5F851CF03B9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:GPTnvVDJ0ykp+hUzpxAC8L85UsE559292 rogid:K7Q6t345H+Vo/mrcMIVSHonlQ7o559292 rigid:zV4gvK+r3IEz6dM9TqpQ2+8PXR0 false binding-associated region:862-1174 mutation disrupting interaction:297-297,298-298|mutation disrupting interaction:297-297|mutation disrupting interaction:298-298 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)