#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20291	uniprotkb:P12527	intact:EBI-15746604|ensembl:ENSRNOP00000001207|uniprotkb:Q5RJL3	intact:EBI-15746572	psi-mi:al5ap_rat(display_long)|uniprotkb:Alox5ap(gene name)|psi-mi:Alox5ap(display_short)|uniprotkb:Flap(gene name synonym)|uniprotkb:FLAP(gene name synonym)|uniprotkb:MK-886-binding protein(gene name synonym)	psi-mi:lox5_rat(display_long)|uniprotkb:Alox5(gene name)|psi-mi:Alox5(display_short)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mandal et al. (2008)	pubmed:19075240|doi:10.1073/pnas.0808211106|imex:IM-14385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746644|imex:IM-14385-1|dip:DIP-103437E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000907(gene)|ensembl:ENSRNOT00000001207(transcript)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004464"(leukotriene-C4 synthase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001129("Membrane-associated, eicosanoid and glutathione metabolism (MAPEG)")|interpro:IPR001446(5-lipoxygenase-activating protein)|interpro:IPR018295|interpro:IPR023352|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|dip:DIP-48660N|refseq:NP_058956.1|rgd:2097	go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|reactome:R-RNO-6798695|reactome:R-RNO-9018896|dip:DIP-48659N|refseq:NP_036954.1|rgd:2096|reactome:R-RNO-9018676|reactome:R-RNO-9018682|reactome:R-RNO-9020265|reactome:R-RNO-9023661|reactome:R-RNO-9026286|reactome:R-RNO-9026290|reactome:R-RNO-9026403|reactome:R-RNO-9027604	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:/eC4JrAXMuvnbyUDKZtjjhx+76Q10116	rogid:AJGdYm6QMc6OGkgEF/fnz7CqZiE10116	rigid:TW4YNLfM4ai2or69TceYflTe/9k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20291	uniprotkb:P20291	intact:EBI-15746604|ensembl:ENSRNOP00000001207|uniprotkb:Q5RJL3	intact:EBI-15746604|ensembl:ENSRNOP00000001207|uniprotkb:Q5RJL3	psi-mi:al5ap_rat(display_long)|uniprotkb:Alox5ap(gene name)|psi-mi:Alox5ap(display_short)|uniprotkb:Flap(gene name synonym)|uniprotkb:FLAP(gene name synonym)|uniprotkb:MK-886-binding protein(gene name synonym)	psi-mi:al5ap_rat(display_long)|uniprotkb:Alox5ap(gene name)|psi-mi:Alox5ap(display_short)|uniprotkb:Flap(gene name synonym)|uniprotkb:FLAP(gene name synonym)|uniprotkb:MK-886-binding protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Mandal et al. (2008)	pubmed:19075240|doi:10.1073/pnas.0808211106|imex:IM-14385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746661|imex:IM-14385-2|dip:DIP-103438E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000907(gene)|ensembl:ENSRNOT00000001207(transcript)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004464"(leukotriene-C4 synthase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001129("Membrane-associated, eicosanoid and glutathione metabolism (MAPEG)")|interpro:IPR001446(5-lipoxygenase-activating protein)|interpro:IPR018295|interpro:IPR023352|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|dip:DIP-48660N|refseq:NP_058956.1|rgd:2097	ensembl:ENSRNOG00000000907(gene)|ensembl:ENSRNOT00000001207(transcript)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004464"(leukotriene-C4 synthase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001129("Membrane-associated, eicosanoid and glutathione metabolism (MAPEG)")|interpro:IPR001446(5-lipoxygenase-activating protein)|interpro:IPR018295|interpro:IPR023352|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|dip:DIP-48660N|refseq:NP_058956.1|rgd:2097	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:/eC4JrAXMuvnbyUDKZtjjhx+76Q10116	rogid:/eC4JrAXMuvnbyUDKZtjjhx+76Q10116	rigid:9dleo+BwNOtb2fjjDkGy5IDadJo	false	-	-	-	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20291	uniprotkb:P12527	intact:EBI-15746604|ensembl:ENSRNOP00000001207|uniprotkb:Q5RJL3	intact:EBI-15746572	psi-mi:al5ap_rat(display_long)|uniprotkb:Alox5ap(gene name)|psi-mi:Alox5ap(display_short)|uniprotkb:Flap(gene name synonym)|uniprotkb:FLAP(gene name synonym)|uniprotkb:MK-886-binding protein(gene name synonym)	psi-mi:lox5_rat(display_long)|uniprotkb:Alox5(gene name)|psi-mi:Alox5(display_short)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Mandal et al. (2008)	pubmed:19075240|doi:10.1073/pnas.0808211106|imex:IM-14385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746677|imex:IM-14385-3|dip:DIP-103437E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000907(gene)|ensembl:ENSRNOT00000001207(transcript)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004464"(leukotriene-C4 synthase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR001129("Membrane-associated, eicosanoid and glutathione metabolism (MAPEG)")|interpro:IPR001446(5-lipoxygenase-activating protein)|interpro:IPR018295|interpro:IPR023352|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|dip:DIP-48660N|refseq:NP_058956.1|rgd:2097	go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042383"(sarcolemma)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|reactome:R-RNO-2142688|reactome:R-RNO-2142691|reactome:R-RNO-2142700|reactome:R-RNO-6798695|reactome:R-RNO-9018896|dip:DIP-48659N|refseq:NP_036954.1|rgd:2096|reactome:R-RNO-9018676|reactome:R-RNO-9018682|reactome:R-RNO-9020265|reactome:R-RNO-9023661|reactome:R-RNO-9026286|reactome:R-RNO-9026290|reactome:R-RNO-9026403|reactome:R-RNO-9027604	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:/eC4JrAXMuvnbyUDKZtjjhx+76Q10116	rogid:AJGdYm6QMc6OGkgEF/fnz7CqZiE10116	rigid:TW4YNLfM4ai2or69TceYflTe/9k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)