#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18850	uniprotkb:Q53ET0	intact:EBI-852157|uniprotkb:O15139|uniprotkb:Q5VW62|uniprotkb:Q6IPB5|uniprotkb:Q9UEC9|ensembl:ENSP00000356919|ensembl:ENSP00000505025|ensembl:ENSP00000505998	intact:EBI-1181987|uniprotkb:Q7Z3X7|uniprotkb:Q6UUV8|uniprotkb:Q8N332|ensembl:ENSP00000357622	psi-mi:atf6a_human(display_long)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)|uniprotkb:ATF6(gene name)|psi-mi:ATF6(display_short)	psi-mi:crtc2_human(display_long)|uniprotkb:TORC2(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)|uniprotkb:CRTC2(gene name)|psi-mi:CRTC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790129|imex:IM-17849-2|dip:DIP-189292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031374.2|dip:DIP-29304N|ensembl:ENSG00000118217(gene)|ensembl:ENST00000367942(transcript)|ensembl:ENST00000681738(transcript)|ensembl:ENST00000681801(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029801|mint:P18850|reactome:R-HSA-380994|reactome:R-HSA-381033|reactome:R-HSA-381183|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)	refseq:NP_859066.1|ensembl:ENSP00000357622|ensembl:ENSG00000160741(gene)|ensembl:ENST00000368633(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|mint:Q53ET0|rcsb pdb:4HTM|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-29950N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mIU7Apng6rQ423SQnZTsceVSRus9606	rogid:p/QkUoueS1+KCLb0il8SMt8JwQM9606	rigid:lgxwQUwRF69qrY7/Y2WTIz1VNOQ	false	sufficient binding region:1-381|ha tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U182	uniprotkb:F6VAN0	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-6171558|ensembl:ENSMUSP00000027974|uniprotkb:B2RU98|uniprotkb:Q8BZ84	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:atf6a_mouse(display_long)|uniprotkb:Atf6(gene name)|psi-mi:Atf6(display_short)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790112|imex:IM-17849-1|dip:DIP-189291E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR029801|reactome:R-MMU-381033|ensembl:ENSMUSG00000026663(gene)|ensembl:ENSMUST00000027974(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|refseq:NP_001074773.1|dip:DIP-59768N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	caution:This sequence has been withdrawn from Uniprot.|crc64:C3ADCF7DF2CB3EC9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:nbb8fA8fCizE+gGUx52JpvXIFco10090	rigid:9DGVb9qisw+U0Zqjm1q0gg4Z+b0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U182	uniprotkb:P18850	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-852157|uniprotkb:O15139|uniprotkb:Q5VW62|uniprotkb:Q6IPB5|uniprotkb:Q9UEC9|ensembl:ENSP00000356919|ensembl:ENSP00000505025|ensembl:ENSP00000505998	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:atf6a_human(display_long)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)|uniprotkb:ATF6(gene name)|psi-mi:ATF6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790186|imex:IM-17849-5|dip:DIP-189293E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	refseq:NP_031374.2|dip:DIP-29304N|ensembl:ENSG00000118217(gene)|ensembl:ENST00000367942(transcript)|ensembl:ENST00000681738(transcript)|ensembl:ENST00000681801(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029801|mint:P18850|reactome:R-HSA-380994|reactome:R-HSA-381033|reactome:R-HSA-381183|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:mIU7Apng6rQ423SQnZTsceVSRus9606	rigid:Wo4VZYQ7bKpD6y3liFyRLuw0Swc	false	-	binding-associated region:1-381	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U182	uniprotkb:P18850	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-852157|uniprotkb:O15139|uniprotkb:Q5VW62|uniprotkb:Q6IPB5|uniprotkb:Q9UEC9|ensembl:ENSP00000356919|ensembl:ENSP00000505025|ensembl:ENSP00000505998	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:atf6a_human(display_long)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)|uniprotkb:ATF6(gene name)|psi-mi:ATF6(display_short)	psi-mi:"MI:0096"(pull down)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790205|imex:IM-17849-6|dip:DIP-189293E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	refseq:NP_031374.2|dip:DIP-29304N|ensembl:ENSG00000118217(gene)|ensembl:ENST00000367942(transcript)|ensembl:ENST00000681738(transcript)|ensembl:ENST00000681801(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029801|mint:P18850|reactome:R-HSA-380994|reactome:R-HSA-381033|reactome:R-HSA-381183|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:mIU7Apng6rQ423SQnZTsceVSRus9606	