#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P54132 uniprotkb:Q9UQ84 intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96 intact:EBI-944667|uniprotkb:O60545|uniprotkb:O75214|uniprotkb:O75466|uniprotkb:Q5T396|uniprotkb:Q96IJ1|uniprotkb:Q9UG38|uniprotkb:Q9UNW0|ensembl:ENSP00000311873|ensembl:ENSP00000355506 psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym) psi-mi:exo1_human(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:EXOI(gene name synonym)|uniprotkb:HEX1(gene name synonym)|uniprotkb:Exonuclease I(gene name synonym) psi-mi:"MI:0096"(pull down) Nimonkar et al. (2008) pubmed:18971343|doi:10.1073/pnas.0809380105|imex:IM-22474 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15738116|imex:IM-22474-1|dip:DIP-196232E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N refseq:NP_003677.4|refseq:NP_006018.4|refseq:NP_569082.2|refseq:XP_006711903.1|refseq:XP_011542623.1|refseq:XP_011542624.1|dip:DIP-36701N|ensembl:ENSG00000174371(gene)|ensembl:ENST00000348581(transcript)|ensembl:ENST00000366548(transcript)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016604"(nuclear body)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0045145"(single-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:0045190"(isotype switching)|go:"GO:0046872"(metal ion binding)|go:"GO:0048256"(flap endonuclease activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051908"(double-stranded DNA 5'-3' exodeoxyribonuclease activity)|go:"GO:0090656"(t-circle formation)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:3QE9|rcsb pdb:3QEA|rcsb pdb:3QEB|rcsb pdb:5UZV|rcsb pdb:5V04|rcsb pdb:5V05|rcsb pdb:5V06|rcsb pdb:5V07|rcsb pdb:5V08|rcsb pdb:5V09|rcsb pdb:5V0A|rcsb pdb:5V0B|rcsb pdb:5V0C|rcsb pdb:5V0D|rcsb pdb:5V0E|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606 rogid:fvuFXVLS3mhyuaULAvHba1VPw8M9606 rigid:uSWOIlob4+Q+w7nI2mSBW11gTOw false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining)