#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:D3ZZY5	uniprotkb:P55215	intact:EBI-15732799|ensembl:ENSRNOP00000025291|ensembl:ENSRNOP00000065320	intact:EBI-15732853|ensembl:ENSRNOP00000022672|uniprotkb:O35398|uniprotkb:O55194|uniprotkb:Q9WUI6	psi-mi:d3zzy5_rat(display_long)|uniprotkb:Pidd1(gene name)|psi-mi:Pidd1(display_short)|uniprotkb:LOC100911519(gene name synonym)	psi-mi:casp2_rat(display_long)|uniprotkb:Casp2(gene name)|psi-mi:Casp2(display_short)|uniprotkb:Ich1(gene name synonym)|uniprotkb:Protease ICH-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Niizuma et al. (2008)	pubmed:18845684|doi:10.1073/pnas.0806222105|imex:IM-14341	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15732900|imex:IM-14341-1|dip:DIP-103272E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000018710(gene)|ensembl:ENSRNOG00000049179(gene)|ensembl:ENSRNOT00000025290(transcript)|ensembl:ENSRNOT00000072774(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011029(DEATH-like)|interpro:IPR019502|interpro:IPR032675|reactome:R-RNO-6803207|refseq:NP_001099788.2|refseq:XP_003749059.1|refseq:XP_008772966.1|rgd:1311792|rgd:6492303|dip:DIP-48600N	ensembl:ENSRNOG00000016707(gene)|ensembl:ENSRNOT00000022672(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0003407"(neural retina development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035702|reactome:R-RNO-168638|reactome:R-RNO-205025|reactome:R-RNO-6803207|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rgd:69274|refseq:NP_071967.2|dip:DIP-48602N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:R5H5gYEB5wSWw3DH0fn4r8TacS410116	rogid:ZNIUFaw1pJ8CgILlXc7yNn0aOZA10116	rigid:6n+JFTGp8nOmxED2y3fQBVvuKUw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D3ZZY5	uniprotkb:D3ZB14	intact:EBI-15732799|ensembl:ENSRNOP00000025291|ensembl:ENSRNOP00000065320	intact:EBI-15732828|ensembl:ENSRNOP00000062865	psi-mi:d3zzy5_rat(display_long)|uniprotkb:Pidd1(gene name)|psi-mi:Pidd1(display_short)|uniprotkb:LOC100911519(gene name synonym)	psi-mi:d3zb14_rat(display_long)|uniprotkb:Cradd(gene name)|psi-mi:Cradd(display_short)|uniprotkb:Cradd_predicted(gene name synonym)|uniprotkb:rCG_48999(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Niizuma et al. (2008)	pubmed:18845684|doi:10.1073/pnas.0806222105|imex:IM-14341	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15732900|imex:IM-14341-1|dip:DIP-103272E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000018710(gene)|ensembl:ENSRNOG00000049179(gene)|ensembl:ENSRNOT00000025290(transcript)|ensembl:ENSRNOT00000072774(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011029(DEATH-like)|interpro:IPR019502|interpro:IPR032675|reactome:R-RNO-6803207|refseq:NP_001099788.2|refseq:XP_003749059.1|refseq:XP_008772966.1|rgd:1311792|rgd:6492303|dip:DIP-48600N	ensembl:ENSRNOG00000008507(gene)|ensembl:ENSRNOT00000063946(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0070513"(death domain binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR037939|interpro:IPR042148|reactome:R-RNO-6803207|rgd:1311010|refseq:NP_001101555.1|dip:DIP-48601N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:R5H5gYEB5wSWw3DH0fn4r8TacS410116	rogid:ElyRtZyZyq2hMko/t9ztSzqcktM10116	rigid:6n+JFTGp8nOmxED2y3fQBVvuKUw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55215	uniprotkb:D3ZB14	intact:EBI-15732853|ensembl:ENSRNOP00000022672|uniprotkb:O35398|uniprotkb:O55194|uniprotkb:Q9WUI6	intact:EBI-15732828|ensembl:ENSRNOP00000062865	psi-mi:casp2_rat(display_long)|uniprotkb:Casp2(gene name)|psi-mi:Casp2(display_short)|uniprotkb:Ich1(gene name synonym)|uniprotkb:Protease ICH-1(gene name synonym)	psi-mi:d3zb14_rat(display_long)|uniprotkb:Cradd(gene name)|psi-mi:Cradd(display_short)|uniprotkb:Cradd_predicted(gene name synonym)|uniprotkb:rCG_48999(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Niizuma et al. (2008)	pubmed:18845684|doi:10.1073/pnas.0806222105|imex:IM-14341	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15732918|imex:IM-14341-2|dip:DIP-103272E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016707(gene)|ensembl:ENSRNOT00000022672(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0003407"(neural retina development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035702|reactome:R-RNO-168638|reactome:R-RNO-205025|reactome:R-RNO-6803207|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rgd:69274|refseq:NP_071967.2|dip:DIP-48602N	ensembl:ENSRNOG00000008507(gene)|ensembl:ENSRNOT00000063946(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0070513"(death domain binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR037939|interpro:IPR042148|reactome:R-RNO-6803207|rgd:1311010|refseq:NP_001101555.1|dip:DIP-48601N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:ZNIUFaw1pJ8CgILlXc7yNn0aOZA10116	rogid:ElyRtZyZyq2hMko/t9ztSzqcktM10116	rigid:6n+JFTGp8nOmxED2y3fQBVvuKUw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55215	uniprotkb:D3ZZY5	intact:EBI-15732853|ensembl:ENSRNOP00000022672|uniprotkb:O35398|uniprotkb:O55194|uniprotkb:Q9WUI6	intact:EBI-15732799|ensembl:ENSRNOP00000025291|ensembl:ENSRNOP00000065320	psi-mi:casp2_rat(display_long)|uniprotkb:Casp2(gene name)|psi-mi:Casp2(display_short)|uniprotkb:Ich1(gene name synonym)|uniprotkb:Protease ICH-1(gene name synonym)	psi-mi:d3zzy5_rat(display_long)|uniprotkb:Pidd1(gene name)|psi-mi:Pidd1(display_short)|uniprotkb:LOC100911519(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Niizuma et al. (2008)	pubmed:18845684|doi:10.1073/pnas.0806222105|imex:IM-14341	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15732918|imex:IM-14341-2|dip:DIP-103272E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016707(gene)|ensembl:ENSRNOT00000022672(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0003407"(neural retina development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035702|reactome:R-RNO-168638|reactome:R-RNO-205025|reactome:R-RNO-6803207|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rgd:69274|refseq:NP_071967.2|dip:DIP-48602N	ensembl:ENSRNOG00000018710(gene)|ensembl:ENSRNOG00000049179(gene)|ensembl:ENSRNOT00000025290(transcript)|ensembl:ENSRNOT00000072774(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011029(DEATH-like)|interpro:IPR019502|interpro:IPR032675|reactome:R-RNO-6803207|refseq:NP_001099788.2|refseq:XP_003749059.1|refseq:XP_008772966.1|rgd:1311792|rgd:6492303|dip:DIP-48600N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/06	2017/08/10	rogid:ZNIUFaw1pJ8CgILlXc7yNn0aOZA10116	rogid:R5H5gYEB5wSWw3DH0fn4r8TacS410116	rigid:6n+JFTGp8nOmxED2y3fQBVvuKUw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)