#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q64537	uniprotkb:Q07009	intact:EBI-918712|uniprotkb:P97572|uniprotkb:Q4V795	intact:EBI-1040438|ensembl:ENSRNOP00000046509	psi-mi:cpns1_rat(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:Capns1(gene name)|psi-mi:Capns1(display_short)|uniprotkb:Capn4(gene name synonym)|uniprotkb:Css1(gene name synonym)	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742260|imex:IM-17858-1|dip:DIP-11008E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2270|refseq:NP_058814.1|refseq:XP_017445520.1|dip:DIP-6140N|reactome:R-RNO-1474228|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|rcsb pdb:1AJ5|rcsb pdb:1DF0|rcsb pdb:1DVI|rcsb pdb:1NP8|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:+XfXCHyp2hPFnx9wiagwOOj38NI10116	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rigid:udNs7qTZjxKQ5HO9srGWZh4xvf8	false	binding-associated region:87-270	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:Q64537	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-918712|uniprotkb:P97572|uniprotkb:Q4V795	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:cpns1_rat(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:Capns1(gene name)|psi-mi:Capns1(display_short)|uniprotkb:Capn4(gene name synonym)|uniprotkb:Css1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742301|imex:IM-17858-3|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	rgd:2270|refseq:NP_058814.1|refseq:XP_017445520.1|dip:DIP-6140N|reactome:R-RNO-1474228|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|rcsb pdb:1AJ5|rcsb pdb:1DF0|rcsb pdb:1DVI|rcsb pdb:1NP8|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:+XfXCHyp2hPFnx9wiagwOOj38NI10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:87-270	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:P27321	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-7441624|uniprotkb:A5GXY7|uniprotkb:Q99MG1|uniprotkb:O55152|uniprotkb:A5GXY8|uniprotkb:A5GXY9|uniprotkb:A5GXY4|uniprotkb:Q5BK19|uniprotkb:A5GXZ7|uniprotkb:O55151|uniprotkb:A5GXY5|uniprotkb:A5GXY6|uniprotkb:O55153|uniprotkb:Q99MG2|intact:MINT-4820577	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:ical_rat(display_long)|uniprotkb:Cast(gene name)|psi-mi:Cast(display_short)|uniprotkb:Calpain inhibitor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742301|imex:IM-17858-3|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	mint:P27321|refseq:NP_445747.2|refseq:NP_001028888.1|rgd:2278|refseq:NP_001028887.1|go:"GO:0001889"(liver development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007343"(egg activation)|go:"GO:0007420"(brain development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007568"(aging)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010859"(calcium-dependent cysteine-type endopeptidase inhibitor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001259(Proteinase inhibitor I27, calpastatin)|interpro:IPR026998|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-44338N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:I25gP+WNXtt1IspArRrr72ZZD4w10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:193-278	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:Q64537	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-918712|uniprotkb:P97572|uniprotkb:Q4V795	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:cpns1_rat(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:Capns1(gene name)|psi-mi:Capns1(display_short)|uniprotkb:Capn4(gene name synonym)|uniprotkb:Css1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742279|imex:IM-17858-2|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	rgd:2270|refseq:NP_058814.1|refseq:XP_017445520.1|dip:DIP-6140N|reactome:R-RNO-1474228|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|rcsb pdb:1AJ5|rcsb pdb:1DF0|rcsb pdb:1DVI|rcsb pdb:1NP8|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:+XfXCHyp2hPFnx9wiagwOOj38NI10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:87-270	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:P27321	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-7441624|uniprotkb:A5GXY7|uniprotkb:Q99MG1|uniprotkb:O55152|uniprotkb:A5GXY8|uniprotkb:A5GXY9|uniprotkb:A5GXY4|uniprotkb:Q5BK19|uniprotkb:A5GXZ7|uniprotkb:O55151|uniprotkb:A5GXY5|uniprotkb:A5GXY6|uniprotkb:O55153|uniprotkb:Q99MG2|intact:MINT-4820577	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:ical_rat(display_long)|uniprotkb:Cast(gene name)|psi-mi:Cast(display_short)|uniprotkb:Calpain inhibitor(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742279|imex:IM-17858-2|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	mint:P27321|refseq:NP_445747.2|refseq:NP_001028888.1|rgd:2278|refseq:NP_001028887.1|go:"GO:0001889"(liver development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007343"(egg activation)|go:"GO:0007420"(brain development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007568"(aging)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010859"(calcium-dependent cysteine-type endopeptidase inhibitor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001259(Proteinase inhibitor I27, calpastatin)|interpro:IPR026998|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-44338N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:I25gP+WNXtt1IspArRrr72ZZD4w10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:193-278	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:Q64537	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-918712|uniprotkb:P97572|uniprotkb:Q4V795	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:cpns1_rat(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:Capns1(gene name)|psi-mi:Capns1(display_short)|uniprotkb:Capn4(gene name synonym)|uniprotkb:Css1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742324|imex:IM-17858-4|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	rgd:2270|refseq:NP_058814.1|refseq:XP_017445520.1|dip:DIP-6140N|reactome:R-RNO-1474228|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|rcsb pdb:1AJ5|rcsb pdb:1DF0|rcsb pdb:1DVI|rcsb pdb:1NP8|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:+XfXCHyp2hPFnx9wiagwOOj38NI10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:87-270	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07009	uniprotkb:P27321	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-7441624|uniprotkb:A5GXY7|uniprotkb:Q99MG1|uniprotkb:O55152|uniprotkb:A5GXY8|uniprotkb:A5GXY9|uniprotkb:A5GXY4|uniprotkb:Q5BK19|uniprotkb:A5GXZ7|uniprotkb:O55151|uniprotkb:A5GXY5|uniprotkb:A5GXY6|uniprotkb:O55153|uniprotkb:Q99MG2|intact:MINT-4820577	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:ical_rat(display_long)|uniprotkb:Cast(gene name)|psi-mi:Cast(display_short)|uniprotkb:Calpain inhibitor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Moldoveanu et al. (2008)	pubmed:19020622|doi:10.1038/nature07353|imex:IM-17858	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15742324|imex:IM-17858-4|dip:DIP-189304E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	mint:P27321|refseq:NP_445747.2|refseq:NP_001028888.1|rgd:2278|refseq:NP_001028887.1|go:"GO:0001889"(liver development)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007343"(egg activation)|go:"GO:0007420"(brain development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007568"(aging)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010859"(calcium-dependent cysteine-type endopeptidase inhibitor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001259(Proteinase inhibitor I27, calpastatin)|interpro:IPR026998|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-44338N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:I25gP+WNXtt1IspArRrr72ZZD4w10116	rigid:MwvWXUuURd4TDtZ0G3I+jKFdFpE	false	-	binding-associated region:193-278	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)