#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q155Z9 uniprotkb:Q155Z9 intact:EBI-15735447 intact:EBI-15735447 psi-mi:polg_svv1(display_long) psi-mi:polg_svv1(display_long) psi-mi:"MI:0114"(x-ray crystallography) Venkataraman et al. (2008) pubmed:18940610|doi:10.1016/j.str.2008.07.013|imex:IM-9489 taxid:686944(svv1)|taxid:686944(svv1) taxid:686944(svv1)|taxid:686944(svv1) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15735484|imex:IM-9489-1|dip:DIP-88146E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0016020"(membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|go:"GO:0039538"|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|interpro:IPR001676(Picornavirus capsid)|go:"GO:0039547"(suppression by virus of host TRAF activity)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR029053|interpro:IPR033703|interpro:IPR037080|interpro:IPR043128|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067|rcsb pdb:3CJI|rcsb pdb:6ADL|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|rcsb pdb:6L0T|go:"GO:0039617"(T=3 icosahedral viral capsid)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|dip:DIP-46244N|refseq:YP_002268402.1 go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0016020"(membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|go:"GO:0039538"|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|interpro:IPR001676(Picornavirus capsid)|go:"GO:0039547"(suppression by virus of host TRAF activity)|interpro:IPR004004(Helicase/polymerase/peptidase polyprotein, Calicivirus)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR027417|interpro:IPR029053|interpro:IPR033703|interpro:IPR037080|interpro:IPR043128|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067|rcsb pdb:3CJI|rcsb pdb:6ADL|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|rcsb pdb:6L0T|go:"GO:0039617"(T=3 icosahedral viral capsid)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|dip:DIP-46244N|refseq:YP_002268402.1 psi-mi:"MI:0465"(dip) crc64:FA8BF3068931AB9A crc64:FA8BF3068931AB9A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:lzIBqoykgcO21QeZO6F42QfnPd8686944 rogid:lzIBqoykgcO21QeZO6F42QfnPd8686944 rigid:m7le183zWZDRxZCqhckIJULCBWI false polyprotein fragment:79-150|polyprotein fragment:151-434|polyprotein fragment:435-673|polyprotein fragment:674-936 polyprotein fragment:79-150|polyprotein fragment:151-434|polyprotein fragment:435-673|polyprotein fragment:674-936 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)