#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61810 uniprotkb:P04202 intact:EBI-11600622|uniprotkb:Q8BNQ6|ensembl:ENSMUSP00000080214|uniprotkb:F8VQ06 intact:EBI-12557919|ensembl:ENSMUSP00000002678 psi-mi:ltbp3_mouse(display_long)|uniprotkb:Ltbp3(gene name)|psi-mi:Ltbp3(display_short) psi-mi:tgfb1_mouse(display_long)|uniprotkb:Tgfb1(gene name)|psi-mi:Tgfb1(display_short) psi-mi:"MI:0808"(comigration in sds page) Yoshinaga et al. (2008) pubmed:19022904|doi:10.1073/pnas.0805411105|imex:IM-14366 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15742623|imex:IM-14366-1|dip:DIP-103334E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032546.2|ensembl:ENSMUSG00000024940(gene)|ensembl:ENSMUST00000081496(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0036363"(transforming growth factor beta activation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046849"(bone remodeling)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060430"(lung saccule development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:2000741"(positive regulation of mesenchymal stem cell differentiation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR036773|reactome:R-MMU-2129379|dip:DIP-48641N go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902074"(response to salt)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|reactome:R-MMU-114608|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-3000170|reactome:R-MMU-8941855|reactome:R-MMU-8941858|reactome:R-MMU-8951936|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|ensembl:ENSMUSG00000002603(gene)|ensembl:ENSMUST00000002678(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001775"(cell activation)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032829"(regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042493"|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0032355"(response to estradiol)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0060435"(bronchiole development)|go:"GO:0048565"(digestive tract development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048839"(inner ear development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072562"(blood microparticle)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050777"(negative regulation of immune response)|dip:DIP-48640N|refseq:NP_035707.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2019/01/24 rogid:Qd3EVkCCEbDUYJVpxp6cjRUsKdo10090 rogid:MmayyVMLbkrTb86cBI97uOFfevA10090 rigid:6hUCRPvttpKjDcVtlczZv4bu5Ek false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04202 uniprotkb:P04202 intact:EBI-12557919|ensembl:ENSMUSP00000002678 intact:EBI-12557919|ensembl:ENSMUSP00000002678 psi-mi:tgfb1_mouse(display_long)|uniprotkb:Tgfb1(gene name)|psi-mi:Tgfb1(display_short) psi-mi:tgfb1_mouse(display_long)|uniprotkb:Tgfb1(gene name)|psi-mi:Tgfb1(display_short) psi-mi:"MI:0808"(comigration in sds page) Yoshinaga et al. (2008) pubmed:19022904|doi:10.1073/pnas.0805411105|imex:IM-14366 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15742640|imex:IM-14366-2|dip:DIP-103335E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902074"(response to salt)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|reactome:R-MMU-114608|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-3000170|reactome:R-MMU-8941855|reactome:R-MMU-8941858|reactome:R-MMU-8951936|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|ensembl:ENSMUSG00000002603(gene)|ensembl:ENSMUST00000002678(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001775"(cell activation)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032829"(regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042493"|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0032355"(response to estradiol)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0060435"(bronchiole development)|go:"GO:0048565"(digestive tract development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048839"(inner ear development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072562"(blood microparticle)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050777"(negative regulation of immune response)|dip:DIP-48640N|refseq:NP_035707.1 go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097421"(liver regeneration)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902074"(response to salt)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903911"(positive regulation of receptor clustering)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|reactome:R-MMU-114608|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-3000170|reactome:R-MMU-8941855|reactome:R-MMU-8941858|reactome:R-MMU-8951936|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|ensembl:ENSMUSG00000002603(gene)|ensembl:ENSMUST00000002678(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001501"(skeletal system development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001775"(cell activation)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002069"(columnar/cuboidal epithelial cell maturation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002460"(adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032570"(response to progesterone)|go:"GO:0032667"(regulation of interleukin-23 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032829"(regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032943"(mononuclear cell proliferation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042482"(positive regulation of odontogenesis)|go:"GO:0042493"|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0032355"(response to estradiol)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0060435"(bronchiole development)|go:"GO:0048565"(digestive tract development)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060751"(branch elongation involved in mammary gland duct branching)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048839"(inner ear development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070166"(enamel mineralization)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0072562"(blood microparticle)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050777"(negative regulation of immune response)|dip:DIP-48640N|refseq:NP_035707.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:MmayyVMLbkrTb86cBI97uOFfevA10090 rogid:MmayyVMLbkrTb86cBI97uOFfevA10090 rigid:pKCtYc0rUlyDVEImR1gJheXcgUA false - - - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)