#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9JHG7 uniprotkb:Q99MK8 intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400 intact:EBI-771762|uniprotkb:Q99LL8|ensembl:ENSMUSP00000086114 psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym) psi-mi:arbk1_mouse(display_long)|uniprotkb:Grk2(gene name)|psi-mi:Grk2(display_short)|uniprotkb:Adrbk1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ito et al. (2009) pubmed:19429709|doi:10.1073/pnas.0900064106|imex:IM-14729 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15779690|imex:IM-14729-1|dip:DIP-103826E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N refseq:NP_001277747.1|dip:DIP-32413N|ensembl:ENSMUSG00000024858(gene)|ensembl:ENSMUST00000088737(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0010661"(positive regulation of muscle cell apoptotic process)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0030424"(axon)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0031850"(delta-type opioid receptor binding)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1904058"(positive regulation of sensory perception of pain)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:Q99MK8|reactome:R-MMU-111933|reactome:R-MMU-416476|reactome:R-MMU-418555|reactome:R-MMU-5635838|reactome:R-MMU-8856825 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090 rogid:boMMNI7l5ABURK9gD6uoeiJy7z810090 rigid:WdduONU+JCjoDFdigCjf+z3pCTY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)