#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q02817 uniprotkb:O95994 intact:EBI-2105803|uniprotkb:Q14878 intact:EBI-712648|ensembl:ENSP00000391490 psi-mi:muc2_human(display_long)|uniprotkb:MUC2(gene name)|psi-mi:MUC2(display_short)|uniprotkb:SMUC(gene name synonym)|uniprotkb:Intestinal mucin-2(gene name synonym) psi-mi:agr2_human(display_long)|uniprotkb:Secreted cement gland protein XAG-2 homolog(gene name synonym)|uniprotkb:HPC8(gene name synonym)|uniprotkb:AG2(gene name synonym)|uniprotkb:UNQ515/PRO1030(orf name)|uniprotkb:AGR2(gene name)|psi-mi:AGR2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Park et al. (2009) pubmed:19359471|doi:10.1073/pnas.0808722106|imex:IM-14711 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15768239|imex:IM-14711-1|dip:DIP-103781E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-913709|reactome:R-HSA-977068|reactome:R-HSA-5621480|dip:DIP-48824N|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070702"(inner mucus layer)|go:"GO:0070703"(outer mucus layer)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025155|interpro:IPR028580|interpro:IPR036084|rcsb pdb:6RBF|rcsb pdb:6TM6|rcsb pdb:7A5O go:"GO:0005615"(extracellular space)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060480"(lung goblet cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070254"(mucus secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|interpro:IPR036249|rcsb pdb:2LNS|rcsb pdb:2LNT|ensembl:ENSG00000106541(gene)|ensembl:ENST00000419304(transcript)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|refseq:NP_006399.1|refseq:XP_005249638.1|dip:DIP-48825N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:8pzwGZXJw7CRgFAaNIuZgcTDxms9606 rogid:E824a1MDXuGzk23ohjS7HAeEx5U9606 rigid:SwVBKi+YKKGfICLdYB6MAve3ovo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02817 uniprotkb:O95994 intact:EBI-2105803|uniprotkb:Q14878 intact:EBI-712648|ensembl:ENSP00000391490 psi-mi:muc2_human(display_long)|uniprotkb:MUC2(gene name)|psi-mi:MUC2(display_short)|uniprotkb:SMUC(gene name synonym)|uniprotkb:Intestinal mucin-2(gene name synonym) psi-mi:agr2_human(display_long)|uniprotkb:Secreted cement gland protein XAG-2 homolog(gene name synonym)|uniprotkb:HPC8(gene name synonym)|uniprotkb:AG2(gene name synonym)|uniprotkb:UNQ515/PRO1030(orf name)|uniprotkb:AGR2(gene name)|psi-mi:AGR2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Park et al. (2009) pubmed:19359471|doi:10.1073/pnas.0808722106|imex:IM-14711 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15768256|imex:IM-14711-2|dip:DIP-103781E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-5083625|reactome:R-HSA-5083632|reactome:R-HSA-5083636|reactome:R-HSA-913709|reactome:R-HSA-977068|reactome:R-HSA-5621480|dip:DIP-48824N|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031012"(extracellular matrix)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070702"(inner mucus layer)|go:"GO:0070703"(outer mucus layer)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR025155|interpro:IPR028580|interpro:IPR036084|rcsb pdb:6RBF|rcsb pdb:6TM6|rcsb pdb:7A5O go:"GO:0005615"(extracellular space)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060480"(lung goblet cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070254"(mucus secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|interpro:IPR036249|rcsb pdb:2LNS|rcsb pdb:2LNT|ensembl:ENSG00000106541(gene)|ensembl:ENST00000419304(transcript)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|refseq:NP_006399.1|refseq:XP_005249638.1|dip:DIP-48825N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:8pzwGZXJw7CRgFAaNIuZgcTDxms9606 rogid:E824a1MDXuGzk23ohjS7HAeEx5U9606 rigid:SwVBKi+YKKGfICLdYB6MAve3ovo false binding-associated region:1-1397|binding-associated region:4198-5179|myc tag:c-c mutation disrupting interaction:81-81|flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)