#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H2X0 uniprotkb:P13497 intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name) psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:"MI:0435"(protease assay) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779577|imex:IM-14728-1|dip:DIP-103824E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0 refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rigid:Wteyy4B6JUkos8ovvvRqzqTwVX8 false - sufficient binding region:1-743 - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P13497 uniprotkb:P13497 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779612|imex:IM-14728-3|dip:DIP-103825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rigid:K7VhXL4oporwurDxYSpEeQjqris false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13497 uniprotkb:P13497 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:"MI:0067"(light scattering) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779628|imex:IM-14728-4|dip:DIP-103825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rigid:K7VhXL4oporwurDxYSpEeQjqris false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13497-2 uniprotkb:Q9H2X0 intact:EBI-12509497|ensembl:ENSP00000306121|ensembl:ENSP00000428332 intact:EBI-947551|intact:EBI-1752274|uniprotkb:O95254|uniprotkb:Q2M1I8|uniprotkb:Q6UW83|uniprotkb:Q9H2D3|uniprotkb:Q9H2W8|uniprotkb:Q9H2W9|uniprotkb:Q9P0Z2|uniprotkb:Q9P0Z3|uniprotkb:Q9P0Z4|uniprotkb:Q9P0Z5|intact:EBI-1957537|ensembl:ENSP00000204604 psi-mi:p13497-2(display_long)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:Procollagen C-proteinase(gene name synonym) psi-mi:chrd_human(display_long)|uniprotkb:CHRD(gene name)|psi-mi:CHRD(display_short)|uniprotkb:UNQ217/PRO243(orf name) psi-mi:"MI:0435"(protease assay) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0194"(cleavage reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779644|imex:IM-14728-5|dip:DIP-103824E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168487(gene)|ensembl:ENST00000306349(transcript)|ensembl:ENST00000520970(transcript)|intact:EBI-489827(isoform-parent) refseq:NP_003732.2|refseq:NP_001291401.1|refseq:NP_001291402.1|refseq:NP_001291403.1|dip:DIP-48857N|ensembl:ENSG00000090539(gene)|ensembl:ENST00000204604(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005615"(extracellular space)|go:"GO:0019955"(cytokine binding)|go:"GO:0021919"(BMP signaling pathway involved in spinal cord dorsal/ventral patterning)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0033504"(floor plate development)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)|mint:Q9H2X0 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:lObdtVRHmod2GwGddF7d51zcmVE9606 rogid:Y/WHkB30K8nEcaaL2wyikwWH1kg9606 rigid:A4I2Dl2yGKRZrKTX0YDG0jabyKY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13497 uniprotkb:P13497 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779596|imex:IM-14728-2|dip:DIP-103825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rigid:K7VhXL4oporwurDxYSpEeQjqris false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13497 uniprotkb:P13497 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714 psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Berry et al. (2009) pubmed:19429706|doi:10.1073/pnas.0812178106|imex:IM-14728 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15779661|imex:IM-14728-6|dip:DIP-103825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rogid:IS39foZyMR0650AjBaf1gA8YD/k9606 rigid:K7VhXL4oporwurDxYSpEeQjqris false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)