#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02879 uniprotkb:P19120 intact:EBI-8031741|intact:MINT-8391414|uniprotkb:P02880 intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4 psi-mi:rici_ricco(display_long) psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Spooner et al. (2008) pubmed:18988734|doi:10.1073/pnas.0809013105|imex:IM-9668 taxid:3988(castor bean)|taxid:3988(Ricinus communis) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15738901|imex:IM-9668-1|dip:DIP-88420E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001310630.1|dip:DIP-46421N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006952"(defense response)|go:"GO:0016208"(AMP binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030598"(rRNA N-glycosylase activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0090729"(toxin activity)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001574(Ribosome-inactivating protein)|interpro:IPR016138(Ribosome-inactivating protein, subdomain 1)|interpro:IPR016139(Ribosome-inactivating protein, subdomain 2)|interpro:IPR017988|interpro:IPR017989|interpro:IPR035992|interpro:IPR036041|rcsb pdb:1BR5|rcsb pdb:1BR6|rcsb pdb:1IFS|rcsb pdb:1IFT|rcsb pdb:1IFU|rcsb pdb:1IL3|rcsb pdb:1IL4|rcsb pdb:1IL5|rcsb pdb:1IL9|rcsb pdb:1J1M|rcsb pdb:1OBS|rcsb pdb:1OBT|rcsb pdb:1RTC|rcsb pdb:1UQ4|rcsb pdb:1UQ5|rcsb pdb:2AAI|rcsb pdb:2P8N|rcsb pdb:2PJO|rcsb pdb:2R2X|rcsb pdb:2R3D|rcsb pdb:2VC3|rcsb pdb:2VC4|rcsb pdb:3EJ5|rcsb pdb:3HIO|rcsb pdb:3LC9|rcsb pdb:3MK9|rcsb pdb:3PX8|rcsb pdb:3PX9|rcsb pdb:3RTI|rcsb pdb:3RTJ|rcsb pdb:3SRP|rcsb pdb:4ESI|rcsb pdb:4HUO|rcsb pdb:4HUP|rcsb pdb:4HV3|rcsb pdb:4HV7|rcsb pdb:4IMV|rcsb pdb:4KUC|rcsb pdb:4LGP|rcsb pdb:4LGR|rcsb pdb:4LGS|rcsb pdb:4LHJ|rcsb pdb:4LHQ|rcsb pdb:4MX1|rcsb pdb:4MX5|rcsb pdb:4Q2V|rcsb pdb:4Z9K|rcsb pdb:5BOZ|rcsb pdb:5DDZ|rcsb pdb:5E1H|rcsb pdb:5GU4|rcsb pdb:5J56|rcsb pdb:5J57|rcsb pdb:5SV3|rcsb pdb:5U4L|rcsb pdb:5U4M|rcsb pdb:6CWG|rcsb pdb:6OBC|rcsb pdb:6OBE|rcsb pdb:6OBG|rcsb pdb:6OBM|rcsb pdb:6OBO|rcsb pdb:6OCA|rcsb pdb:6OCD|rcsb pdb:6URW|rcsb pdb:6URX|rcsb pdb:6URY ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Tsx4eu5f2/z6Y+evPMtwtgEPdOs3988 rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913 rigid:fOW0xHJEFOW0KuarfJjydhodksw false binding-associated region:36-302 - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:P02879 uniprotkb:P25685 intact:EBI-8031741|intact:MINT-8391414|uniprotkb:P02880 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:rici_ricco(display_long) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Spooner et al. (2008) pubmed:18988734|doi:10.1073/pnas.0809013105|imex:IM-9668 taxid:3988(castor bean)|taxid:3988(Ricinus communis) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15738920|imex:IM-9668-2|dip:DIP-88421E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001310630.1|dip:DIP-46421N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006952"(defense response)|go:"GO:0016208"(AMP binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030598"(rRNA N-glycosylase activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0090729"(toxin activity)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001574(Ribosome-inactivating protein)|interpro:IPR016138(Ribosome-inactivating protein, subdomain 1)|interpro:IPR016139(Ribosome-inactivating protein, subdomain 2)|interpro:IPR017988|interpro:IPR017989|interpro:IPR035992|interpro:IPR036041|rcsb pdb:1BR5|rcsb pdb:1BR6|rcsb pdb:1IFS|rcsb pdb:1IFT|rcsb pdb:1IFU|rcsb pdb:1IL3|rcsb pdb:1IL4|rcsb pdb:1IL5|rcsb pdb:1IL9|rcsb pdb:1J1M|rcsb pdb:1OBS|rcsb pdb:1OBT|rcsb pdb:1RTC|rcsb pdb:1UQ4|rcsb pdb:1UQ5|rcsb pdb:2AAI|rcsb pdb:2P8N|rcsb pdb:2PJO|rcsb pdb:2R2X|rcsb pdb:2R3D|rcsb pdb:2VC3|rcsb pdb:2VC4|rcsb pdb:3EJ5|rcsb pdb:3HIO|rcsb pdb:3LC9|rcsb pdb:3MK9|rcsb pdb:3PX8|rcsb pdb:3PX9|rcsb pdb:3RTI|rcsb pdb:3RTJ|rcsb pdb:3SRP|rcsb pdb:4ESI|rcsb pdb:4HUO|rcsb pdb:4HUP|rcsb pdb:4HV3|rcsb pdb:4HV7|rcsb pdb:4IMV|rcsb pdb:4KUC|rcsb pdb:4LGP|rcsb pdb:4LGR|rcsb pdb:4LGS|rcsb pdb:4LHJ|rcsb pdb:4LHQ|rcsb pdb:4MX1|rcsb pdb:4MX5|rcsb pdb:4Q2V|rcsb pdb:4Z9K|rcsb pdb:5BOZ|rcsb pdb:5DDZ|rcsb pdb:5E1H|rcsb pdb:5GU4|rcsb pdb:5J56|rcsb pdb:5J57|rcsb pdb:5SV3|rcsb pdb:5U4L|rcsb pdb:5U4M|rcsb pdb:6CWG|rcsb pdb:6OBC|rcsb pdb:6OBE|rcsb pdb:6OBG|rcsb pdb:6OBM|rcsb pdb:6OBO|rcsb pdb:6OCA|rcsb pdb:6OCD|rcsb pdb:6URW|rcsb pdb:6URX|rcsb pdb:6URY dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:Tsx4eu5f2/z6Y+evPMtwtgEPdOs3988 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 rigid:vFwSBj99ah+KsIuRFH0cgN3gY+U false binding-associated region:36-302 - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining)