#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P26358 intact:EBI-4399559 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 dip:DIP-24261N psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15764132|imex:IM-14694-1|dip:DIP-103716E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) - no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/06 2017/08/15 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:qSc9Px5dX8iNqSO/ks0ZNmZr4Lk false - ha tag:0-0 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26358 uniprotkb:Q8WTS6 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0213"(methylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15764151|imex:IM-14694-2|dip:DIP-103717E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false binding-associated region:136-147 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26358 uniprotkb:Q8WTS6 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:"MI:0096"(pull down) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15764170|imex:IM-14694-3|dip:DIP-103717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false sufficient binding region:1-446|sufficient binding region:1081-1408|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26358 uniprotkb:Q8WTS6 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:"MI:0096"(pull down) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15764193|imex:IM-14694-4|dip:DIP-103717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false - sufficient binding region:1-240|glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WTS6 uniprotkb:P26358 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15764214|imex:IM-14694-5|dip:DIP-103717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-15764231 uniprotkb:Q8WTS6 dip:DIP-48782N intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 psi-mi:h3-10(display_short)|psi-mi:EBI-15764231(display_long) psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0213"(methylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15764234|imex:IM-14694-6|dip:DIP-103718E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:F+0wj4b94N+WG3/UnEjIpafsJQY-2 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rigid:8/eoXCozFuTESEAtLDO5iJAzugQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P26358 uniprotkb:Q8WTS6 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0213"(methylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15764251|imex:IM-14694-7|dip:DIP-103717E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false sufficient binding region:92-159 - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8WTS6 uniprotkb:P26358 intact:EBI-1268586|uniprotkb:Q4W5A9|uniprotkb:Q0VAH3|uniprotkb:Q9C0E6|uniprotkb:B5WWL3|ensembl:ENSP00000274031 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 psi-mi:setd7_human(display_long)|uniprotkb:SETD7(gene name)|psi-mi:SETD7(display_short)|uniprotkb:KIAA1717(gene name synonym)|uniprotkb:SET7(gene name synonym)|uniprotkb:KMT7(gene name synonym)|uniprotkb:SET9(gene name synonym)|uniprotkb:Histone H3-K4 methyltransferase SETD7(gene name synonym)|uniprotkb:SET domain-containing protein 7(gene name synonym)|uniprotkb:SET7/9(gene name synonym)|uniprotkb:Lysine N-methyltransferase 7(gene name synonym) psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Estève et al. (2009) pubmed:19282482|doi:10.1073/pnas.0810362106|imex:IM-14694 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15764270|imex:IM-14694-8|dip:DIP-103717E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_085151.1|dip:DIP-29045N|refseq:NP_001293128.1|ensembl:ENSG00000145391(gene)|ensembl:ENST00000274031(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|interpro:IPR001214(SET)|interpro:IPR003409(MORN motif)|interpro:IPR017155(Histone-lysine N-methyltransferase, SET)|interpro:IPR044436|mint:Q8WTS6|rcsb pdb:1H3I|rcsb pdb:1MT6|rcsb pdb:1MUF|rcsb pdb:1N6A|rcsb pdb:1N6C|rcsb pdb:1O9S|rcsb pdb:1XQH|rcsb pdb:2F69|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:3M53|rcsb pdb:3M54|rcsb pdb:3M55|rcsb pdb:3M56|rcsb pdb:3M57|rcsb pdb:3M58|rcsb pdb:3M59|rcsb pdb:3M5A|rcsb pdb:3OS5|rcsb pdb:3VUZ|rcsb pdb:3VV0|rcsb pdb:4E47|rcsb pdb:4J7F|rcsb pdb:4J7I|rcsb pdb:4J83|rcsb pdb:4J8O|rcsb pdb:4JDS|rcsb pdb:4JLG|rcsb pdb:5AYF|go:"GO:0018026"(peptidyl-lysine monomethylation)|rcsb pdb:5EG2|rcsb pdb:5YLT|reactome:R-HSA-3214841 ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:wqmjJBZrQZT1Uydm62Moi9oGNtQ9606 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rigid:eXnJlJffPDtwVyf0egrobmaiBNY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)