#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q10589 uniprotkb:P59901 intact:EBI-2476339|ensembl:ENSP00000252593|intact:EBI-2839059|uniprotkb:A8K4Y4|uniprotkb:Q53G07 intact:EBI-2841591|uniprotkb:Q32MC4|ensembl:ENSP00000291759|ensembl:ENSP00000479979|ensembl:ENSP00000481073|ensembl:ENSP00000483846 psi-mi:bst2_human(display_long)|uniprotkb:BST2(gene name)|psi-mi:BST2(display_short)|uniprotkb:Tetherin(gene name synonym)|uniprotkb:HM1.24 antigen(gene name synonym) psi-mi:lira4_human(display_long)|uniprotkb:LILRA4(gene name)|psi-mi:LILRA4(display_short)|uniprotkb:ILT7(gene name synonym)|uniprotkb:CD85 antigen-like family member G(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 7(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Cao et al. (2009) pubmed:19564354|imex:IM-25724 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14032673|imex:IM-25724-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR024886|rcsb pdb:2LK9|rcsb pdb:2X7A|rcsb pdb:2XG7|rcsb pdb:3MQ7|rcsb pdb:3MQ9|rcsb pdb:3MQB|rcsb pdb:3MQC|rcsb pdb:3NWH|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0051607"(defense response to virus)|rcsb pdb:6DFF|go:"GO:0070062"(extracellular exosome)|go:"GO:0070665"(positive regulation of leukocyte proliferation)|go:"GO:1901253"(negative regulation of intracellular transport of viral material)|reactome:R-HSA-6798695|reactome:R-HSA-909733|ensembl:ENSG00000130303(gene)|ensembl:ENST00000252593(transcript)|go:"GO:0002737"(negative regulation of plasmacytoid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|refseq:NP_004326.1|dip:DIP-53216N refseq:NP_036408.4|ensembl:ENSG00000239961(gene)|ensembl:ENSG00000274185(gene)|ensembl:ENSG00000276798(gene)|ensembl:ENSG00000277092(gene)|ensembl:ENST00000291759(transcript)|ensembl:ENST00000613813(transcript)|ensembl:ENST00000616790(transcript)|ensembl:ENST00000619832(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032998"(Fc-epsilon receptor I complex)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0045087"(innate immune response)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016332(Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor)|interpro:IPR036179|reactome:R-HSA-198933 - - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/16 2017/04/20 rogid:vunnCOscGahFdaeN03pDo/8xW7I9606 rogid:RHvKRqjFRkYPFDZ1aAteqVqJaH09606 rigid:QPbyw3kvJJ6OPCuzI3ZzP/3+IEU false sufficient binding region:49..49-161..161|glutathione s tranferase tag:?-? fc-igg tag:?-?|sufficient binding region:24..24-446..446 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q10589 uniprotkb:P59901 intact:EBI-2476339|ensembl:ENSP00000252593|intact:EBI-2839059|uniprotkb:A8K4Y4|uniprotkb:Q53G07 intact:EBI-2841591|uniprotkb:Q32MC4|ensembl:ENSP00000291759|ensembl:ENSP00000479979|ensembl:ENSP00000481073|ensembl:ENSP00000483846 psi-mi:bst2_human(display_long)|uniprotkb:BST2(gene name)|psi-mi:BST2(display_short)|uniprotkb:Tetherin(gene name synonym)|uniprotkb:HM1.24 antigen(gene name synonym) psi-mi:lira4_human(display_long)|uniprotkb:LILRA4(gene name)|psi-mi:LILRA4(display_short)|uniprotkb:ILT7(gene name synonym)|uniprotkb:CD85 antigen-like family member G(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 7(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cao et al. (2009) pubmed:19564354|imex:IM-25724 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14032826|imex:IM-25724-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR024886|rcsb pdb:2LK9|rcsb pdb:2X7A|rcsb pdb:2XG7|rcsb pdb:3MQ7|rcsb pdb:3MQ9|rcsb pdb:3MQB|rcsb pdb:3MQC|rcsb pdb:3NWH|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0051607"(defense response to virus)|rcsb pdb:6DFF|go:"GO:0070062"(extracellular exosome)|go:"GO:0070665"(positive regulation of leukocyte proliferation)|go:"GO:1901253"(negative regulation of intracellular transport of viral material)|reactome:R-HSA-6798695|reactome:R-HSA-909733|ensembl:ENSG00000130303(gene)|ensembl:ENST00000252593(transcript)|go:"GO:0002737"(negative regulation of plasmacytoid dendritic cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|refseq:NP_004326.1|dip:DIP-53216N refseq:NP_036408.4|ensembl:ENSG00000239961(gene)|ensembl:ENSG00000274185(gene)|ensembl:ENSG00000276798(gene)|ensembl:ENSG00000277092(gene)|ensembl:ENST00000291759(transcript)|ensembl:ENST00000613813(transcript)|ensembl:ENST00000616790(transcript)|ensembl:ENST00000619832(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032998"(Fc-epsilon receptor I complex)|go:"GO:0034156"(negative regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0045087"(innate immune response)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016332(Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor)|interpro:IPR036179|reactome:R-HSA-198933 - - - figure legend:3C|antagonist:Monoclonal antibody 26F8 - BST2 target.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.0x10^-6(molar) 2017/03/16 2017/04/20 rogid:vunnCOscGahFdaeN03pDo/8xW7I9606 rogid:RHvKRqjFRkYPFDZ1aAteqVqJaH09606 rigid:QPbyw3kvJJ6OPCuzI3ZzP/3+IEU false sufficient binding region:49..49-161..161|glutathione s tranferase tag:?-? fc-igg tag:?-?|sufficient binding region:24..24-446..446 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)