rigid:Wo4VZYQ7bKpD6y3liFyRLuw0Swc	false	sufficient binding region:1-120|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3U182	uniprotkb:F6VAN0	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-6171558|ensembl:ENSMUSP00000027974|uniprotkb:B2RU98|uniprotkb:Q8BZ84	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:atf6a_mouse(display_long)|uniprotkb:Atf6(gene name)|psi-mi:Atf6(display_short)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790169|imex:IM-17849-4|dip:DIP-189291E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR029801|reactome:R-MMU-381033|ensembl:ENSMUSG00000026663(gene)|ensembl:ENSMUST00000027974(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|refseq:NP_001074773.1|dip:DIP-59768N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	caution:This sequence has been withdrawn from Uniprot.|crc64:C3ADCF7DF2CB3EC9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:nbb8fA8fCizE+gGUx52JpvXIFco10090	rigid:9DGVb9qisw+U0Zqjm1q0gg4Z+b0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18850	uniprotkb:Q53ET0	intact:EBI-852157|uniprotkb:O15139|uniprotkb:Q5VW62|uniprotkb:Q6IPB5|uniprotkb:Q9UEC9|ensembl:ENSP00000356919|ensembl:ENSP00000505025|ensembl:ENSP00000505998	intact:EBI-1181987|uniprotkb:Q7Z3X7|uniprotkb:Q6UUV8|uniprotkb:Q8N332|ensembl:ENSP00000357622	psi-mi:atf6a_human(display_long)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)|uniprotkb:ATF6(gene name)|psi-mi:ATF6(display_short)	psi-mi:crtc2_human(display_long)|uniprotkb:TORC2(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)|uniprotkb:CRTC2(gene name)|psi-mi:CRTC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790150|imex:IM-17849-3|dip:DIP-189292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031374.2|dip:DIP-29304N|ensembl:ENSG00000118217(gene)|ensembl:ENST00000367942(transcript)|ensembl:ENST00000681738(transcript)|ensembl:ENST00000681801(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029801|mint:P18850|reactome:R-HSA-380994|reactome:R-HSA-381033|reactome:R-HSA-381183|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)	refseq:NP_859066.1|ensembl:ENSP00000357622|ensembl:ENSG00000160741(gene)|ensembl:ENST00000368633(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|mint:Q53ET0|rcsb pdb:4HTM|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-29950N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mIU7Apng6rQ423SQnZTsceVSRus9606	rogid:p/QkUoueS1+KCLb0il8SMt8JwQM9606	rigid:lgxwQUwRF69qrY7/Y2WTIz1VNOQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P18850	uniprotkb:Q53ET0	intact:EBI-852157|uniprotkb:O15139|uniprotkb:Q5VW62|uniprotkb:Q6IPB5|uniprotkb:Q9UEC9|ensembl:ENSP00000356919|ensembl:ENSP00000505025|ensembl:ENSP00000505998	intact:EBI-1181987|uniprotkb:Q7Z3X7|uniprotkb:Q6UUV8|uniprotkb:Q8N332|ensembl:ENSP00000357622	psi-mi:atf6a_human(display_long)|uniprotkb:Activating transcription factor 6 alpha(gene name synonym)|uniprotkb:ATF6(gene name)|psi-mi:ATF6(display_short)	psi-mi:crtc2_human(display_long)|uniprotkb:TORC2(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)|uniprotkb:CRTC2(gene name)|psi-mi:CRTC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2009)	pubmed:19543265|doi:10.1038/nature08111|imex:IM-17849	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15790228|imex:IM-17849-7|dip:DIP-189292E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031374.2|dip:DIP-29304N|ensembl:ENSG00000118217(gene)|ensembl:ENST00000367942(transcript)|ensembl:ENST00000681738(transcript)|ensembl:ENST00000681801(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0036500"(ATF6-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1903893"(positive regulation of ATF6-mediated unfolded protein response)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029801|mint:P18850|reactome:R-HSA-380994|reactome:R-HSA-381033|reactome:R-HSA-381183|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)	refseq:NP_859066.1|ensembl:ENSP00000357622|ensembl:ENSG00000160741(gene)|ensembl:ENST00000368633(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|mint:Q53ET0|rcsb pdb:4HTM|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-29950N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:mIU7Apng6rQ423SQnZTsceVSRus9606	rogid:p/QkUoueS1+KCLb0il8SMt8JwQM9606	rigid:lgxwQUwRF69qrY7/Y2WTIz1VNOQ	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)