#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0107"(surface plasmon resonance) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750854|imex:IM-11791-2|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0114"(x-ray crystallography) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750835|imex:IM-11791-1|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750873|imex:IM-11791-3|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0114"(x-ray crystallography) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750893|imex:IM-11791-4|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0107"(surface plasmon resonance) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750931|imex:IM-11791-6|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0107"(surface plasmon resonance) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750912|imex:IM-11791-5|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16871 uniprotkb:P13232 intact:EBI-80490|uniprotkb:Q6NSP4|ensembl:ENSP00000306157|uniprotkb:Q6SV45|uniprotkb:Q9UPC1|uniprotkb:B2RCS6|uniprotkb:Q6NWM0|uniprotkb:B4DVT1|uniprotkb:Q05CU8|uniprotkb:Q6NWM1|uniprotkb:Q6NWM2|uniprotkb:Q6NWM3 intact:EBI-80516|uniprotkb:A0N0L3|ensembl:ENSP00000263851|uniprotkb:Q5FBY9|uniprotkb:Q5FBY5 psi-mi:il7ra_human(display_long)|uniprotkb:IL7R(gene name)|psi-mi:IL7R(display_short)|uniprotkb:CDw127(gene name synonym) psi-mi:il7_human(display_long)|uniprotkb:IL7(gene name)|psi-mi:IL7(display_short) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) McElroy et al. (2009) pubmed:19141282|doi:10.1016/j.str.2008.10.019|imex:IM-11791 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15750950|imex:IM-11791-7|dip:DIP-4302E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168685(gene)|ensembl:ENST00000303115(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0003823"(antigen binding)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004917"(interleukin-7 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0042100"(B cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040997|mint:P16871|rcsb pdb:3DI2|rcsb pdb:3DI3|go:"GO:0005886"(plasma membrane)|rcsb pdb:5J11|rcsb pdb:6P50|rcsb pdb:6P67|reactome:R-HSA-1266695|reactome:R-HSA-8856825|reactome:R-HSA-8856828|rcsb pdb:3UP1|refseq:NP_002176.2|dip:DIP-3045N ensembl:ENSG00000104432(gene)|ensembl:ENST00000263851(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0005125"(cytokine activity)|go:"GO:0005139"(interleukin-7 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006959"(humoral immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001181(Interleukin-7)|interpro:IPR018049|rcsb pdb:1IL7|rcsb pdb:3DI2|rcsb pdb:3DI3|reactome:R-HSA-1266695|interpro:IPR038325|refseq:NP_000871.1|refseq:NP_001186815.1|refseq:NP_001186816.1|refseq:NP_001186817.1|dip:DIP-3044N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/09/20 rogid:8tfp5J+GYGrnzfuyfJhj8T+IMt89606 rogid:D4Hes6kPH7oMw9lNknQXbrVDXAE9606 rigid:0+rFkEd86JFu7QXBI02TKjb00g4 false binding-associated region:21-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)