#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BZM5 uniprotkb:P16757 intact:EBI-3919993|ensembl:ENSP00000356320|uniprotkb:Q5VUN4 intact:EBI-16417596|uniprotkb:Q7M6R7 psi-mi:ulbp2_human(display_long)|uniprotkb:ULBP2(gene name)|psi-mi:ULBP2(display_short)|uniprotkb:NKG2D ligand 2(gene name synonym)|uniprotkb:N2DL2(gene name synonym)|uniprotkb:RAET1H(gene name synonym)|uniprotkb:ALCAN-alpha(gene name synonym)|uniprotkb:Retinoic acid early transcript 1H(gene name synonym)|uniprotkb:UNQ463/PRO791(orf name) psi-mi:ul16p_hcmva(display_long)|uniprotkb:UL16(gene name)|psi-mi:UL16(display_short) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10360(hcmva)|taxid:10360("Human cytomegalovirus (strain AD169) (HHV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417583|imex:IM-26183-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000131015(gene)|ensembl:ENST00000367351(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125|refseq:NP_079493.1 interpro:IPR038671|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039671"(evasion by virus of host natural killer cell activity)|rcsb pdb:2WY3|interpro:IPR035123 - - - figure legend:3A-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:zuq4AAgsMCKpAdAWhIZxEcpcv4Q9606 rogid:aVtCNUHQHasmBk/aKN75oMNXKvg10360 rigid:ztZw8yC2dUnpI0rVciggv7T8hEk false flag tag:n-n fc-igg tag:c-c|sufficient binding region:1-184 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P26718 uniprotkb:Q6H3X3 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-458334|uniprotkb:Q6H3X2|ensembl:ENSP00000356329 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp5_human(display_long)|uniprotkb:Retinoic acid early transcript 1G protein(gene name synonym)|uniprotkb:ULBP5(gene name synonym)|uniprotkb:RAET1G(gene name)|psi-mi:RAET1G(display_short) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417713|imex:IM-26183-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N refseq:NP_001001788.2|ensembl:ENSG00000203722(gene)|ensembl:ENST00000367360(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125 - - - figure legend:3C|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:/3UcRKlG0ZVjmxNQsbDapHK/D989606 rigid:0IwCfrKV4mU0sWfGW3/HlwMxNqo false biotin tag:?-?|sufficient binding region:73..73-216..216 sufficient binding region:1-191|fc-igg tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P26718 uniprotkb:Q9BZM5 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-3919993|ensembl:ENSP00000356320|uniprotkb:Q5VUN4 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp2_human(display_long)|uniprotkb:ULBP2(gene name)|psi-mi:ULBP2(display_short)|uniprotkb:NKG2D ligand 2(gene name synonym)|uniprotkb:N2DL2(gene name synonym)|uniprotkb:RAET1H(gene name synonym)|uniprotkb:ALCAN-alpha(gene name synonym)|uniprotkb:Retinoic acid early transcript 1H(gene name synonym)|uniprotkb:UNQ463/PRO791(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417733|imex:IM-26183-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N ensembl:ENSG00000131015(gene)|ensembl:ENST00000367351(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125|refseq:NP_079493.1 - - - figure legend:3C-2|comment:strong binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:zuq4AAgsMCKpAdAWhIZxEcpcv4Q9606 rigid:qiGQVKKlU1M60tQrOfSLZODu5ng false biotin tag:?-?|sufficient binding region:73..73-216..216 sufficient binding region:26-217|fc-igg tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P26718 uniprotkb:Q9BZM5 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-3919993|ensembl:ENSP00000356320|uniprotkb:Q5VUN4 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp2_human(display_long)|uniprotkb:ULBP2(gene name)|psi-mi:ULBP2(display_short)|uniprotkb:NKG2D ligand 2(gene name synonym)|uniprotkb:N2DL2(gene name synonym)|uniprotkb:RAET1H(gene name synonym)|uniprotkb:ALCAN-alpha(gene name synonym)|uniprotkb:Retinoic acid early transcript 1H(gene name synonym)|uniprotkb:UNQ463/PRO791(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417747|imex:IM-26183-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N ensembl:ENSG00000131015(gene)|ensembl:ENST00000367351(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125|refseq:NP_079493.1 - - - figure legend:3D|comment:strong binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:zuq4AAgsMCKpAdAWhIZxEcpcv4Q9606 rigid:qiGQVKKlU1M60tQrOfSLZODu5ng false - sufficient binding region:26-217|fc-igg tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P26718 uniprotkb:Q6H3X3 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-458334|uniprotkb:Q6H3X2|ensembl:ENSP00000356329 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp5_human(display_long)|uniprotkb:Retinoic acid early transcript 1G protein(gene name synonym)|uniprotkb:ULBP5(gene name synonym)|uniprotkb:RAET1G(gene name)|psi-mi:RAET1G(display_short) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417761|imex:IM-26183-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N