#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9N2Z7 uniprotkb:Q21633 intact:EBI-317369|uniprotkb:Q95XU3|uniprotkb:V6CJJ8|uniprotkb:V6CLY4|ensemblmetazoa:Y65B4BR.4a.1 intact:EBI-325980|ensemblmetazoa:R01H2.6.1 psi-mi:wwp1_caeel(display_long)|uniprotkb:wwp-1(gene name)|psi-mi:wwp-1(display_short)|uniprotkb:Y65B4BR.4(orf name) psi-mi:ubc18_caeel(display_long)|uniprotkb:ubc-18(gene name)|psi-mi:ubc-18(display_short)|uniprotkb:R01H2.6(orf name) psi-mi:"MI:0096"(pull down) Carrano et al. (2009) pubmed:19553937|doi:10.1038/nature08130|imex:IM-16347 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15790745|imex:IM-16347-1|dip:DIP-139738E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) wormbase:Y65B4BR.4b|wormbase:Y65B4BR.4c|wormbase:Y65B4BR.4d|refseq:NP_740775.1|wormbase:Y65B4BR.4a|ensemblmetazoa:WBGene00007009(gene)|ensemblmetazoa:Y65B4BR.4a.1(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-CEL-1253288|reactome:R-CEL-983168|reactome:R-CEL-9013406|reactome:R-CEL-9013420|refseq:NP_001293271.1|refseq:NP_001293272.1|refseq:NP_740776.1|dip:DIP-25758N|reactome:R-CEL-2672351|reactome:R-CEL-8948751|reactome:R-CEL-5610780|reactome:R-CEL-5632684 refseq:NP_498541.1|wormbase:R01H2.6|ensemblmetazoa:R01H2.6.1(transcript)|ensemblmetazoa:WBGene00006713(gene)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|dip:DIP-26820N|reactome:R-CEL-8866652|reactome:R-CEL-983168|reactome:R-CEL-1169408|reactome:R-CEL-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:PlZNO3kcb422riUzp2aLH7Xaz3E6239 rogid:O2i/uZnMHlCI75ehro4zW3IcreI6239 rigid:pt43hNZTntTgw+QvaDjTFdfvLV4 false glutathione s tranferase tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q21633 uniprotkb:P14792 intact:EBI-325980|ensemblmetazoa:R01H2.6.1 intact:EBI-314130|dip:DIP-31819N|uniprotkb:Q9U1P3 psi-mi:ubc18_caeel(display_long)|uniprotkb:ubc-18(gene name)|psi-mi:ubc-18(display_short)|uniprotkb:R01H2.6(orf name) psi-mi:ubiq_caeel(display_long)|uniprotkb:ubq-1(gene name)|psi-mi:ubq-1(display_short)|uniprotkb:ubia(gene name synonym)|uniprotkb:F25B5.4(orf name)|uniprotkb:ubq-2(gene name)|psi-mi:ubq-2(display_short)|uniprotkb:ubib(gene name synonym)|uniprotkb:ZK1010.1(orf name) psi-mi:"MI:0808"(comigration in sds page) Carrano et al. (2009) pubmed:19553937|doi:10.1038/nature08130|imex:IM-16347 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15790769|imex:IM-16347-2|dip:DIP-187491E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_498541.1|wormbase:R01H2.6|ensemblmetazoa:R01H2.6.1(transcript)|ensemblmetazoa:WBGene00006713(gene)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|dip:DIP-26820N|reactome:R-CEL-8866652|reactome:R-CEL-983168|reactome:R-CEL-1169408|reactome:R-CEL-936440 go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0040007"(growth)|go:"GO:0002119"(nematode larval development)|go:"GO:0000003"(reproduction)|wormbase:WBGene00006727|wormbase:WBGene00006728|ensembl:ZK1010.1|interpro:IPR000626(Ubiquitin)|ensembl:F25B5.4|go:"GO:0005515"(protein binding)|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|refseq:NP_499695.1|refseq:NP_741157.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/15 rogid:O2i/uZnMHlCI75ehro4zW3IcreI6239 rogid:8xmsXBLusQw4LO/6iIfq1hGEP8A6239 rigid:WjUirWptj0v7EXfqRSs3cdhP1YU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)