#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21784	uniprotkb:P15919	intact:EBI-7602123|intact:MINT-8384500|ensembl:ENSMUSP00000038204|ensembl:ENSMUSP00000106858	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	psi-mi:rag2_mouse(display_long)|uniprotkb:Rag2(gene name)|psi-mi:Rag2(display_short)|uniprotkb:Rag-2(gene name synonym)	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:"MI:0096"(pull down)	Yin et al. (2009)	pubmed:19396172|doi:10.1038/nsmb.1593|imex:IM-14273	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771939|imex:IM-14273-1|dip:DIP-103074E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017172095.1|refseq:NP_033046.1|ensembl:ENSMUSG00000032864(gene)|ensembl:ENSMUST00000044031(transcript)|ensembl:ENSMUST00000111227(transcript)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0002358"(B cell homeostatic proliferation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006325"(chromatin organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035064"(methylated histone binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097519"(DNA recombinase complex)|interpro:IPR004321(V-D-J recombination activating protein 2)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR025162|rcsb pdb:2JWO|rcsb pdb:2V83|rcsb pdb:2V85|rcsb pdb:2V86|rcsb pdb:2V87|rcsb pdb:2V88|rcsb pdb:2V89|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|rcsb pdb:6OEO|dip:DIP-46179N	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:YNZD3oEaJR86dm4pNKPl4Qu+N5g10090	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rigid:tOH+AkFVl2yfoXHkNkQ7VfrIR38	false	binding-associated region:1-383|glutathione s tranferase tag:n-n	binding-associated region:384-1008|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15919	uniprotkb:P15919	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Yin et al. (2009)	pubmed:19396172|doi:10.1038/nsmb.1593|imex:IM-14273	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771964|imex:IM-14273-2|dip:DIP-103073E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rigid:kvb9MR19GOoFbHMIPJysagmPPl0	false	binding-associated region:389-464	binding-associated region:389-464	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15919	uniprotkb:P15919	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:"MI:0067"(light scattering)	Yin et al. (2009)	pubmed:19396172|doi:10.1038/nsmb.1593|imex:IM-14273	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771982|imex:IM-14273-3|dip:DIP-103073E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rigid:kvb9MR19GOoFbHMIPJysagmPPl0	false	binding-associated region:389-464	binding-associated region:389-464	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15919	uniprotkb:P15919	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	intact:EBI-7602168|uniprotkb:A2AVN8|intact:MINT-4131682|ensembl:ENSMUSP00000077584	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:rag1_mouse(display_long)|uniprotkb:Rag1(gene name)|psi-mi:Rag1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Yin et al. (2009)	pubmed:19396172|doi:10.1038/nsmb.1593|imex:IM-14273	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15772002|imex:IM-14273-4|dip:DIP-103073E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	refseq:NP_033045.2|refseq:XP_006499075.1|ensembl:ENSMUSG00000061311(gene)|ensembl:ENSMUST00000078494(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|mint:P15919|rcsb pdb:1RMD|rcsb pdb:3GNA|rcsb pdb:3GNB|rcsb pdb:4WWX|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|rcsb pdb:6OEP|rcsb pdb:6OEQ|rcsb pdb:6OER|rcsb pdb:6OES|rcsb pdb:6OET|rcsb pdb:6V0V|rcsb pdb:6XNX|rcsb pdb:6XNY|rcsb pdb:6XNZ|dip:DIP-48518N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	comment:mint|comment:homomint|function:"During lymphocyte development, the genes encoding immunoglobulins and T-cell receptors are assembled from variable (V), diversity (D), and joining (J) gene segments. This combinatorial process, known as V(D)J recombination, allows the generation of an enormous range of binding specificities from a limited amount of genetic information. The RAG1/RAG2 complex initiates this process by binding to the conserved recombination signal sequences (RSS) and introducing a double-strand break between the RSS and the adjacent coding segment. These breaks are generated in two steps, nicking of one strand (hydrolysis), followed by hairpin formation (transesterification). RAG1/2 has also been shown to function as a transposase in vitro, and to possess RSS-independent endonuclease activity (end processing) and hairpin opening. RAG1 alone can bind to RSS but stable, efficient binding requires RAG2. All known catalytic activities require the presence of both proteins"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rogid:lNU1wsHGASek68/oGDqzf0aue6A10090	rigid:kvb9MR19GOoFbHMIPJysagmPPl0	false	binding-associated region:389-464	binding-associated region:389-464	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)