#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29350	uniprotkb:Q8NHL6	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989012|imex:IM-25798-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	-	-	-	figure legend:2A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2017/05/04	2017/05/25	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rigid:+5v8WtFw4yApfHzKxVvpFzl5nUk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29350	uniprotkb:O75022	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	intact:EBI-2830524|uniprotkb:Q86U49|uniprotkb:O15471|uniprotkb:C9JIP1|intact:EBI-3453813|uniprotkb:C9J1P3|ensembl:ENSP00000245620|ensembl:ENSP00000375630|ensembl:ENSP00000479234|ensembl:ENSP00000483625	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:lirb3_human(display_long)|uniprotkb:LILRB3(gene name)|psi-mi:LILRB3(display_short)|uniprotkb:ILT5(gene name synonym)|uniprotkb:LIR3(gene name synonym)|uniprotkb:CD85 antigen-like family member A(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HL9(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989096|imex:IM-25798-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	refseq:NP_001074919.2|refseq:XP_016885785.1|refseq:XP_016885786.1|refseq:XP_006726377.1|ensembl:ENSG00000204577(gene)|ensembl:ENSG00000274587(gene)|ensembl:ENSG00000275019(gene)|ensembl:ENST00000245620(transcript)|ensembl:ENST00000391750(transcript)|ensembl:ENST00000611086(transcript)|ensembl:ENST00000613698(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:2A-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2017/05/04	2017/05/25	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rogid:m/fh1ou36YQTaovYyLEi47WSy7Q9606	rigid:fIy3IDR1n6ko5OOtLHPhsnYn2Dg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29350	uniprotkb:Q8NHJ6	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	intact:EBI-2805248|uniprotkb:A8MVL8|uniprotkb:Q8N1C7|uniprotkb:O15468|uniprotkb:O75021|uniprotkb:Q6FGQ9|uniprotkb:Q8NHL5|ensembl:ENSP00000375616|ensembl:ENSP00000479829	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:lirb4_human(display_long)|uniprotkb:ILT3(gene name synonym)|uniprotkb:LIR5(gene name synonym)|uniprotkb:CD85 antigen-like family member K(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 3(gene name synonym)|uniprotkb:Leukocyte immunoglobulin-like receptor 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HM18(gene name synonym)|uniprotkb:LILRB4(gene name)|psi-mi:LILRB4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989128|imex:IM-25798-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	refseq:NP_001265355.2|refseq:NP_001265356.2|refseq:NP_001265357.2|refseq:NP_001265358.2|refseq:NP_001265359.2|ensembl:ENSG00000186818(gene)|ensembl:ENSG00000275730(gene)|ensembl:ENST00000391736(transcript)|ensembl:ENST00000612454(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002507"(tolerance induction)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045584"(negative regulation of cytotoxic T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:0098752"(integral component of the cytoplasmic side of the plasma membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000524"(negative regulation of T cell costimulation)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3P2T|rcsb pdb:6K7O|reactome:R-HSA-198933|interpro:IPR013151(Immunoglobulin)	-	-	-	figure legend:2A-9|comment:weak reaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-monocyte)|taxid:9606(Human mononuclear cells)	-	2017/05/04	2017/05/25	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rogid:GC8ymLbHSWFCosuiUOuJc4igRYM9606	rigid:GWs5pK/teZZG+opZ596RKkSB2N0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHL6	uniprotkb:P29350	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989065|imex:IM-25798-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-macrophage)|taxid:9606(Human macrophages)	-	2017/05/04	2017/05/25	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:+5v8WtFw4yApfHzKxVvpFzl5nUk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75022	uniprotkb:P29350	intact:EBI-2830524|uniprotkb:Q86U49|uniprotkb:O15471|uniprotkb:C9JIP1|intact:EBI-3453813|uniprotkb:C9J1P3|ensembl:ENSP00000245620|ensembl:ENSP00000375630|ensembl:ENSP00000479234|ensembl:ENSP00000483625	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb3_human(display_long)|uniprotkb:LILRB3(gene name)|psi-mi:LILRB3(display_short)|uniprotkb:ILT5(gene name synonym)|uniprotkb:LIR3(gene name synonym)|uniprotkb:CD85 antigen-like family member A(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HL9(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989100|imex:IM-25798-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074919.2|refseq:XP_016885785.1|refseq:XP_016885786.1|refseq:XP_006726377.1|ensembl:ENSG00000204577(gene)|ensembl:ENSG00000274587(gene)|ensembl:ENSG00000275019(gene)|ensembl:ENST00000245620(transcript)|ensembl:ENST00000391750(transcript)|ensembl:ENST00000611086(transcript)|ensembl:ENST00000613698(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-macrophage)|taxid:9606(Human macrophages)	-	2017/05/04	2017/05/25	rogid:m/fh1ou36YQTaovYyLEi47WSy7Q9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:fIy3IDR1n6ko5OOtLHPhsnYn2Dg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHJ6	uniprotkb:P29350	intact:EBI-2805248|uniprotkb:A8MVL8|uniprotkb:Q8N1C7|uniprotkb:O15468|uniprotkb:O75021|uniprotkb:Q6FGQ9|uniprotkb:Q8NHL5|ensembl:ENSP00000375616|ensembl:ENSP00000479829	