#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00899	uniprotkb:P48432	intact:EBI-6921536|ensembl:ENSMUSP00000021692	intact:EBI-2313612	psi-mi:tyy1_mouse(display_long)|uniprotkb:Yy1(gene name)|psi-mi:Yy1(display_short)|uniprotkb:Ucrbp(gene name synonym)|uniprotkb:Delta transcription factor(gene name synonym)|uniprotkb:NF-E1(gene name synonym)|uniprotkb:UCR-motif DNA-binding protein(gene name synonym)|uniprotkb:Yin and yang 1(gene name synonym)	psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789164|imex:IM-16349-3|dip:DIP-187498E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000021692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|ensembl:ENSMUSG00000021264(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006403"(RNA localization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010225"(response to UV-C)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0051276"(chromosome organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017114(Transcription factor yin and yang)|interpro:IPR036236|mint:Q00899|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-9018519|refseq:NP_033563.2|dip:DIP-59285N	refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:TVKas6Dv9iMdl/6BfK+3FUIZnzs10090	rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090	rigid:ZWxOJfaunee3VZWD9P6UdqkXYTc	false	sufficient binding region:170-200|sufficient binding region:313-414|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01860	uniprotkb:P49711	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-932887|uniprotkb:Q53XI7|uniprotkb:B5MC38|uniprotkb:Q59EL8|ensembl:ENSP00000264010|ensembl:ENSP00000493495|ensembl:ENSP00000494408|ensembl:ENSP00000494538|ensembl:ENSP00000495348	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:ctcf_human(display_long)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)|uniprotkb:CTCF(gene name)|psi-mi:CTCF(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789147|imex:IM-16349-2|dip:DIP-187496E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_006556.1|refseq:NP_001177951.1|refseq:XP_016878357.1|dip:DIP-35252N|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P49711|rcsb pdb:1X6H|rcsb pdb:2CT1|rcsb pdb:5K5H|rcsb pdb:5K5I|rcsb pdb:5K5J|rcsb pdb:5K5L|rcsb pdb:5KKQ|rcsb pdb:5T00|rcsb pdb:5T0U|rcsb pdb:5UND|rcsb pdb:5YEF|rcsb pdb:5YEG|rcsb pdb:5YEH|rcsb pdb:5YEL|rcsb pdb:6QNX|reactome:R-HSA-5617472|ensembl:ENSG00000102974(gene)|ensembl:ENST00000264010(transcript)|ensembl:ENST00000642819(transcript)|ensembl:ENST00000644753(transcript)|ensembl:ENST00000645699(transcript)|ensembl:ENST00000646076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:hy9n/DVCzpfSi0EGigAjOZUvnIU9606	rigid:bzUpN2MmGYS85yl6avIT8vqHRts	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49711	uniprotkb:P20263	intact:EBI-932887|uniprotkb:Q53XI7|uniprotkb:B5MC38|uniprotkb:Q59EL8|ensembl:ENSP00000264010|ensembl:ENSP00000493495|ensembl:ENSP00000494408|ensembl:ENSP00000494538|ensembl:ENSP00000495348	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:ctcf_human(display_long)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)|uniprotkb:CTCF(gene name)|psi-mi:CTCF(display_short)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789126|imex:IM-16349-1|dip:DIP-187494E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006556.1|refseq:NP_001177951.1|refseq:XP_016878357.1|dip:DIP-35252N|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P49711|rcsb pdb:1X6H|rcsb pdb:2CT1|rcsb pdb:5K5H|rcsb pdb:5K5I|rcsb pdb:5K5J|rcsb pdb:5K5L|rcsb pdb:5KKQ|rcsb pdb:5T00|rcsb pdb:5T0U|rcsb pdb:5UND|rcsb pdb:5YEF|rcsb pdb:5YEG|rcsb pdb:5YEH|rcsb pdb:5YEL|rcsb pdb:6QNX|reactome:R-HSA-5617472|ensembl:ENSG00000102974(gene)|ensembl:ENST00000264010(transcript)|ensembl:ENST00000642819(transcript)|ensembl:ENST00000644753(transcript)|ensembl:ENST00000645699(transcript)|ensembl:ENST00000646076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:hy9n/DVCzpfSi0EGigAjOZUvnIU9606	