#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42260 uniprotkb:P42260 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Kumar et al. (2009) pubmed:19465914|doi:10.1038/nsmb.1613|imex:IM-14278 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15782350|imex:IM-14278-1|dip:DIP-57284E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N psi-mi:"MI:0465"(dip) comment:mint comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rigid:So8UKXxUuPpETp9qBPgv5qghiso false binding-associated region:32-420 binding-associated region:32-420 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42260 uniprotkb:P42260 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Kumar et al. (2009) pubmed:19465914|doi:10.1038/nsmb.1613|imex:IM-14278 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15782386|imex:IM-14278-3|dip:DIP-57284E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N psi-mi:"MI:0465"(dip) comment:mint comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rigid:So8UKXxUuPpETp9qBPgv5qghiso false binding-associated region:32-420 binding-associated region:32-420 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42260 uniprotkb:P42260 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Kumar et al. (2009) pubmed:19465914|doi:10.1038/nsmb.1613|imex:IM-14278 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15782368|imex:IM-14278-2|dip:DIP-57284E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N psi-mi:"MI:0465"(dip) comment:mint comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rigid:So8UKXxUuPpETp9qBPgv5qghiso false binding-associated region:32-420 binding-associated region:32-420 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42260 uniprotkb:P42260 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884 psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym) psi-mi:"MI:0067"(light scattering) Kumar et al. (2009) pubmed:19465914|doi:10.1038/nsmb.1613|imex:IM-14278 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15782404|imex:IM-14278-4|dip:DIP-57284E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N psi-mi:"MI:0465"(dip) comment:mint comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116 rigid:So8UKXxUuPpETp9qBPgv5qghiso false binding-associated region:32-420 binding-associated region:32-420 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)