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb4_human(display_long)|uniprotkb:ILT3(gene name synonym)|uniprotkb:LIR5(gene name synonym)|uniprotkb:CD85 antigen-like family member K(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 3(gene name synonym)|uniprotkb:Leukocyte immunoglobulin-like receptor 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HM18(gene name synonym)|uniprotkb:LILRB4(gene name)|psi-mi:LILRB4(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989133|imex:IM-25798-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265355.2|refseq:NP_001265356.2|refseq:NP_001265357.2|refseq:NP_001265358.2|refseq:NP_001265359.2|ensembl:ENSG00000186818(gene)|ensembl:ENSG00000275730(gene)|ensembl:ENST00000391736(transcript)|ensembl:ENST00000612454(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002507"(tolerance induction)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045584"(negative regulation of cytotoxic T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:0098752"(integral component of the cytoplasmic side of the plasma membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000524"(negative regulation of T cell costimulation)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3P2T|rcsb pdb:6K7O|reactome:R-HSA-198933|interpro:IPR013151(Immunoglobulin)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-macrophage)|taxid:9606(Human macrophages)	-	2017/05/04	2017/05/25	rogid:GC8ymLbHSWFCosuiUOuJc4igRYM9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:GWs5pK/teZZG+opZ596RKkSB2N0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N423	uniprotkb:P29350	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989147|imex:IM-25798-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-13|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-macrophage)|taxid:9606(Human macrophages)	-	2017/05/04	2017/05/25	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:5nG0hMKbq00WZ2MlESx1VGSCm/o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHL6	uniprotkb:P29350	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989078|imex:IM-25798-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:+5v8WtFw4yApfHzKxVvpFzl5nUk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75022	uniprotkb:P29350	intact:EBI-2830524|uniprotkb:Q86U49|uniprotkb:O15471|uniprotkb:C9JIP1|intact:EBI-3453813|uniprotkb:C9J1P3|ensembl:ENSP00000245620|ensembl:ENSP00000375630|ensembl:ENSP00000479234|ensembl:ENSP00000483625	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb3_human(display_long)|uniprotkb:LILRB3(gene name)|psi-mi:LILRB3(display_short)|uniprotkb:ILT5(gene name synonym)|uniprotkb:LIR3(gene name synonym)|uniprotkb:CD85 antigen-like family member A(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HL9(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989104|imex:IM-25798-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074919.2|refseq:XP_016885785.1|refseq:XP_016885786.1|refseq:XP_006726377.1|ensembl:ENSG00000204577(gene)|ensembl:ENSG00000274587(gene)|ensembl:ENSG00000275019(gene)|ensembl:ENST00000245620(transcript)|ensembl:ENST00000391750(transcript)|ensembl:ENST00000611086(transcript)|ensembl:ENST00000613698(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:m/fh1ou36YQTaovYyLEi47WSy7Q9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:fIy3IDR1n6ko5OOtLHPhsnYn2Dg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHJ6	uniprotkb:P29350	intact:EBI-2805248|uniprotkb:A8MVL8|uniprotkb:Q8N1C7|uniprotkb:O15468|uniprotkb:O75021|uniprotkb:Q6FGQ9|uniprotkb:Q8NHL5|ensembl:ENSP00000375616|ensembl:ENSP00000479829	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb4_human(display_long)|uniprotkb:ILT3(gene name synonym)|uniprotkb:LIR5(gene name synonym)|uniprotkb:CD85 antigen-like family member K(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 3(gene name synonym)|uniprotkb:Leukocyte immunoglobulin-like receptor 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HM18(gene name synonym)|uniprotkb:LILRB4(gene name)|psi-mi:LILRB4(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989137|imex:IM-25798-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265355.2|refseq:NP_001265356.2|refseq:NP_001265357.2|refseq:NP_001265358.2|refseq:NP_001265359.2|ensembl:ENSG00000186818(gene)|ensembl:ENSG00000275730(gene)|ensembl:ENST00000391736(transcript)|ensembl:ENST00000612454(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002507"(tolerance induction)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045584"(negative regulation of cytotoxic T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:0098752"(integral component of the cytoplasmic side of the plasma membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000524"(negative regulation of T cell costimulation)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3P2T|rcsb pdb:6K7O|reactome:R-HSA-198933|interpro:IPR013151(Immunoglobulin)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:GC8ymLbHSWFCosuiUOuJc4igRYM9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:GWs5pK/teZZG+opZ596RKkSB2N0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N423	uniprotkb:P29350	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989152|imex:IM-25798-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:5nG0hMKbq00WZ2MlESx1VGSCm/o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHL6	uniprotkb:P29350	