#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2S7-3	uniprotkb:Q9WU38	intact:EBI-15771036|ensembl:ENSMUSP00000108620	intact:EBI-11424593|ensembl:ENSMUSP00000033161	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:scnnb_mouse(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771048|imex:IM-17938-1|dip:DIP-189434E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	refseq:NP_001258952.1|refseq:NP_035455.1|ensembl:ENSMUSG00000030873(gene)|ensembl:ENSMUST00000033161(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|dip:DIP-40891N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphoserine at position 40.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rogid:/65P0VhRYbJSvqxGYO/D3OYZflA10090	rigid:+UAGejkVsCal+nokz2fQ8uBM0zA	false	-	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WVC6	uniprotkb:Q99N57	intact:EBI-15591730|ensembl:ENSMUSP00000020145|uniprotkb:Q3TJN4|uniprotkb:Q3UKD0|uniprotkb:Q3UKF2|uniprotkb:Q3V1V1|uniprotkb:Q6NS85	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:sgk1_mouse(display_long)|uniprotkb:Sgk1(gene name)|psi-mi:Sgk1(display_short)|uniprotkb:Sgk(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771088|imex:IM-17938-3|dip:DIP-189432E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019970(gene)|ensembl:ENSMUST00000020145(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-2672351|reactome:R-MMU-6804757|reactome:R-MMU-9031628|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007616"(long-term memory)|go:"GO:0008542"(visual learning)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043402"(glucocorticoid mediated signaling pathway)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0005739"(mitochondrion)|refseq:NP_001155317.2|refseq:NP_001155319.1|refseq:NP_001155320.1|refseq:NP_001155321.1|refseq:NP_001155322.1|refseq:NP_035491.1|dip:DIP-48845N	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:6qlouObpA5/EKnd/AAJXSfR5jZ010090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:BdkvLool1kzQkVsJqW3heb576JU	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CFI0	uniprotkb:Q9WU38	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-11424593|ensembl:ENSMUSP00000033161	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:scnnb_mouse(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771067|imex:IM-17938-2|dip:DIP-189428E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	refseq:NP_001258952.1|refseq:NP_035455.1|ensembl:ENSMUSG00000030873(gene)|ensembl:ENSMUST00000033161(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|dip:DIP-40891N	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:/65P0VhRYbJSvqxGYO/D3OYZflA10090	rigid:7pO7plQJOmN32OltehoQ6s4mt0o	false	flag tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99N57	uniprotkb:Q9Z2S7	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	intact:EBI-15771128|ensembl:ENSMUSP00000062589|uniprotkb:B1AVF3|uniprotkb:C6EX03|uniprotkb:Q3UNI6|uniprotkb:Q8K160|uniprotkb:Q9EQN0|uniprotkb:Q9EQN1|uniprotkb:Q9EQN2	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:t22d3_mouse(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771169|imex:IM-17938-5|dip:DIP-189431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000055738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|interpro:IPR000580(TSC-22 / Dip / Bun)|reactome:R-MMU-2672351|refseq:NP_001070832.1|refseq:NP_034416.3|refseq:XP_006528562.1|refseq:XP_006528563.1|refseq:XP_006528564.1|refseq:XP_006528566.1|refseq:XP_006528567.1|refseq:XP_006528568.1|dip:DIP-48844N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rogid:dL2mVYP+cp0QGH7QZuxZ5vWhWJI10090	rigid:vdSP9BqN62wr+uP9lKUjD8h6LWA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFI0	uniprotkb:Q99N57	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771186|imex:IM-17938-6|dip:DIP-189430E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:Ekw+NR4h8EVB8+kd5L6eVwszhlc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:Q61180	dip:DIP-24261N	intact:EBI-11424565|uniprotkb:Q9WU37	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:scnna_mouse(display_long)|uniprotkb:Scnn1a(gene name)|psi-mi:Scnn1a(display_short)|uniprotkb:Alpha-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771109|imex:IM-17938-4|dip:DIP-189437E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_035454.2|reactome:R-MMU-2672351|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|dip:DIP-40889N	