#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9IW12	uniprotkb:Q14116	intact:EBI-15748155	intact:EBI-3910835|uniprotkb:Q6FGY3|uniprotkb:O75599|intact:EBI-11016725|uniprotkb:Q6WWJ7|ensembl:ENSP00000280357|ensembl:ENSP00000434161	psi-mi:q9iw12_9poxv(display_long)	psi-mi:il18_human(display_long)|uniprotkb:IL18(gene name)|psi-mi:IL18(display_short)|uniprotkb:IGIF(gene name synonym)|uniprotkb:IL1F4(gene name synonym)|uniprotkb:Iboctadekin(gene name synonym)|uniprotkb:Interferon gamma-inducing factor(gene name synonym)|uniprotkb:Interleukin-1 gamma(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Krumm et al. (2008)	pubmed:19104048|doi:10.1073/pnas.0809086106|imex:IM-14394	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15748162|imex:IM-14394-1|dip:DIP-103450E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008791(Orthopoxvirus interleukin 18 binding)|interpro:IPR013783(Immunoglobulin-like fold)|dip:DIP-48667N	refseq:XP_011541107.1|refseq:XP_011541108.1|refseq:NP_001553.1|refseq:NP_001230140.1|ensembl:ENSG00000150782(gene)|ensembl:ENST00000280357(transcript)|ensembl:ENST00000528832(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030431"(sleep)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045515"(interleukin-18 receptor binding)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000975(Interleukin-1)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR015529(Interleukin 18)|rcsb pdb:1J0S|rcsb pdb:2VXT|rcsb pdb:3F62|rcsb pdb:3WO2|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4EEE|rcsb pdb:4EKX|rcsb pdb:4HJJ|rcsb pdb:4R6U|rcsb pdb:4XFS|rcsb pdb:4XFT|rcsb pdb:4XFU|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9012546|reactome:R-HSA-9660826|dip:DIP-3785N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:eBr1eBdvwAgDWAMbm2UQVioT1PM12643	rogid:EVCxJD7iNTtAvALzE8GSjbFMWik9606	rigid:bYW/JyKFoDXj97ZGgf/Fu+UDjBQ	false	binding-associated region:21-126	binding-associated region:37-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9IW12	uniprotkb:Q14116	intact:EBI-15748155	intact:EBI-3910835|uniprotkb:Q6FGY3|uniprotkb:O75599|intact:EBI-11016725|uniprotkb:Q6WWJ7|ensembl:ENSP00000280357|ensembl:ENSP00000434161	psi-mi:q9iw12_9poxv(display_long)	psi-mi:il18_human(display_long)|uniprotkb:IL18(gene name)|psi-mi:IL18(display_short)|uniprotkb:IGIF(gene name synonym)|uniprotkb:IL1F4(gene name synonym)|uniprotkb:Iboctadekin(gene name synonym)|uniprotkb:Interferon gamma-inducing factor(gene name synonym)|uniprotkb:Interleukin-1 gamma(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Krumm et al. (2008)	pubmed:19104048|doi:10.1073/pnas.0809086106|imex:IM-14394	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15748183|imex:IM-14394-2|dip:DIP-103450E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008791(Orthopoxvirus interleukin 18 binding)|interpro:IPR013783(Immunoglobulin-like fold)|dip:DIP-48667N	refseq:XP_011541107.1|refseq:XP_011541108.1|refseq:NP_001553.1|refseq:NP_001230140.1|ensembl:ENSG00000150782(gene)|ensembl:ENST00000280357(transcript)|ensembl:ENST00000528832(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030431"(sleep)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045515"(interleukin-18 receptor binding)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR000975(Interleukin-1)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR015529(Interleukin 18)|rcsb pdb:1J0S|rcsb pdb:2VXT|rcsb pdb:3F62|rcsb pdb:3WO2|rcsb pdb:3WO3|rcsb pdb:3WO4|rcsb pdb:4EEE|rcsb pdb:4EKX|rcsb pdb:4HJJ|rcsb pdb:4R6U|rcsb pdb:4XFS|rcsb pdb:4XFT|rcsb pdb:4XFU|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9012546|reactome:R-HSA-9660826|dip:DIP-3785N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:eBr1eBdvwAgDWAMbm2UQVioT1PM12643	rogid:EVCxJD7iNTtAvALzE8GSjbFMWik9606	rigid:bYW/JyKFoDXj97ZGgf/Fu+UDjBQ	false	binding-associated region:21-126	binding-associated region:37-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)