#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P46736 uniprotkb:Q96RL1-1 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-9640371|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:q96rl1-1(display_long)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RXRIP110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:RAP80(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Shao et al. (2009) pubmed:19202061|doi:10.1073/pnas.0807485106|imex:IM-14627 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15756183|imex:IM-14627-1|dip:DIP-103546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|intact:EBI-725300(isoform-parent) psi-mi:"MI:0465"(dip) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rigid:Yl4o2A7ZDW8PAv0IU6KRMTxcH2I false sufficient binding region:1-13|flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P46736 uniprotkb:P38398 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Shao et al. (2009) pubmed:19202061|doi:10.1073/pnas.0807485106|imex:IM-14627 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15756183|imex:IM-14627-1|dip:DIP-103546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N psi-mi:"MI:0465"(dip) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606 rigid:Yl4o2A7ZDW8PAv0IU6KRMTxcH2I false sufficient binding region:1-13|flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P16104 intact:EBI-4399559 intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024 dip:DIP-24261N psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Shao et al. (2009) pubmed:19202061|doi:10.1073/pnas.0807485106|imex:IM-14627 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15756205|imex:IM-14627-2|dip:DIP-66436E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) - no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/15 rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:g7oUEcaOpoeATDz9iuKkIokdjZA false flag tag:n-n ha tag:0-0 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96RL1-1 uniprotkb:P46736 intact:EBI-9640371|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 psi-mi:q96rl1-1(display_long)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RXRIP110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:RAP80(gene name synonym) psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Shao et al. (2009) pubmed:19202061|doi:10.1073/pnas.0807485106|imex:IM-14627 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15756226|imex:IM-14627-3|dip:DIP-103545E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|intact:EBI-725300(isoform-parent) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0465"(dip) - caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rigid:Hevw/rtSp7MCye7dtYzbam71+Jc false sufficient binding region:233-399|flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)