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	rigid:yYEXFcF0DKuJg5uTTQzYPlD1YSA	false	sufficient binding region:284-583|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00899	uniprotkb:P48432	intact:EBI-6921536|ensembl:ENSMUSP00000021692	intact:EBI-2313612	psi-mi:tyy1_mouse(display_long)|uniprotkb:Yy1(gene name)|psi-mi:Yy1(display_short)|uniprotkb:Ucrbp(gene name synonym)|uniprotkb:Delta transcription factor(gene name synonym)|uniprotkb:NF-E1(gene name synonym)|uniprotkb:UCR-motif DNA-binding protein(gene name synonym)|uniprotkb:Yin and yang 1(gene name synonym)	psi-mi:sox2_mouse(display_long)|uniprotkb:Sox2(gene name)|psi-mi:Sox2(display_short)|uniprotkb:Sox-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789227|imex:IM-16349-6|dip:DIP-187498E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000021692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|ensembl:ENSMUSG00000021264(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006403"(RNA localization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010225"(response to UV-C)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0051276"(chromosome organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017114(Transcription factor yin and yang)|interpro:IPR036236|mint:Q00899|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-9018519|refseq:NP_033563.2|dip:DIP-59285N	refseq:NP_035573.3|mint:P48432|dip:DIP-54522N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030539"(male genitalia development)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035198"(miRNA binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046148"(pigment biosynthetic process)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048839"(inner ear development)|go:"GO:0048852"(diencephalon morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050973"(detection of mechanical stimulus involved in equilibrioception)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0070848"(response to growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|rcsb pdb:1GT0|rcsb pdb:6HT5|reactome:R-MMU-3769402|go:"GO:0035019"(somatic stem cell population maintenance)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:TVKas6Dv9iMdl/6BfK+3FUIZnzs10090	rogid:oO2sjv3/Iaj91kqGJ1L07+hhxVA10090	rigid:ZWxOJfaunee3VZWD9P6UdqkXYTc	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P20263	uniprotkb:Q61164	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	intact:EBI-932785|ensembl:ENSMUSP00000005841	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:ctcf_mouse(display_long)|uniprotkb:Ctcf(gene name)|psi-mi:Ctcf(display_short)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789204|imex:IM-16349-5|dip:DIP-187495E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	refseq:NP_851839.1|refseq:XP_006530711.1|dip:DIP-38020N|ensembl:ENSMUSG00000005698(gene)|ensembl:ENSMUST00000005841(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q61164|reactome:R-MMU-212436	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	rogid:r9BpKoiLzrCAiQttYFbIIkitePk10090	rigid:YGhA/QLEdVD3XIKsCkGOhu8tj1E	false	sufficient binding region:1-131|flag tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q01860	uniprotkb:P49711	intact:EBI-475687|uniprotkb:P31359|uniprotkb:Q15167|uniprotkb:Q15168|uniprotkb:Q16422|uniprotkb:A6NCS1|uniprotkb:A6NLL8|uniprotkb:Q5STF3|uniprotkb:Q5STF4|ensembl:ENSP00000259915|ensembl:ENSP00000373016|ensembl:ENSP00000388842|ensembl:ENSP00000391681|ensembl:ENSP00000392877|ensembl:ENSP00000400047|ensembl:ENSP00000405041|uniprotkb:D2IYK4	intact:EBI-932887|uniprotkb:Q53XI7|uniprotkb:B5MC38|uniprotkb:Q59EL8|ensembl:ENSP00000264010|ensembl:ENSP00000493495|ensembl:ENSP00000494408|ensembl:ENSP00000494538|ensembl:ENSP00000495348	psi-mi:po5f1_human(display_long)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:POU5F1(gene name)|psi-mi:POU5F1(display_short)|uniprotkb:OCT3(gene name synonym)|uniprotkb:OCT4(gene name