#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7KZI7	uniprotkb:Q15139	intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751	intact:EBI-1181072|uniprotkb:A6NL64|uniprotkb:B2RAF6|ensembl:ENSP00000333568|ensembl:ENSP00000482645	psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym)	psi-mi:kpcd1_human(display_long)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)|uniprotkb:PRKD1(gene name)|psi-mi:PRKD1(display_short)|uniprotkb:PKD(gene name synonym)|uniprotkb:PKD1(gene name synonym)|uniprotkb:PRKCM(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Watkins et al. (2008)	pubmed:19011111|doi:10.1073/pnas.0809661105|imex:IM-14358	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740789|imex:IM-14358-1|dip:DIP-103313E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8	refseq:NP_002733.2|ensembl:ENSG00000184304(gene)|ensembl:ENST00000331968(transcript)|ensembl:ENST00000616995(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0006915"(apoptotic process)|reactome:R-HSA-1660661|interpro:IPR020454|dip:DIP-38481N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606	rogid:L92XaEb6RJRv/HwB9Z56hiEl3jI9606	rigid:qVws0jYZKce6u/D7sc3mcEsMoNg	false	O-phospho-L-serine:400-400	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q02156	uniprotkb:Q15139	intact:EBI-706254|uniprotkb:Q32MQ3|uniprotkb:Q53SL4|uniprotkb:Q53SM5|uniprotkb:Q9UE81|uniprotkb:B0LPH7|ensembl:ENSP00000306124	intact:EBI-1181072|uniprotkb:A6NL64|uniprotkb:B2RAF6|ensembl:ENSP00000333568|ensembl:ENSP00000482645	psi-mi:kpce_human(display_long)|uniprotkb:nPKC-epsilon(gene name synonym)|uniprotkb:PRKCE(gene name)|psi-mi:PRKCE(display_short)|uniprotkb:PKCE(gene name synonym)	psi-mi:kpcd1_human(display_long)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)|uniprotkb:PRKD1(gene name)|psi-mi:PRKD1(display_short)|uniprotkb:PKD(gene name synonym)|uniprotkb:PKD1(gene name synonym)|uniprotkb:PRKCM(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Watkins et al. (2008)	pubmed:19011111|doi:10.1073/pnas.0809661105|imex:IM-14358	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740808|imex:IM-14358-2|dip:DIP-69045E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005391.1|refseq:XP_005264485.1|dip:DIP-34186N|ensembl:ENSG00000171132(gene)|ensembl:ENST00000306156(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051301"(cell division)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|mint:Q02156|rcsb pdb:2WH0|rcsb pdb:5LIH|reactome:R-HSA-114508|reactome:R-HSA-1250196|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-418597	refseq:NP_002733.2|ensembl:ENSG00000184304(gene)|ensembl:ENST00000331968(transcript)|ensembl:ENST00000616995(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0006915"(apoptotic process)|reactome:R-HSA-1660661|interpro:IPR020454|dip:DIP-38481N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IYps+mNGHlGam8YJiz/veQbq1s49606	rogid:L92XaEb6RJRv/HwB9Z56hiEl3jI9606	rigid:sSLkWf0YaevITNW6Jfmbb6zJqdQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)