#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P47027 uniprotkb:Q04377 intact:EBI-25984|uniprotkb:Q05712|uniprotkb:D6VW94|ensemblfungi:YJL090C intact:EBI-35652|uniprotkb:D6VTC1|ensemblfungi:YDR499W psi-mi:dpb11_yeast(display_long)|uniprotkb:DPB11(gene name)|psi-mi:DPB11(display_short)|uniprotkb:J0918(orf name)|uniprotkb:YJL090C(locus name) psi-mi:lcd1_yeast(display_long)|uniprotkb:LCD1(gene name)|psi-mi:LCD1(display_short)|uniprotkb:Lethal, checkpoint-defective, DNA damage-sensitive protein 1(gene name synonym)|uniprotkb:DNA damage checkpoint protein 2(gene name synonym)|uniprotkb:YDR499W(locus name)|uniprotkb:DDC2(gene name synonym)|uniprotkb:PIE1(gene name synonym) psi-mi:"MI:0096"(pull down) Mordes et al. (2008) pubmed:19028869|doi:10.1073/pnas.0806621105|imex:IM-14368 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15742800|imex:IM-14368-1|dip:DIP-103337E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000003626|refseq:NP_012445.1|dip:DIP-5037N|ensemblfungi:YJL090C(gene)|ensemblfungi:YJL090C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000725"(recombinational repair)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007533"(mating type switching)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1902597"(positive regulation of DNA replication origin binding)|interpro:IPR001357(BRCT)|interpro:IPR036420 refseq:NP_010787.3|sgd:S000002907|mint:Q04377|dip:DIP-2970N|ensemblfungi:YDR499W(gene)|ensemblfungi:YDR499W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR018622|rcsb pdb:5OMD|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A psi-mi:"MI:0465"(dip) crc64:79B3A9BC7815E440 crc64:E981C1A38F3310BF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:CYn2Q78DOL/+HPutAsKRuKofolE559292 rogid:qx0fM2HHwEI/GtbjRXu8kQrSp5w559292 rigid:XQM0qJrlWc6Nqe5uIZSnj7qIQ6s false sufficient binding region:583-764|glutathione s tranferase tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P47027 uniprotkb:P38111 intact:EBI-25984|uniprotkb:Q05712|uniprotkb:D6VW94|ensemblfungi:YJL090C intact:EBI-6668|uniprotkb:Q02580|uniprotkb:D6VQD2|ensemblfungi:YBR136W psi-mi:dpb11_yeast(display_long)|uniprotkb:DPB11(gene name)|psi-mi:DPB11(display_short)|uniprotkb:J0918(orf name)|uniprotkb:YJL090C(locus name) psi-mi:atr_yeast(display_long)|uniprotkb:Mitosis entry checkpoint protein 1(gene name synonym)|uniprotkb:ATR homolog(gene name synonym)|uniprotkb:MEC1(gene name)|psi-mi:MEC1(display_short)|uniprotkb:ESR1(gene name synonym)|uniprotkb:SAD3(gene name synonym)|uniprotkb:YBR136W(locus name)|uniprotkb:YBR1012(orf name)|uniprotkb:DNA-damage checkpoint kinase MEC1(gene name synonym) psi-mi:"MI:0096"(pull down) Mordes et al. (2008) pubmed:19028869|doi:10.1073/pnas.0806621105|imex:IM-14368 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15742800|imex:IM-14368-1|dip:DIP-103337E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000003626|refseq:NP_012445.1|dip:DIP-5037N|ensemblfungi:YJL090C(gene)|ensemblfungi:YJL090C_mRNA(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000725"(recombinational repair)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005657"(replication fork)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007533"(mating type switching)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1902597"(positive regulation of DNA replication origin binding)|interpro:IPR001357(BRCT)|interpro:IPR036420 refseq:NP_009694.3|sgd:S000000340|dip:DIP-799N|mint:P38111|ensemblfungi:YBR136W(gene)|ensemblfungi:YBR136W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A psi-mi:"MI:0465"(dip) crc64:79B3A9BC7815E440 crc64:C06AEF9F0484A615 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:CYn2Q78DOL/+HPutAsKRuKofolE559292 rogid:BXSOV2x+FVvpAqOdHUGcYrTCN0A559292 rigid:XQM0qJrlWc6Nqe5uIZSnj7qIQ6s false sufficient binding region:583-764|glutathione s tranferase tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q04377 uniprotkb:P38111 intact:EBI-35652|uniprotkb:D6VTC1|ensemblfungi:YDR499W intact:EBI-6668|uniprotkb:Q02580|uniprotkb:D6VQD2|ensemblfungi:YBR136W psi-mi:lcd1_yeast(display_long)|uniprotkb:LCD1(gene name)|psi-mi:LCD1(display_short)|uniprotkb:Lethal, checkpoint-defective, DNA damage-sensitive protein 1(gene name synonym)|uniprotkb:DNA damage checkpoint protein 2(gene name synonym)|uniprotkb:YDR499W(locus name)|uniprotkb:DDC2(gene name synonym)|uniprotkb:PIE1(gene name synonym) psi-mi:atr_yeast(display_long)|uniprotkb:Mitosis entry checkpoint protein 1(gene name synonym)|uniprotkb:ATR homolog(gene name synonym)|uniprotkb:MEC1(gene name)|psi-mi:MEC1(display_short)|uniprotkb:ESR1(gene name synonym)|uniprotkb:SAD3(gene name synonym)|uniprotkb:YBR136W(locus name)|uniprotkb:YBR1012(orf name)|uniprotkb:DNA-damage checkpoint kinase MEC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mordes et al. (2008) pubmed:19028869|doi:10.1073/pnas.0806621105|imex:IM-14368 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15742826|imex:IM-14368-2|dip:DIP-10488E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010787.3|sgd:S000002907|mint:Q04377|dip:DIP-2970N|ensemblfungi:YDR499W(gene)|ensemblfungi:YDR499W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR018622|rcsb pdb:5OMD|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A refseq:NP_009694.3|sgd:S000000340|dip:DIP-799N|mint:P38111|ensemblfungi:YBR136W(gene)|ensemblfungi:YBR136W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A psi-mi:"MI:0465"(dip) crc64:E981C1A38F3310BF crc64:C06AEF9F0484A615 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:qx0fM2HHwEI/GtbjRXu8kQrSp5w559292 rogid:BXSOV2x+FVvpAqOdHUGcYrTCN0A559292 rigid:QTC8BxVajulQ/dpgaph2wZf+dIY false myc tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)