synonym)|uniprotkb:OTF3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:ctcf_human(display_long)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCFL paralog(gene name synonym)|uniprotkb:11-zinc finger protein(gene name synonym)|uniprotkb:CTCF(gene name)|psi-mi:CTCF(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789187|imex:IM-16349-4|dip:DIP-187496E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272916.1|refseq:NP_002692.2|ensembl:ENSG00000204531(gene)|ensembl:ENSG00000206454(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0003723"(RNA binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|mint:Q01860|rcsb pdb:6T90|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-452723|ensembl:ENSG00000230336(gene)|ensembl:ENSG00000233911(gene)|ensembl:ENSG00000235068(gene)|ensembl:ENSG00000237582(gene)|ensembl:ENST00000259915(transcript)|ensembl:ENST00000383524(transcript)|ensembl:ENST00000429603(transcript)|ensembl:ENST00000433063(transcript)|ensembl:ENST00000434616(transcript)|ensembl:ENST00000437747(transcript)|ensembl:ENSG00000229094(gene)|ensembl:ENST00000454714(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|dip:DIP-33440N	refseq:NP_006556.1|refseq:NP_001177951.1|refseq:XP_016878357.1|dip:DIP-35252N|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031060"(regulation of histone methylation)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0040030"(obsolete regulation of molecular function, epigenetic)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071514"(genomic imprinting)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P49711|rcsb pdb:1X6H|rcsb pdb:2CT1|rcsb pdb:5K5H|rcsb pdb:5K5I|rcsb pdb:5K5J|rcsb pdb:5K5L|rcsb pdb:5KKQ|rcsb pdb:5T00|rcsb pdb:5T0U|rcsb pdb:5UND|rcsb pdb:5YEF|rcsb pdb:5YEG|rcsb pdb:5YEH|rcsb pdb:5YEL|rcsb pdb:6QNX|reactome:R-HSA-5617472|ensembl:ENSG00000102974(gene)|ensembl:ENST00000264010(transcript)|ensembl:ENST00000642819(transcript)|ensembl:ENST00000644753(transcript)|ensembl:ENST00000645699(transcript)|ensembl:ENST00000646076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:eMEp6g1n+kU2YnuRprn2B79q7OM9606	rogid:hy9n/DVCzpfSi0EGigAjOZUvnIU9606	rigid:bzUpN2MmGYS85yl6avIT8vqHRts	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00899	uniprotkb:P20263	intact:EBI-6921536|ensembl:ENSMUSP00000021692	intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271	psi-mi:tyy1_mouse(display_long)|uniprotkb:Yy1(gene name)|psi-mi:Yy1(display_short)|uniprotkb:Ucrbp(gene name synonym)|uniprotkb:Delta transcription factor(gene name synonym)|uniprotkb:NF-E1(gene name synonym)|uniprotkb:UCR-motif DNA-binding protein(gene name synonym)|uniprotkb:Yin and yang 1(gene name synonym)	psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Donohoe et al. (2009)	pubmed:19536159|doi:10.1038/nature08098|imex:IM-16349	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15789246|imex:IM-16349-7|dip:DIP-187497E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000021692(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|ensembl:ENSMUSG00000021264(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006403"(RNA localization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010225"(response to UV-C)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034696"(response to prostaglandin F)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048468"(cell development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0051276"(chromosome organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071707"(immunoglobulin heavy chain V-D-J recombination)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017114(Transcription factor yin and yang)|interpro:IPR036236|mint:Q00899|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-9018519|refseq:NP_033563.2|dip:DIP-59285N	refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:TVKas6Dv9iMdl/6BfK+3FUIZnzs10090	rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090	rigid:yR+f2OwF/Av4QTm7tgbcEM/yL8I	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)