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:L6P8OMpJM5gcu70YCbkYTIKRuhM10090	rigid:8lCDC4nXcrbSYuGiVBaG1+eLOeo	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99N57	uniprotkb:Q9WU38	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	intact:EBI-11424593|ensembl:ENSMUSP00000033161	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:scnnb_mouse(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771203|imex:IM-17938-7|dip:DIP-189429E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	refseq:NP_001258952.1|refseq:NP_035455.1|ensembl:ENSMUSG00000030873(gene)|ensembl:ENSMUST00000033161(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|dip:DIP-40891N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rogid:/65P0VhRYbJSvqxGYO/D3OYZflA10090	rigid:DWbtTgQC+4TjxbHRzmoNpL8FaOI	false	flag tag:n-n	v5 tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WVC6	uniprotkb:Q99N57	intact:EBI-15591730|ensembl:ENSMUSP00000020145|uniprotkb:Q3TJN4|uniprotkb:Q3UKD0|uniprotkb:Q3UKF2|uniprotkb:Q3V1V1|uniprotkb:Q6NS85	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:sgk1_mouse(display_long)|uniprotkb:Sgk1(gene name)|psi-mi:Sgk1(display_short)|uniprotkb:Sgk(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771224|imex:IM-17938-8|dip:DIP-189432E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019970(gene)|ensembl:ENSMUST00000020145(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-2672351|reactome:R-MMU-6804757|reactome:R-MMU-9031628|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007616"(long-term memory)|go:"GO:0008542"(visual learning)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043402"(glucocorticoid mediated signaling pathway)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0005739"(mitochondrion)|refseq:NP_001155317.2|refseq:NP_001155319.1|refseq:NP_001155320.1|refseq:NP_001155321.1|refseq:NP_001155322.1|refseq:NP_035491.1|dip:DIP-48845N	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:6qlouObpA5/EKnd/AAJXSfR5jZ010090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:BdkvLool1kzQkVsJqW3heb576JU	false	ha tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFI0	uniprotkb:Q9Z2S7	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-15771128|ensembl:ENSMUSP00000062589|uniprotkb:B1AVF3|uniprotkb:C6EX03|uniprotkb:Q3UNI6|uniprotkb:Q8K160|uniprotkb:Q9EQN0|uniprotkb:Q9EQN1|uniprotkb:Q9EQN2	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:t22d3_mouse(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771245|imex:IM-17938-9|dip:DIP-189436E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000055738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|interpro:IPR000580(TSC-22 / Dip / Bun)|reactome:R-MMU-2672351|refseq:NP_001070832.1|refseq:NP_034416.3|refseq:XP_006528562.1|refseq:XP_006528563.1|refseq:XP_006528564.1|refseq:XP_006528566.1|refseq:XP_006528567.1|refseq:XP_006528568.1|dip:DIP-48844N	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:dL2mVYP+cp0QGH7QZuxZ5vWhWJI10090	rigid:4GohC0dbwyQZHrbXW5z5DPZvIiQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFI0	uniprotkb:Q9WVC6	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-15591730|ensembl:ENSMUSP00000020145|uniprotkb:Q3TJN4|uniprotkb:Q3UKD0|uniprotkb:Q3UKF2|uniprotkb:Q3V1V1|uniprotkb:Q6NS85	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:sgk1_mouse(display_long)|uniprotkb:Sgk1(gene name)|psi-mi:Sgk1(display_short)|uniprotkb:Sgk(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771262|imex:IM-17938-10|dip:DIP-189435E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	ensembl:ENSMUSG00000019970(gene)|ensembl:ENSMUST00000020145(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-2672351|reactome:R-MMU-6804757|reactome:R-MMU-9031628|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007616"(long-term memory)|go:"GO:0008542"(visual learning)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043402"(glucocorticoid mediated signaling pathway)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0005739"(mitochondrion)|refseq:NP_001155317.2|refseq:NP_001155319.1|refseq:NP_001155320.1|refseq:NP_001155321.1|refseq:NP_001155322.1|refseq:NP_035491.1|dip:DIP-48845N	