#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q12967	uniprotkb:P04049	intact:EBI-365861|uniprotkb:Q9P2N8|uniprotkb:Q9HAX7|uniprotkb:Q9HAY1|uniprotkb:Q9HCT1|ensembl:ENSP00000361120|uniprotkb:B7Z753|uniprotkb:E7ER93|uniprotkb:E7ERZ0|uniprotkb:Q6PCE1|uniprotkb:Q6ZSD5|uniprotkb:Q5T7V4|uniprotkb:Q6KH11	intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3	psi-mi:gnds_human(display_long)|uniprotkb:RALGDS(gene name)|psi-mi:RALGDS(display_short)|uniprotkb:RGF(gene name synonym)|uniprotkb:KIAA1308(gene name synonym)|uniprotkb:Ral guanine nucleotide exchange factor(gene name synonym)	psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ye et al. (2008)	pubmed:19075231|doi:10.1073/pnas.0808110105|imex:IM-14384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746504|imex:IM-14384-1|dip:DIP-103436E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160271(gene)|ensembl:ENST00000372050(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030695"(GTPase regulator activity)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR015758(Guanine nucleotide dissociation stimulator RalGDS)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036964|rcsb pdb:1RAX|rcsb pdb:2B3A|rcsb pdb:2RGF|rcsb pdb:3KH0|reactome:R-HSA-171007|reactome:R-HSA-5673001|refseq:NP_006257.1|refseq:NP_001035827.1|refseq:NP_001258703.1|refseq:NP_001258705.1|ensembl:ENST00000372062|ensembl:ENSP00000361132|ensembl:ENST00000393157|ensembl:ENSP00000376864|ensembl:ENST00000393160|ensembl:ENSP00000376867|ensembl:ENSP00000361120|ensembl:ENST00000372047|ensembl:ENSP00000361117|refseq:NP_001258704.1|dip:DIP-31375N	rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7h1pcwLfOmg7huN2863/7lzWlyI9606	rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606	rigid:RSyyN3ADwK6ZiI9x7elRFFq8N0E	false	binding-associated region:798-885|glutathione s tranferase tag:n-n	binding-associated region:56-131|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12967	uniprotkb:A7U8D3	intact:EBI-365861|uniprotkb:Q9P2N8|uniprotkb:Q9HAX7|uniprotkb:Q9HAY1|uniprotkb:Q9HCT1|ensembl:ENSP00000361120|uniprotkb:B7Z753|uniprotkb:E7ER93|uniprotkb:E7ERZ0|uniprotkb:Q6PCE1|uniprotkb:Q6ZSD5|uniprotkb:Q5T7V4|uniprotkb:Q6KH11	intact:EBI-15746487	psi-mi:gnds_human(display_long)|uniprotkb:RALGDS(gene name)|psi-mi:RALGDS(display_short)|uniprotkb:RGF(gene name synonym)|uniprotkb:KIAA1308(gene name synonym)|uniprotkb:Ral guanine nucleotide exchange factor(gene name synonym)	psi-mi:a7u8d3_aplca(display_long)|uniprotkb:Rap(gene name)|psi-mi:Rap(display_short)	psi-mi:"MI:0096"(pull down)	Ye et al. (2008)	pubmed:19075231|doi:10.1073/pnas.0808110105|imex:IM-14384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6500(aplca)|taxid:6500("Aplysia californica (California sea hare)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746504|imex:IM-14384-1|dip:DIP-103436E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160271(gene)|ensembl:ENST00000372050(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030695"(GTPase regulator activity)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR015758(Guanine nucleotide dissociation stimulator RalGDS)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036964|rcsb pdb:1RAX|rcsb pdb:2B3A|rcsb pdb:2RGF|rcsb pdb:3KH0|reactome:R-HSA-171007|reactome:R-HSA-5673001|refseq:NP_006257.1|refseq:NP_001035827.1|refseq:NP_001258703.1|refseq:NP_001258705.1|ensembl:ENST00000372062|ensembl:ENSP00000361132|ensembl:ENST00000393157|ensembl:ENSP00000376864|ensembl:ENST00000393160|ensembl:ENSP00000376867|ensembl:ENSP00000361120|ensembl:ENST00000372047|ensembl:ENSP00000361117|refseq:NP_001258704.1|dip:DIP-31375N	go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0016020"(membrane)|go:"GO:0032486"(Rap protein signal transduction)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|dip:DIP-48658N|refseq:NP_001191473.1|refseq:XP_012935235.1|refseq:XP_012935236.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7h1pcwLfOmg7huN2863/7lzWlyI9606	rogid:jyqKM6pVwHy5KYheeTWUVEvYnIA6500	rigid:RSyyN3ADwK6ZiI9x7elRFFq8N0E	false	binding-associated region:798-885|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12967	uniprotkb:A7U8D2	intact:EBI-365861|uniprotkb:Q9P2N8|uniprotkb:Q9HAX7|uniprotkb:Q9HAY1|uniprotkb:Q9HCT1|ensembl:ENSP00000361120|uniprotkb:B7Z753|uniprotkb:E7ER93|uniprotkb:E7ERZ0|uniprotkb:Q6PCE1|uniprotkb:Q6ZSD5|uniprotkb:Q5T7V4|uniprotkb:Q6KH11	intact:EBI-15746472	psi-mi:gnds_human(display_long)|uniprotkb:RALGDS(gene name)|psi-mi:RALGDS(display_short)|uniprotkb:RGF(gene name synonym)|uniprotkb:KIAA1308(gene name synonym)|uniprotkb:Ral guanine nucleotide exchange factor(gene name synonym)	psi-mi:a7u8d2_aplca(display_long)|uniprotkb:Ras(gene name)|psi-mi:Ras(display_short)	psi-mi:"MI:0096"(pull down)	Ye et al. (2008)	pubmed:19075231|doi:10.1073/pnas.0808110105|imex:IM-14384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6500(aplca)|taxid:6500("Aplysia californica (California sea hare)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15746504|imex:IM-14384-1|dip:DIP-103436E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160271(gene)|ensembl:ENST00000372050(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030695"(GTPase regulator activity)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR015758(Guanine nucleotide dissociation stimulator RalGDS)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036964|rcsb pdb:1RAX|rcsb pdb:2B3A|rcsb pdb:2RGF|rcsb pdb:3KH0|reactome:R-HSA-171007|reactome:R-HSA-5673001|refseq:NP_006257.1|refseq:NP_001035827.1|refseq:NP_001258703.1|refseq:NP_001258705.1|ensembl:ENST00000372062|ensembl:ENSP00000361132|ensembl:ENST00000393157|ensembl:ENSP00000376864|ensembl:ENST00000393160|ensembl:ENSP00000376867|ensembl:ENSP00000361120|ensembl:ENST00000372047|ensembl:ENSP00000361117|refseq:NP_001258704.1|dip:DIP-31375N	go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|dip:DIP-48657N|refseq:NP_001191472.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7h1pcwLfOmg7huN2863/7lzWlyI9606	rogid:obg+Na4CKuXjnDxGY/twBwptHX06500	rigid:RSyyN3ADwK6ZiI9x7elRFFq8N0E	false	binding-associated region:798-885|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)