#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41695	uniprotkb:P41695	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751053|imex:IM-11793-1|dip:DIP-102566E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	psi-mi:"MI:0465"(dip)	crc64:6D76FC980775D3F9	crc64:6D76FC980775D3F9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rigid:0ZBB3w04Nj9fb18Q1xudihgYzEw	false	binding-associated region:29-230	binding-associated region:29-230	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P41695	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0016"(circular dichroism)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751071|imex:IM-11793-2|dip:DIP-102566E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	psi-mi:"MI:0465"(dip)	crc64:6D76FC980775D3F9	crc64:6D76FC980775D3F9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rigid:0ZBB3w04Nj9fb18Q1xudihgYzEw	false	binding-associated region:29-230	binding-associated region:29-230	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P41695	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751126|imex:IM-11793-5|dip:DIP-102566E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	psi-mi:"MI:0465"(dip)	crc64:6D76FC980775D3F9	crc64:6D76FC980775D3F9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rigid:0ZBB3w04Nj9fb18Q1xudihgYzEw	false	binding-associated region:29-230	binding-associated region:29-230	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P41695	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0826"(x ray scattering)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751108|imex:IM-11793-4|dip:DIP-102566E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	psi-mi:"MI:0465"(dip)	crc64:6D76FC980775D3F9	crc64:6D76FC980775D3F9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rigid:0ZBB3w04Nj9fb18Q1xudihgYzEw	false	binding-associated region:29-230	binding-associated region:29-230	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41695	uniprotkb:P41695	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	intact:EBI-3816|uniprotkb:D6VUX1|ensemblfungi:YGR188C	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:bub1_yeast(display_long)|uniprotkb:YGR188C(locus name)|uniprotkb:G7542(orf name)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751090|imex:IM-11793-3|dip:DIP-102566E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	sgd:S000003420|refseq:NP_011704.3|dip:DIP-2236N|mint:P41695|ensemblfungi:YGR188C(gene)|ensemblfungi:YGR188C_mRNA(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016236"(macroautophagy)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034508"(centromere complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012572(Mad3-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2I3S|rcsb pdb:3ESL|rcsb pdb:4BL0|reactome:R-SCE-141430	psi-mi:"MI:0465"(dip)	crc64:6D76FC980775D3F9	crc64:6D76FC980775D3F9	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rogid:O4X/wXB2iXRdSVxIGA9nG1Sj5dI559292	rigid:0ZBB3w04Nj9fb18Q1xudihgYzEw	false	binding-associated region:29-230	binding-associated region:29-230	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NG31-2	uniprotkb:O43683	intact:EBI-10973816|ensembl:ENSP00000382576	intact:EBI-748936|uniprotkb:O43430|uniprotkb:O43643|uniprotkb:O60626|uniprotkb:Q53QE4|intact:EBI-10974242|uniprotkb:E9PC26|uniprotkb:F5GXI5|intact:EBI-28974347|ensembl:ENSP00000302530	psi-mi:q8ng31-2(display_long)|uniprotkb:KNL1(gene name)|psi-mi:KNL1(display_short)|uniprotkb:ALL1-fused gene from chromosome 15q14 protein(gene name synonym)|uniprotkb:Bub-linking kinetochore protein(gene name synonym)|uniprotkb:CASC5(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 5 protein(gene name synonym)|uniprotkb:Cancer/testis antigen 29(gene name synonym)|uniprotkb:KIAA1570(gene name synonym)|uniprotkb:Kinetochore-null protein 1(gene name synonym)|uniprotkb:Protein CASC5(gene name synonym)|uniprotkb:Protein D40/AF15q14(gene name synonym)	psi-mi:bub1_human(display_long)|uniprotkb:BUB1A(gene name synonym)|uniprotkb:BUB1(gene name)|psi-mi:BUB1(display_short)|uniprotkb:BUB1L(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bolanos-Garcia et al. (2009)	pubmed:19141287|doi:10.1016/j.str.2008.10.015|imex:IM-11793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15751144|imex:IM-11793-6|dip:DIP-102567E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137812(gene)|ensembl:ENST00000399668(transcript)|intact:EBI-1001161(isoform-parent)|uniprotkb:Q8NG31-2(isoform-parent)	ensembl:ENSP00000302530|ensembl:ENST00000409311|ensembl:ENSP00000386701|ensembl:ENST00000535254|ensembl:ENSP00000441013|refseq:NP_004327.1|refseq:NP_001265546.1|ensembl:ENSG00000169679(gene)|ensembl:ENST00000302759(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007063"(regulation of sister chromatid cohesion)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43683|rcsb pdb:2LAH|rcsb pdb:4A1G|rcsb pdb:4QPM|rcsb pdb:4R8Q|rcsb pdb:5DMZ|rcsb pdb:6F7B|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-24206N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:a+zajVOwKkY0QIqgiM6NOSUzqqY9606	rogid:hsbJZRz5kXxVI+ADgSaCoUfXE1o9606	rigid:tyie/w5oTRWdFwlbW1M1C23+/B4	false	binding-associated region:1-728	binding-associated region:1-189|mutation disrupting interaction:22-22,21-21,20-20|mutation disrupting interaction:49-49,45-45|mutation disrupting interaction:65-65|mutation disrupting interaction:95-95,93-93|mutation disrupting interaction:95-95,94-94,93-93	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)