refseq:NP_001001788.2|ensembl:ENSG00000203722(gene)|ensembl:ENST00000367360(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125 - - - figure legend:3D|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:/3UcRKlG0ZVjmxNQsbDapHK/D989606 rigid:0IwCfrKV4mU0sWfGW3/HlwMxNqo false - fc-igg tag:c-c|sufficient binding region:1-191 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9BZM5 uniprotkb:P26718 intact:EBI-3919993|ensembl:ENSP00000356320|uniprotkb:Q5VUN4 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 psi-mi:ulbp2_human(display_long)|uniprotkb:ULBP2(gene name)|psi-mi:ULBP2(display_short)|uniprotkb:NKG2D ligand 2(gene name synonym)|uniprotkb:N2DL2(gene name synonym)|uniprotkb:RAET1H(gene name synonym)|uniprotkb:ALCAN-alpha(gene name synonym)|uniprotkb:Retinoic acid early transcript 1H(gene name synonym)|uniprotkb:UNQ463/PRO791(orf name) psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417662|imex:IM-26183-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000131015(gene)|ensembl:ENST00000367351(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125|refseq:NP_079493.1 reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N - - - figure legend:3A, Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:zuq4AAgsMCKpAdAWhIZxEcpcv4Q9606 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rigid:qiGQVKKlU1M60tQrOfSLZODu5ng false mutation decreasing interaction strength:141-141|flag tag:n-n biotin tag:c-c|red fluorescent protein tag:c-c|sufficient binding region:93..93-215..215 - 4 psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P26718 uniprotkb:Q6H3X3 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-458334|uniprotkb:Q6H3X2|ensembl:ENSP00000356329 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp5_human(display_long)|uniprotkb:Retinoic acid early transcript 1G protein(gene name synonym)|uniprotkb:ULBP5(gene name synonym)|uniprotkb:RAET1G(gene name)|psi-mi:RAET1G(display_short) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417677|imex:IM-26183-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N refseq:NP_001001788.2|ensembl:ENSG00000203722(gene)|ensembl:ENST00000367360(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125 - - - figure legend:3B|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:/3UcRKlG0ZVjmxNQsbDapHK/D989606 rigid:0IwCfrKV4mU0sWfGW3/HlwMxNqo false biotin tag:c-c|red fluorescent protein tag:c-c|sufficient binding region:93..93-215..215 sufficient binding region:1-191|fc-igg tag:c-c 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P26718 uniprotkb:Q9BZM5 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 intact:EBI-3919993|ensembl:ENSP00000356320|uniprotkb:Q5VUN4 psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:ulbp2_human(display_long)|uniprotkb:ULBP2(gene name)|psi-mi:ULBP2(display_short)|uniprotkb:NKG2D ligand 2(gene name synonym)|uniprotkb:N2DL2(gene name synonym)|uniprotkb:RAET1H(gene name synonym)|uniprotkb:ALCAN-alpha(gene name synonym)|uniprotkb:Retinoic acid early transcript 1H(gene name synonym)|uniprotkb:UNQ463/PRO791(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417696|imex:IM-26183-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N ensembl:ENSG00000131015(gene)|ensembl:ENST00000367351(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125|refseq:NP_079493.1 - - - figure legend:3B-2|comment:strong binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rogid:zuq4AAgsMCKpAdAWhIZxEcpcv4Q9606 rigid:qiGQVKKlU1M60tQrOfSLZODu5ng false biotin tag:c-c|red fluorescent protein tag:c-c|sufficient binding region:93..93-215..215 sufficient binding region:26-217(IPR011162)|fc-igg tag:c-c 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q6H3X3 uniprotkb:P26718 intact:EBI-458334|uniprotkb:Q6H3X2|ensembl:ENSP00000356329 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 psi-mi:ulbp5_human(display_long)|uniprotkb:Retinoic acid early transcript 1G protein(gene name synonym)|uniprotkb:ULBP5(gene name synonym)|uniprotkb:RAET1G(gene name)|psi-mi:RAET1G(display_short) psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) Wittenbrink et al. (2009) pubmed:19424970|imex:IM-26183 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-16417843|imex:IM-26183-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001788.2|ensembl:ENSG00000203722(gene)|ensembl:ENST00000367360(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR037055|reactome:R-HSA-163125 reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N - - - figure legend:Supp fig 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/07/06 2017/09/19 rogid:/3UcRKlG0ZVjmxNQsbDapHK/D989606 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 rigid:0IwCfrKV4mU0sWfGW3/HlwMxNqo false mutation:141-141|flag tag:n-n biotin tag:c-c|red fluorescent protein tag:c-c|sufficient binding region:93..93-215..215 - 4 psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)