#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9VEZ5 uniprotkb:Q9VEZ5 intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344 intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344 psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name) psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name) psi-mi:"MI:0424"(protein kinase assay) Ertürk-Hasdemir et al. (2009) pubmed:19497884|doi:10.1073/pnas.0812022106|imex:IM-22448 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15786009|imex:IM-22448-1|dip:DIP-196166E - - psi-mi:"MI:0898"(putative self) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227 rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227 rigid:630d+/3/u9lHZm8QzPnR1zFud24 false mutation disrupting interaction rate:70-70 mutation disrupting interaction rate:70-70 - 0 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q9VEZ5 uniprotkb:Q94527-1 intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344 intact:EBI-15786027|ensemblmetazoa:FBpp0088375|ensemblmetazoa:FBpp0088971|ensemblmetazoa:FBpp0088973 psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name) psi-mi:q94527-1(display_long)|uniprotkb:C(isoform synonym)|uniprotkb:p110(isoform synonym)|uniprotkb:Rel-p110(gene name synonym)|uniprotkb:Relish protein(gene name synonym)|uniprotkb:CG11992(orf name)|uniprotkb:A(isoform synonym)|uniprotkb:B(isoform synonym)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short) psi-mi:"MI:0424"(protein kinase assay) Ertürk-Hasdemir et al. (2009) pubmed:19497884|doi:10.1073/pnas.0812022106|imex:IM-22448 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15786040|imex:IM-22448-2|dip:DIP-196165E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N intact:EBI-869024(isoform-parent)|ensemblmetazoa:FBgn0014018(gene)|ensemblmetazoa:FBtr0089338(transcript)|ensemblmetazoa:FBtr0089339(transcript)|ensemblmetazoa:FBtr0089340(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227 rogid:QSjX/buJS65odmpaKMzPkTgHW/Y7227 rigid:eVDVWjSriY0SO9bc5zqQ6gUoZXg false mutation disrupting interaction rate:70-70 O-phospho-L-serine:529-529,528-528 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VEZ5 uniprotkb:Q94527-1 intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344 intact:EBI-15786027|ensemblmetazoa:FBpp0088375|ensemblmetazoa:FBpp0088971|ensemblmetazoa:FBpp0088973 psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name) psi-mi:q94527-1(display_long)|uniprotkb:C(isoform synonym)|uniprotkb:p110(isoform synonym)|uniprotkb:Rel-p110(gene name synonym)|uniprotkb:Relish protein(gene name synonym)|uniprotkb:CG11992(orf name)|uniprotkb:A(isoform synonym)|uniprotkb:B(isoform synonym)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short) psi-mi:"MI:0424"(protein kinase assay) Ertürk-Hasdemir et al. (2009) pubmed:19497884|doi:10.1073/pnas.0812022106|imex:IM-22448 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15786062|imex:IM-22448-3|dip:DIP-196165E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N intact:EBI-869024(isoform-parent)|ensemblmetazoa:FBgn0014018(gene)|ensemblmetazoa:FBtr0089338(transcript)|ensemblmetazoa:FBtr0089339(transcript)|ensemblmetazoa:FBtr0089340(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227 rogid:QSjX/buJS65odmpaKMzPkTgHW/Y7227 rigid:eVDVWjSriY0SO9bc5zqQ6gUoZXg false - O-phospho-L-serine:529-529,528-528|mutation decreasing interaction rate:529-529,528-528 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)