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:6qlouObpA5/EKnd/AAJXSfR5jZ010090	rigid:r3aUPMdeUqDAo35SlXxEoIPj8/s	false	flag tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFI0	uniprotkb:Q99N57	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771283|imex:IM-17938-11|dip:DIP-189430E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:Ekw+NR4h8EVB8+kd5L6eVwszhlc	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61180	uniprotkb:Q9Z2S7	intact:EBI-11424565|uniprotkb:Q9WU37	intact:EBI-15771128|ensembl:ENSMUSP00000062589|uniprotkb:B1AVF3|uniprotkb:C6EX03|uniprotkb:Q3UNI6|uniprotkb:Q8K160|uniprotkb:Q9EQN0|uniprotkb:Q9EQN1|uniprotkb:Q9EQN2	psi-mi:scnna_mouse(display_long)|uniprotkb:Scnn1a(gene name)|psi-mi:Scnn1a(display_short)|uniprotkb:Alpha-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)	psi-mi:t22d3_mouse(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771302|imex:IM-17938-12|dip:DIP-189438E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035454.2|reactome:R-MMU-2672351|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|dip:DIP-40889N	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000055738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|interpro:IPR000580(TSC-22 / Dip / Bun)|reactome:R-MMU-2672351|refseq:NP_001070832.1|refseq:NP_034416.3|refseq:XP_006528562.1|refseq:XP_006528563.1|refseq:XP_006528564.1|refseq:XP_006528566.1|refseq:XP_006528567.1|refseq:XP_006528568.1|dip:DIP-48844N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:L6P8OMpJM5gcu70YCbkYTIKRuhM10090	rogid:dL2mVYP+cp0QGH7QZuxZ5vWhWJI10090	rigid:gFYDRM48EwQqdnhUlOvWODElWlw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2S7-3	uniprotkb:Q9WVC6	intact:EBI-15771036|ensembl:ENSMUSP00000108620	intact:EBI-15591730|ensembl:ENSMUSP00000020145|uniprotkb:Q3TJN4|uniprotkb:Q3UKD0|uniprotkb:Q3UKF2|uniprotkb:Q3V1V1|uniprotkb:Q6NS85	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:sgk1_mouse(display_long)|uniprotkb:Sgk1(gene name)|psi-mi:Sgk1(display_short)|uniprotkb:Sgk(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771319|imex:IM-17938-13|dip:DIP-189433E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	ensembl:ENSMUSG00000019970(gene)|ensembl:ENSMUST00000020145(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-2672351|reactome:R-MMU-6804757|reactome:R-MMU-9031628|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007616"(long-term memory)|go:"GO:0008542"(visual learning)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043402"(glucocorticoid mediated signaling pathway)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0005739"(mitochondrion)|refseq:NP_001155317.2|refseq:NP_001155319.1|refseq:NP_001155320.1|refseq:NP_001155321.1|refseq:NP_001155322.1|refseq:NP_035491.1|dip:DIP-48845N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphoserine at position 40.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rogid:6qlouObpA5/EKnd/AAJXSfR5jZ010090	rigid:jO98iQR/yjZnZgQ2sj3/j1/gGac	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFI0	uniprotkb:Q9Z2S7-3	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-15771036|ensembl:ENSMUSP00000108620	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771338|imex:IM-17938-14|dip:DIP-189436E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	isoform-comment:Contains a phosphoserine at position 40.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rigid:8tapbdfTDsP1kXecagIKTImEkwg	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2S7-3	uniprotkb:Q9WVC6	intact:EBI-15771036|ensembl:ENSMUSP00000108620	intact:EBI-15591730|ensembl:ENSMUSP00000020145|uniprotkb:Q3TJN4|uniprotkb:Q3UKD0|uniprotkb:Q3UKF2|uniprotkb:Q3V1V1|uniprotkb:Q6NS85	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:sgk1_mouse(display_long)|uniprotkb:Sgk1(gene name)|psi-mi:Sgk1(display_short)|uniprotkb:Sgk(gene name synonym)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771412|imex:IM-17938-18|dip:DIP-189433E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	ensembl:ENSMUSG00000019970(gene)|ensembl:ENSMUST00000020145(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-2672351|reactome:R-MMU-6804757|reactome:R-MMU-9031628|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007616"(long-term memory)|go:"GO:0008542"(visual learning)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043402"(glucocorticoid mediated signaling pathway)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0005739"(mitochondrion)|refseq:NP_001155317.2|refseq:NP_001155319.1|refseq:NP_001155320.1|refseq:NP_001155321.1|refseq:NP_001155322.1|refseq:NP_035491.1|dip:DIP-48845N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphoserine at position 40.