#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11177-1	uniprotkb:P08559-1	intact:EBI-25766519	intact:EBI-25766512|ensembl:ENSP00000394382	psi-mi:p11177-1(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:p08559-1(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kato et al. (2008)	pubmed:19081061|doi:10.1016/j.str.2008.10.010|imex:IM-11798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15747079|imex:IM-11798-2|dip:DIP-65616E|wwpdb:3EXE|wwpdb:3EXF|wwpdb:3EXI	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P11177-1(isoform-parent)	ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|intact:EBI-715747(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 1,Fig 3,Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2020/08/03	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rigid:y+0XxrBlxXKzahh++mQOcfcV37Y	false	binding-associated region:31-359	mutation with no effect:300-300,232-232|mutation with no effect:118-118|binding-associated region:30-390|ha tag:n-n	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11177-1	uniprotkb:P08559-1	intact:EBI-25766519	intact:EBI-25766512|ensembl:ENSP00000394382	psi-mi:p11177-1(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:p08559-1(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kato et al. (2008)	pubmed:19081061|doi:10.1016/j.str.2008.10.010|imex:IM-11798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25766499|wwpdb:3EXG|wwpdb:3EXH|imex:IM-11798-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P11177-1(isoform-parent)	ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|intact:EBI-715747(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 3,Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2020/08/03	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rigid:y+0XxrBlxXKzahh++mQOcfcV37Y	false	binding-associated region:31-359	mutation with no effect:300-300,232-232|binding-associated region:30-390|ha tag:n-n|O-phospho-L-serine:293-293	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q16654	uniprotkb:P08559-1	intact:EBI-2861674|ensembl:ENSP00000005178	intact:EBI-25766512|ensembl:ENSP00000394382	psi-mi:pdk4_human(display_long)|uniprotkb:PDK4(gene name)|psi-mi:PDK4(display_short)|uniprotkb:PDHK4(gene name synonym)|uniprotkb:Pyruvate dehydrogenase kinase isoform 4(gene name synonym)	psi-mi:p08559-1(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0841"(phosphotransferase assay)	Kato et al. (2008)	pubmed:19081061|doi:10.1016/j.str.2008.10.010|imex:IM-11798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25767062|imex:IM-11798-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002603.1|interpro:IPR036784|interpro:IPR018955|interpro:IPR036890|interpro:IPR039028|rcsb pdb:2E0A|rcsb pdb:2ZDX|rcsb pdb:2ZDY|rcsb pdb:2ZKJ|rcsb pdb:3D2R|reactome:R-HSA-204174|reactome:R-HSA-5362517|ensembl:ENSG00000004799(gene)|ensembl:ENST00000005178(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0046320"(regulation of fatty acid oxidation)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)	ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|intact:EBI-715747(isoform-parent)	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2020/08/04	rogid:xAjJT16weTv1tdBqXnYGX/sfb8E9606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rigid:4phzj6tVgunFTv7d2fZkmeAj+n8	false	binding-associated region:10-411|his tag:n-n|sumo tag:n-n	binding-associated region:30-390|his tag:n-n|32p radiolabel:?-?|mutation:232-232,300-300|mutation:293-293,232-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11177-1	uniprotkb:P08559-1	intact:EBI-25766519	intact:EBI-25766512|ensembl:ENSP00000394382	psi-mi:p11177-1(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:p08559-1(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kato et al. (2008)	pubmed:19081061|doi:10.1016/j.str.2008.10.010|imex:IM-11798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25767107|imex:IM-11798-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P11177-1(isoform-parent)	ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|intact:EBI-715747(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2020/08/05	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rigid:y+0XxrBlxXKzahh++mQOcfcV37Y	false	binding-associated region:128-265|his tag:n-n|xpress tag:n-n	mutation with no effect:300-300,232-232|binding-associated region:30-390|ha tag:n-n	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P11177-1	uniprotkb:P08559-1	intact:EBI-25766519	intact:EBI-25766512|ensembl:ENSP00000394382	psi-mi:p11177-1(display_long)|uniprotkb:PDHB(gene name)|psi-mi:PDHB(display_short)|uniprotkb:PHE1B(gene name synonym)	psi-mi:p08559-1(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kato et al. (2008)	pubmed:19081061|doi:10.1016/j.str.2008.10.010|imex:IM-11798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25767123|imex:IM-11798-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:P11177-1(isoform-parent)	ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|intact:EBI-715747(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2020/08/05	rogid:VnabVXgFi4b43Wl37PzUX3+j4A89606	rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606	rigid:y+0XxrBlxXKzahh++mQOcfcV37Y	false	binding-associated region:128-265|his tag:n-n|xpress tag:n-n	mutation:300-300,232-232|binding-associated region:30-390|ha tag:n-n|O-phospho-L-serine:293-293	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)