#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9JI33 uniprotkb:P70211-1 intact:EBI-15755373|ensembl:ENSMUSP00000020204|uniprotkb:E9QMT3 intact:EBI-15755366|ensembl:ENSMUSP00000110593 psi-mi:net4_mouse(display_long)|uniprotkb:Ntn4(gene name)|psi-mi:Ntn4(display_short)|uniprotkb:Beta-netrin(gene name synonym) psi-mi:p70211-1(display_long)|uniprotkb:Dcc(gene name)|psi-mi:Dcc(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym) psi-mi:"MI:0096"(pull down) Staquicini et al. (2009) pubmed:19193855|doi:10.1073/pnas.0813286106|imex:IM-22421 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15755400|imex:IM-22421-1|dip:DIP-196095E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020019(gene)|ensembl:ENSMUST00000020204(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043256"(laminin complex)|go:"GO:0060668"(regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR035811|rcsb pdb:4WNX|reactome:R-MMU-373752|refseq:NP_067295.2|dip:DIP-60741N intact:EBI-1798863(isoform-parent)|ensembl:ENSMUSG00000060534(gene)|ensembl:ENSMUST00000114943(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:8bDlJ9qTjIsGSrdRYHugc4LqOZk10090 rogid:EMyR8LhWLCvJIBIAEn9dULe8Xfo10090 rigid:4GdI0yKKTA/vxiJng1UsLXA5t+k false sufficient binding region:19-628 sufficient binding region:32-1097|fc-igg tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O08722 uniprotkb:Q9JI33 intact:EBI-4404185 intact:EBI-15755373|ensembl:ENSMUSP00000020204|uniprotkb:E9QMT3 psi-mi:unc5b_rat(display_long)|uniprotkb:Unc5b(gene name)|psi-mi:Unc5b(display_short)|uniprotkb:Unc5h2(gene name synonym)|uniprotkb:Protein unc-5 homolog 2(gene name synonym)|uniprotkb:Protein unc-5 homolog B(gene name synonym) psi-mi:net4_mouse(display_long)|uniprotkb:Ntn4(gene name)|psi-mi:Ntn4(display_short)|uniprotkb:Beta-netrin(gene name synonym) psi-mi:"MI:0096"(pull down) Staquicini et al. (2009) pubmed:19193855|doi:10.1073/pnas.0813286106|imex:IM-22421 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15755444|imex:IM-22421-3|dip:DIP-196097E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621756|refseq:NP_071543.1|dip:DIP-60743N|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000488(Death)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR000906(ZU5)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033772|interpro:IPR036179|interpro:IPR036383|interpro:IPR037936|interpro:IPR042156|rcsb pdb:3G5B|go:"GO:0045121"(membrane raft) ensembl:ENSMUSG00000020019(gene)|ensembl:ENSMUST00000020204(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043256"(laminin complex)|go:"GO:0060668"(regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR035811|rcsb pdb:4WNX|reactome:R-MMU-373752|refseq:NP_067295.2|dip:DIP-60741N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:eMLpHKP8+9+6y69jsrnTolsZdEI10116 rogid:8bDlJ9qTjIsGSrdRYHugc4LqOZk10090 rigid:tCb/3La21h26oXOHVOEqjeje+DY false sufficient binding region:27-373|fc-igg tag:c-c sufficient binding region:19-628 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O08721 uniprotkb:Q9JI33 intact:EBI-15755467 intact:EBI-15755373|ensembl:ENSMUSP00000020204|uniprotkb:E9QMT3 psi-mi:unc5a_rat(display_long)|uniprotkb:Unc5a(gene name)|psi-mi:Unc5a(display_short)|uniprotkb:Unc5h1(gene name synonym)|uniprotkb:Protein unc-5 homolog 1(gene name synonym)|uniprotkb:Protein unc-5 homolog A(gene name synonym) psi-mi:net4_mouse(display_long)|uniprotkb:Ntn4(gene name)|psi-mi:Ntn4(display_short)|uniprotkb:Beta-netrin(gene name synonym) psi-mi:"MI:0096"(pull down) Staquicini et al. (2009) pubmed:19193855|doi:10.1073/pnas.0813286106|imex:IM-22421 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15755498|imex:IM-22421-4|dip:DIP-196096E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0045121"(membrane raft)|interpro:IPR000488(Death)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR000906(ZU5)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011029(DEATH-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033772|interpro:IPR036179|interpro:IPR036383|interpro:IPR037936|interpro:IPR042155|reactome:R-RNO-373752|refseq:NP_071542.1|dip:DIP-60742N|rgd:621755 ensembl:ENSMUSG00000020019(gene)|ensembl:ENSMUST00000020204(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043256"(laminin complex)|go:"GO:0060668"(regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR035811|rcsb pdb:4WNX|reactome:R-MMU-373752|refseq:NP_067295.2|dip:DIP-60741N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:h4ItFf0FHtTxXGbQ/PyIy1TQq5E10116 rogid:8bDlJ9qTjIsGSrdRYHugc4LqOZk10090 rigid:qgK+RcJzl6EuE6R+n7yRbmCKNjA false sufficient binding region:26-358|fc-igg tag:c-c sufficient binding region:19-628 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P02468 uniprotkb:Q9JI33 intact:EBI-7059830|intact:MINT-1031545 intact:EBI-15755373|ensembl:ENSMUSP00000020204|uniprotkb:E9QMT3 psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:net4_mouse(display_long)|uniprotkb:Ntn4(gene name)|psi-mi:Ntn4(display_short)|uniprotkb:Beta-netrin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Staquicini et al. (2009) pubmed:19193855|doi:10.1073/pnas.0813286106|imex:IM-22421 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15755425|imex:IM-22421-2|dip:DIP-196098E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N ensembl:ENSMUSG00000020019(gene)|ensembl:ENSMUST00000020204(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043256"(laminin complex)|go:"GO:0060668"(regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR035811|rcsb pdb:4WNX|reactome:R-MMU-373752|refseq:NP_067295.2|dip:DIP-60741N psi-mi:"MI:0465"(dip) comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 rogid:8bDlJ9qTjIsGSrdRYHugc4LqOZk10090 rigid:BCqDTGemCmNTAMlfrplsl9z93yw false - sufficient binding region:19-628 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P02468 uniprotkb:Q9JI33 intact:EBI-7059830|intact:MINT-1031545 intact:EBI-15755373|ensembl:ENSMUSP00000020204|uniprotkb:E9QMT3 psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:net4_mouse(display_long)|uniprotkb:Ntn4(gene name)|psi-mi:Ntn4(display_short)|uniprotkb:Beta-netrin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Staquicini et al. (2009) pubmed:19193855|doi:10.1073/pnas.0813286106|imex:IM-22421 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15755521|imex:IM-22421-5|dip:DIP-196098E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N ensembl:ENSMUSG00000020019(gene)|ensembl:ENSMUST00000020204(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043256"(laminin complex)|go:"GO:0060668"(regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR035811|rcsb pdb:4WNX|reactome:R-MMU-373752|refseq:NP_067295.2|dip:DIP-60741N psi-mi:"MI:0465"(dip) comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 rogid:8bDlJ9qTjIsGSrdRYHugc4LqOZk10090 rigid:BCqDTGemCmNTAMlfrplsl9z93yw false - sufficient binding region:19-628 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)