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rogid:6qlouObpA5/EKnd/AAJXSfR5jZ010090	rigid:jO98iQR/yjZnZgQ2sj3/j1/gGac	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2S7-3	uniprotkb:Q99N57	intact:EBI-15771036|ensembl:ENSMUSP00000108620	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771393|imex:IM-17938-17|dip:DIP-189431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphoserine at position 40.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:OzrkhKPqh9AwKVOmHMPfQkUXraU	false	-	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WU38	uniprotkb:Q9Z2S7	intact:EBI-11424593|ensembl:ENSMUSP00000033161	intact:EBI-15771128|ensembl:ENSMUSP00000062589|uniprotkb:B1AVF3|uniprotkb:C6EX03|uniprotkb:Q3UNI6|uniprotkb:Q8K160|uniprotkb:Q9EQN0|uniprotkb:Q9EQN1|uniprotkb:Q9EQN2	psi-mi:scnnb_mouse(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:t22d3_mouse(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771376|imex:IM-17938-16|dip:DIP-189434E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258952.1|refseq:NP_035455.1|ensembl:ENSMUSG00000030873(gene)|ensembl:ENSMUST00000033161(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|dip:DIP-40891N	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000055738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|interpro:IPR000580(TSC-22 / Dip / Bun)|reactome:R-MMU-2672351|refseq:NP_001070832.1|refseq:NP_034416.3|refseq:XP_006528562.1|refseq:XP_006528563.1|refseq:XP_006528564.1|refseq:XP_006528566.1|refseq:XP_006528567.1|refseq:XP_006528568.1|dip:DIP-48844N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:/65P0VhRYbJSvqxGYO/D3OYZflA10090	rogid:dL2mVYP+cp0QGH7QZuxZ5vWhWJI10090	rigid:MTR/V23Fz3EH6smVW6moqsjJdJE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2S7-3	uniprotkb:Q99N57	intact:EBI-15771036|ensembl:ENSMUSP00000108620	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771357|imex:IM-17938-15|dip:DIP-189431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphoserine at position 40.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rigid:OzrkhKPqh9AwKVOmHMPfQkUXraU	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFI0	uniprotkb:Q9Z2S7-3	intact:EBI-8046183|uniprotkb:Q8BS42|uniprotkb:Q8BRT9|intact:MINT-5097552|uniprotkb:Q99PK2	intact:EBI-15771036|ensembl:ENSMUSP00000108620	psi-mi:ned4l_mouse(display_long)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:Nedd4l(gene name)|psi-mi:Nedd4l(display_short)|uniprotkb:Kiaa0439(gene name synonym)|uniprotkb:Nedd4b(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:q9z2s7-3(display_long)|uniprotkb:Tsc22d3(gene name)|psi-mi:Tsc22d3(display_short)|uniprotkb:Dsip1(gene name synonym)|uniprotkb:Dsipi(gene name synonym)|uniprotkb:Gilz(gene name synonym)|uniprotkb:Glucocorticoid-induced leucine zipper protein(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper 3(gene name synonym)|uniprotkb:Tilz3c(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Soundararajan et al. (2009)	pubmed:19380724|doi:10.1073/pnas.0809892106|imex:IM-17938	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15771431|imex:IM-17938-19|dip:DIP-189436E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-48843N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0009651"(response to salt stress)|go:"GO:0010038"(response to metal ion)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:1WR3|rcsb pdb:1WR4|rcsb pdb:1WR7|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-MMU-2173795|reactome:R-MMU-2672351|reactome:R-MMU-983168	ensembl:ENSMUSG00000031431(gene)|ensembl:ENSMUST00000112996(transcript)|intact:EBI-15771128(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK	isoform-comment:Contains a phosphoserine at position 40.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:rne2aA4b/xoATCErEBuu9uK3Zxk10090	rogid:n/jOLYvhqwlsseCtd/YdJ1tgeAw10090	rigid:8tapbdfTDsP1kXecagIKTImEkwg	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)