#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-16221250 uniprotkb:O16850 - intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1 psi-mi:hcf1(display_short)|psi-mi:EBI-16221250(display_long) psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2008) pubmed:18828672|doi:10.1371/journal.pbio.0060233|imex:IM-9609 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16221252|imex:IM-9609-1|dip:DIP-88303E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q18654(uniprot-removed-ac) refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638 psi-mi:"MI:0465"(dip) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/09 2017/08/10 - rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239 - false - green fluorescent protein tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-16221250 uniprotkb:O16850 - intact:EBI-324028|uniprotkb:O16849|uniprotkb:O18676|uniprotkb:Q86S42|intact:EBI-1770827|uniprotkb:F3NWW7|uniprotkb:F3NWX0|uniprotkb:G4RQR7|uniprotkb:G4S686|uniprotkb:G4SKG3|uniprotkb:G4SKH0|ensemblmetazoa:R13H8.1h.1 psi-mi:hcf1(display_short)|psi-mi:EBI-16221250(display_long) psi-mi:foxo_caeel(display_long)|uniprotkb:Abnormal dauer formation protein 16(gene name synonym)|uniprotkb:daf-16(gene name)|psi-mi:daf-16(display_short)|uniprotkb:R13H8.1(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2008) pubmed:18828672|doi:10.1371/journal.pbio.0060233|imex:IM-9609 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16221271|imex:IM-9609-2|dip:DIP-88303E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q18654(uniprot-removed-ac) refseq:NP_001021593.1|refseq:NP_001021594.1|refseq:NP_001021595.1|refseq:NP_001021597.1|wormbase:R13H8.1a|wormbase:R13H8.1b|wormbase:R13H8.1c|wormbase:R13H8.1e|refseq:NP_001021596.1|reactome:R-CEL-9607240|refseq:NP_001021598.2|refseq:NP_001251490.1|refseq:NP_001251492.1|reactome:R-CEL-9614399|reactome:R-CEL-9615017|reactome:R-CEL-9617629|wormbase:R13H8.1d|wormbase:R13H8.1f|wormbase:R13H8.1g|wormbase:R13H8.1h|ensemblmetazoa:R13H8.1h.1(transcript)|ensemblmetazoa:WBGene00000912(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002119"(nematode larval development)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0007614"(short-term memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009411"(response to UV)|go:"GO:0010286"(heat acclimation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040024"(dauer larval development)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060537"(muscle tissue development)|go:"GO:0061065"(regulation of dauer larval development)|go:"GO:0061066"(positive regulation of dauer larval development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1905909"(regulation of dauer entry)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|go:"GO:0045087"(innate immune response)|reactome:R-CEL-198693|reactome:R-CEL-211163|reactome:R-CEL-5687128|dip:DIP-25581N|reactome:R-CEL-5689880|reactome:R-CEL-1181150|reactome:R-CEL-9617828|reactome:R-CEL-9634638 psi-mi:"MI:0465"(dip) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2017/08/09 2017/08/10 - rogid:UfAMA8NPgcJv93n6XAjW5mLboZQ6239 - false - green fluorescent protein tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)