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989091|imex:IM-25798-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:+5v8WtFw4yApfHzKxVvpFzl5nUk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75022	uniprotkb:P29350	intact:EBI-2830524|uniprotkb:Q86U49|uniprotkb:O15471|uniprotkb:C9JIP1|intact:EBI-3453813|uniprotkb:C9J1P3|ensembl:ENSP00000245620|ensembl:ENSP00000375630|ensembl:ENSP00000479234|ensembl:ENSP00000483625	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb3_human(display_long)|uniprotkb:LILRB3(gene name)|psi-mi:LILRB3(display_short)|uniprotkb:ILT5(gene name synonym)|uniprotkb:LIR3(gene name synonym)|uniprotkb:CD85 antigen-like family member A(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HL9(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989114|imex:IM-25798-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074919.2|refseq:XP_016885785.1|refseq:XP_016885786.1|refseq:XP_006726377.1|ensembl:ENSG00000204577(gene)|ensembl:ENSG00000274587(gene)|ensembl:ENSG00000275019(gene)|ensembl:ENST00000245620(transcript)|ensembl:ENST00000391750(transcript)|ensembl:ENST00000611086(transcript)|ensembl:ENST00000613698(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:m/fh1ou36YQTaovYyLEi47WSy7Q9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:fIy3IDR1n6ko5OOtLHPhsnYn2Dg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NHJ6	uniprotkb:P29350	intact:EBI-2805248|uniprotkb:A8MVL8|uniprotkb:Q8N1C7|uniprotkb:O15468|uniprotkb:O75021|uniprotkb:Q6FGQ9|uniprotkb:Q8NHL5|ensembl:ENSP00000375616|ensembl:ENSP00000479829	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb4_human(display_long)|uniprotkb:ILT3(gene name synonym)|uniprotkb:LIR5(gene name synonym)|uniprotkb:CD85 antigen-like family member K(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 3(gene name synonym)|uniprotkb:Leukocyte immunoglobulin-like receptor 5(gene name synonym)|uniprotkb:Monocyte inhibitory receptor HM18(gene name synonym)|uniprotkb:LILRB4(gene name)|psi-mi:LILRB4(display_short)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989141|imex:IM-25798-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001265355.2|refseq:NP_001265356.2|refseq:NP_001265357.2|refseq:NP_001265358.2|refseq:NP_001265359.2|ensembl:ENSG00000186818(gene)|ensembl:ENSG00000275730(gene)|ensembl:ENST00000391736(transcript)|ensembl:ENST00000612454(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002507"(tolerance induction)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030293"(transmembrane receptor protein tyrosine kinase inhibitor activity)|go:"GO:0030547"(signaling receptor inhibitor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045584"(negative regulation of cytotoxic T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:0098752"(integral component of the cytoplasmic side of the plasma membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:0150102"(negative regulation of monocyte activation)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000524"(negative regulation of T cell costimulation)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3P2T|rcsb pdb:6K7O|reactome:R-HSA-198933|interpro:IPR013151(Immunoglobulin)	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:GC8ymLbHSWFCosuiUOuJc4igRYM9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:GWs5pK/teZZG+opZ596RKkSB2N0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N423	uniprotkb:P29350	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-78260|intact:EBI-28977917|ensembl:ENSP00000326010|uniprotkb:Q969V8|uniprotkb:A8K306|uniprotkb:G3V0F8|uniprotkb:Q9UK67	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:ptn6_human(display_long)|uniprotkb:PTPN6(gene name)|psi-mi:PTPN6(display_short)|uniprotkb:HCP(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1C(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:SH-PTP1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase SHP-1(gene name synonym)|uniprotkb:PTP1C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mori et al. (2008)	pubmed:18802077|imex:IM-25798	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14989157|imex:IM-25798-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000111679(gene)|ensembl:ENST00000318974(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905867"(epididymis development)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P29350|rcsb pdb:1FPR|rcsb pdb:1GWZ|rcsb pdb:1X6C|rcsb pdb:2B3O|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:4GRY|rcsb pdb:4GRZ|rcsb pdb:4GS0|rcsb pdb:4HJP|rcsb pdb:4HJQ|rcsb pdb:6SM5|reactome:R-HSA-114604|reactome:R-HSA-1433559|reactome:R-HSA-210990|reactome:R-HSA-388841|reactome:R-HSA-389948|reactome:R-HSA-391160|reactome:R-HSA-432142|reactome:R-HSA-512988|reactome:R-HSA-5690714|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-877312|rcsb pdb:3PS5|reactome:R-HSA-9008059|reactome:R-HSA-909733|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-982772|reactome:R-HSA-983695|refseq:NP_002822.2|refseq:NP_536858.1|refseq:NP_536859.1|ensembl:ENSP00000326010|ensembl:ENST00000399448|ensembl:ENSP00000382376|ensembl:ENST00000456013|ensembl:ENSP00000391592|refseq:XP_011519290.1|dip:DIP-31002N	-	-	-	figure legend:2A-15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-osteoclast)|taxid:9606(Homo sapiens)	-	2017/05/04	2017/05/25	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:1o9Eaibzjx0irvkKKbwqq29wGts9606	rigid:5nG0hMKbq00WZ2MlESx1VGSCm/o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)