#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60994	uniprotkb:Q96A54	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-1632076|uniprotkb:Q9Y360|uniprotkb:B3KMB0|uniprotkb:Q53HS7|uniprotkb:Q53YY6|ensembl:ENSP00000341785	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:paqr1_human(display_long)|uniprotkb:ADIPOR1(gene name)|psi-mi:ADIPOR1(display_short)|uniprotkb:PAQR1(gene name synonym)|uniprotkb:CGI-45(orf name)|uniprotkb:Progestin and adipoQ receptor family member I(gene name synonym)|uniprotkb:TESBP1A(gene name synonym)|uniprotkb:Progestin and adipoQ receptor family member 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740243|imex:IM-14356-1|dip:DIP-103308E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_001277482.1|refseq:NP_001277486.1|refseq:NP_001277558.1|refseq:NP_057083.2|dip:DIP-48622N|ensembl:ENSG00000159346(gene)|ensembl:ENST00000340990(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0055100"(adiponectin binding)|go:"GO:0097003"(adipokinetic hormone receptor activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004254(Hly-III related)|mint:Q96A54|rcsb pdb:5LXG|rcsb pdb:6KRZ|rcsb pdb:6KS0|reactome:R-HSA-163680	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:cwGOTdI1IOoJh6ru/aDwj+aC3Ro9606	rigid:A6dqIWwrnl7eMGunfpWhi8eAb/A	false	binding-associated region:17-247	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740262|imex:IM-14356-2|dip:DIP-74913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	ha tag:n-n	ha tag:n-n	-	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9DCM2	uniprotkb:Q60994	intact:EBI-8369416|intact:MINT-1860526|ensembl:ENSMUSP00000031897	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:gstk1_mouse(display_long)|uniprotkb:Gstk1(gene name)|psi-mi:Gstk1(display_short)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740280|imex:IM-14356-3|dip:DIP-103309E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083831.1|dip:DIP-48623N|ensembl:ENSMUSG00000029864(gene)|ensembl:ENSMUST00000031897(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|mint:Q9DCM2|reactome:R-MMU-156590|reactome:R-MMU-9033241	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:E6T8R4NRNqA0GZ1+HgS4x8K7/es10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:jr2UnJP0qulvMTWSTEvq6yIJHUY	false	myc tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740301|imex:IM-14356-4|dip:DIP-74913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	flag tag:n-n	flag tag:n-n	-	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740319|imex:IM-14356-5|dip:DIP-74913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	ha tag:n-n	ha tag:n-n	-	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9DCM2	uniprotkb:Q60994	intact:EBI-8369416|intact:MINT-1860526|ensembl:ENSMUSP00000031897	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:gstk1_mouse(display_long)|uniprotkb:Gstk1(gene name)|psi-mi:Gstk1(display_short)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0096"(pull down)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740337|imex:IM-14356-6|dip:DIP-103309E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083831.1|dip:DIP-48623N|ensembl:ENSMUSG00000029864(gene)|ensembl:ENSMUST00000031897(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|mint:Q9DCM2|reactome:R-MMU-156590|reactome:R-MMU-9033241	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:E6T8R4NRNqA0GZ1+HgS4x8K7/es10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:jr2UnJP0qulvMTWSTEvq6yIJHUY	false	his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740356|imex:IM-14356-7|dip:DIP-74913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	-	-	-	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60994	uniprotkb:Q9Y2Q3	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-1053767|uniprotkb:Q7Z520|uniprotkb:Q6P4H0|uniprotkb:Q9P1S4|uniprotkb:B4DIH1|uniprotkb:B4DSY2|ensembl:ENSP00000351181	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:gstk1_human(display_long)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)|uniprotkb:GSTK1(gene name)|psi-mi:GSTK1(display_short)|uniprotkb:HDCMD47P(orf name)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740372|imex:IM-14356-8|dip:DIP-103310E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_001137151.1|refseq:NP_001137152.1|refseq:NP_001137153.1|refseq:NP_057001.1|ensembl:ENSG00000197448(gene)|ensembl:ENST00000358406(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|rcsb pdb:1YZX|rcsb pdb:3RPN|rcsb pdb:3RPP|reactome:R-HSA-156590|reactome:R-HSA-9033241|dip:DIP-46924N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:aTjqqss32Y4bcsXg6gYlazahVCw9606	rigid:ZcU5/YRxOCYveB2Uru1V3b1w+wI	false	binding-associated region:17-247	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60994	uniprotkb:Q9DCM2	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-8369416|intact:MINT-1860526|ensembl:ENSMUSP00000031897	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:gstk1_mouse(display_long)|uniprotkb:Gstk1(gene name)|psi-mi:Gstk1(display_short)|uniprotkb:Glutathione S-transferase subunit 13(gene name synonym)|uniprotkb:GST 13-13(gene name synonym)|uniprotkb:GST class-kappa(gene name synonym)|uniprotkb:GSTK1-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740391|imex:IM-14356-9|dip:DIP-103309E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_083831.1|dip:DIP-48623N|ensembl:ENSMUSG00000029864(gene)|ensembl:ENSMUST00000031897(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0030855"(epithelial cell differentiation)|interpro:IPR001853(DSBA oxidoreductase)|interpro:IPR014440(HCCA isomerase/glutathione S-transferase kappa)|interpro:IPR036249|interpro:IPR044088|mint:Q9DCM2|reactome:R-MMU-156590|reactome:R-MMU-9033241	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:E6T8R4NRNqA0GZ1+HgS4x8K7/es10090	rigid:jr2UnJP0qulvMTWSTEvq6yIJHUY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Liu et al. (2008)	pubmed:19011089|doi:10.1073/pnas.0806341105|imex:IM-14356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15740408|imex:IM-14356-10|dip:DIP-74913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N	psi-mi:"MI:0465"(dip)	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/06	2017/08/10	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	-	-	-	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)