#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25098	uniprotkb:Q13635	intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786116|imex:IM-14747-1|dip:DIP-103869E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:09xtip6sBQS20JEdqZCSunfydTY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14635	uniprotkb:Q13635	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786150|imex:IM-14747-3|dip:DIP-76446E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rigid:AhoH4nQUgoAHeCGH+NHe83JdeHk	false	ha tag:c-c	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13635	uniprotkb:P21146	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-1036401|ensembl:ENSBTAP00000050806	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786133|imex:IM-14747-2|dip:DIP-103868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rigid:8nB8Ln9P4W6x5wy5hWnyH7JZgAA	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13635	uniprotkb:P21146	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-1036401|ensembl:ENSBTAP00000050806	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786217|imex:IM-14747-6|dip:DIP-103868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rigid:8nB8Ln9P4W6x5wy5hWnyH7JZgAA	false	myc tag:c-c	flag tag:c-c|sufficient binding region:262-379	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13635	uniprotkb:P21146	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-1036401|ensembl:ENSBTAP00000050806	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786194|imex:IM-14747-5|dip:DIP-103868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rigid:8nB8Ln9P4W6x5wy5hWnyH7JZgAA	false	myc tag:c-c	flag tag:c-c|sufficient binding region:262-379	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13635	uniprotkb:P21146	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-1036401|ensembl:ENSBTAP00000050806	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786171|imex:IM-14747-4|dip:DIP-103868E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rigid:8nB8Ln9P4W6x5wy5hWnyH7JZgAA	false	glutathione s tranferase tag:n-n|sufficient binding region:1180-1447	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13635	uniprotkb:P14635	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786240|imex:IM-14747-7|dip:DIP-103870E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rigid:3PjBDjl3U108R/TJ8YXTPFt9rXQ	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13635	uniprotkb:P25098	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jiang et al. (2009)	pubmed:19502428|doi:10.1073/pnas.0812105106|imex:IM-14747	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15786240|imex:IM-14747-7|dip:DIP-103870E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606	rigid:3PjBDjl3U108R/TJ8YXTPFt9rXQ	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)