#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51577	uniprotkb:P51577	intact:EBI-9511617|ensembl:ENSRNOP00000001752	intact:EBI-9511617|ensembl:ENSRNOP00000001752	psi-mi:p2rx4_rat(display_long)|uniprotkb:P2rx4(gene name)|psi-mi:P2rx4(display_short)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)	psi-mi:p2rx4_rat(display_long)|uniprotkb:P2rx4(gene name)|psi-mi:P2rx4(display_short)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Shinozaki et al. (2009)	pubmed:19419241|doi:10.1371/journal.pbio.1000103|imex:IM-14157	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15779297|imex:IM-14157-1|dip:DIP-102838E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:62073|refseq:NP_113782.1|dip:DIP-48411N|ensembl:ENSRNOG00000001300(gene)|ensembl:ENSRNOT00000001752(transcript)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002931"(response to ischemia)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033198"(response to ATP)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0099604"(ligand-gated calcium channel activity)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003047(P2X4 purinoceptor)|interpro:IPR027309|rcsb pdb:2BP5|rcsb pdb:2RUP|reactome:R-RNO-139853|reactome:R-RNO-418346	rgd:62073|refseq:NP_113782.1|dip:DIP-48411N|ensembl:ENSRNOG00000001300(gene)|ensembl:ENSRNOT00000001752(transcript)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002931"(response to ischemia)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033198"(response to ATP)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0099604"(ligand-gated calcium channel activity)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003047(P2X4 purinoceptor)|interpro:IPR027309|rcsb pdb:2BP5|rcsb pdb:2RUP|reactome:R-RNO-139853|reactome:R-RNO-418346	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:ogsHtvyxaAmmFUflijf6YfBuW7U10116	rogid:ogsHtvyxaAmmFUflijf6YfBuW7U10116	rigid:CDGpKyFt7PPg48t62wSk4LoL7s4	false	-	-	-	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:P51577	uniprotkb:P51577	intact:EBI-9511617|ensembl:ENSRNOP00000001752	intact:EBI-9511617|ensembl:ENSRNOP00000001752	psi-mi:p2rx4_rat(display_long)|uniprotkb:P2rx4(gene name)|psi-mi:P2rx4(display_short)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)	psi-mi:p2rx4_rat(display_long)|uniprotkb:P2rx4(gene name)|psi-mi:P2rx4(display_short)|uniprotkb:ATP receptor(gene name synonym)|uniprotkb:Purinergic receptor(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Shinozaki et al. (2009)	pubmed:19419241|doi:10.1371/journal.pbio.1000103|imex:IM-14157	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15779313|imex:IM-14157-2|dip:DIP-102838E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:62073|refseq:NP_113782.1|dip:DIP-48411N|ensembl:ENSRNOG00000001300(gene)|ensembl:ENSRNOT00000001752(transcript)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002931"(response to ischemia)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033198"(response to ATP)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0099604"(ligand-gated calcium channel activity)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003047(P2X4 purinoceptor)|interpro:IPR027309|rcsb pdb:2BP5|rcsb pdb:2RUP|reactome:R-RNO-139853|reactome:R-RNO-418346	rgd:62073|refseq:NP_113782.1|dip:DIP-48411N|ensembl:ENSRNOG00000001300(gene)|ensembl:ENSRNOT00000001752(transcript)|go:"GO:0001614"(purinergic nucleotide receptor activity)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002931"(response to ischemia)|go:"GO:0004931"(extracellularly ATP-gated cation channel activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030054"(cell junction)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033198"(response to ATP)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035590"(purinergic nucleotide receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098662"(inorganic cation transmembrane transport)|go:"GO:0099604"(ligand-gated calcium channel activity)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001429(P2X purinoreceptor)|interpro:IPR003047(P2X4 purinoceptor)|interpro:IPR027309|rcsb pdb:2BP5|rcsb pdb:2RUP|reactome:R-RNO-139853|reactome:R-RNO-418346	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:ogsHtvyxaAmmFUflijf6YfBuW7U10116	rogid:ogsHtvyxaAmmFUflijf6YfBuW7U10116	rigid:CDGpKyFt7PPg48t62wSk4LoL7s4	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)