#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92851	uniprotkb:O14730	intact:EBI-495095|uniprotkb:Q8WYQ8|uniprotkb:Q99845|uniprotkb:Q9Y2U6|uniprotkb:Q9Y2U7|uniprotkb:Q6KF62|uniprotkb:Q6KF63|uniprotkb:Q8IUP5|uniprotkb:Q68HC0|ensembl:ENSP00000272879	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:caspa_human(display_long)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737824|imex:IM-25636-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116756.2|refseq:NP_116758.1|refseq:NP_116759.2|refseq:NP_001193453.1|refseq:NP_001193471.1|refseq:NP_001221.2|refseq:NP_001293012.1|ensembl:ENSG00000003400(gene)|ensembl:ENST00000272879(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035701|mint:Q92851|reactome:R-HSA-6803207|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-933543	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/11	2017/01/11	rogid:3m6JTo82z7pldV6eFKO1BjrWwP09606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:/wAXZ8Aat3HYWwXQvt8g3g4ecxo	false	sufficient binding region:1-219..219	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q92851-7	uniprotkb:O14730	intact:EBI-12737837|ensembl:ENSP00000363781	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:q92851-7(display_long)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:10-G(isoform synonym)|uniprotkb:10g(isoform synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737843|imex:IM-25636-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-495095(isoform-parent)|ensembl:ENSG00000003400(gene)|ensembl:ENST00000374650(transcript)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/11	2017/01/11	rogid:wxzvOlNkwW033Cq5enVi28OQ1Mo9606	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rigid:tWNI1VqEpjE9+GzIPMA0sWFd2cU	false	his tag:n-n	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14730	uniprotkb:Q92851	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-495095|uniprotkb:Q8WYQ8|uniprotkb:Q99845|uniprotkb:Q9Y2U6|uniprotkb:Q9Y2U7|uniprotkb:Q6KF62|uniprotkb:Q6KF63|uniprotkb:Q8IUP5|uniprotkb:Q68HC0|ensembl:ENSP00000272879	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:caspa_human(display_long)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737866|imex:IM-25636-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	refseq:NP_116756.2|refseq:NP_116758.1|refseq:NP_116759.2|refseq:NP_001193453.1|refseq:NP_001193471.1|refseq:NP_001221.2|refseq:NP_001293012.1|ensembl:ENSG00000003400(gene)|ensembl:ENST00000272879(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035701|mint:Q92851|reactome:R-HSA-6803207|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-933543	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/01/11	2017/01/11	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:3m6JTo82z7pldV6eFKO1BjrWwP09606	rigid:/wAXZ8Aat3HYWwXQvt8g3g4ecxo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14730	uniprotkb:Q92851-7	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-12737837|ensembl:ENSP00000363781	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:q92851-7(display_long)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:10-G(isoform synonym)|uniprotkb:10g(isoform synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737877|imex:IM-25636-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	intact:EBI-495095(isoform-parent)|ensembl:ENSG00000003400(gene)|ensembl:ENST00000374650(transcript)	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/01/11	2017/01/11	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:wxzvOlNkwW033Cq5enVi28OQ1Mo9606	rigid:tWNI1VqEpjE9+GzIPMA0sWFd2cU	false	flag tag:?-?|sufficient binding region:222-470(IPR000687)	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14730	uniprotkb:Q92851-7	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-12737837|ensembl:ENSP00000363781	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:q92851-7(display_long)|uniprotkb:Apoptotic protease Mch-4(gene name synonym)|uniprotkb:FAS-associated death domain protein interleukin-1B-converting enzyme 2(gene name synonym)|uniprotkb:ICE-like apoptotic protease 4(gene name synonym)|uniprotkb:10-G(isoform synonym)|uniprotkb:10g(isoform synonym)|uniprotkb:CASP10(gene name)|psi-mi:CASP10(display_short)|uniprotkb:MCH4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737890|imex:IM-25636-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	intact:EBI-495095(isoform-parent)|ensembl:ENSG00000003400(gene)|ensembl:ENST00000374650(transcript)	-	-	-	figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/01/11	2017/01/11	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:wxzvOlNkwW033Cq5enVi28OQ1Mo9606	rigid:tWNI1VqEpjE9+GzIPMA0sWFd2cU	false	flag tag:?-?	myc tag:?-?|sufficient binding region:113-247|sufficient binding region:1-112	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14730	-	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	-	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Shan et al. (2009)	pubmed:19557502|imex:IM-25636	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-12737917|imex:IM-25636-6	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/01/11	2017/02/06	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	-	-	false	mutation disrupting interaction rate:290-290|flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-