#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O76222 uniprotkb:Q57YZ3 intact:EBI-15729489 intact:EBI-15729534|uniprotkb:D6XL55 psi-mi:o76222_9tryp(display_long)|uniprotkb:PI3K(gene name)|psi-mi:PI3K(display_short) psi-mi:q57yz3_tryb2(display_long)|uniprotkb:Tb927.8.3200(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15729559|imex:IM-14331-1|dip:DIP-103251E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|dip:DIP-48592N go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|dip:DIP-48595N|refseq:XP_847151.1 psi-mi:"MI:0465"(dip) - crc64:9671512C9DDE1185 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:IXP8NuTxLITETGsUJIDEuc/SqmY5691 rogid:pLX6q3+ekmI3GsqPRhif3jcSOPM185431 rigid:JYX2pB9pvlsnEqbhIyUVLUJY6vM false - myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O76222 uniprotkb:Q387I9 intact:EBI-15729489 intact:EBI-15729510 psi-mi:o76222_9tryp(display_long)|uniprotkb:PI3K(gene name)|psi-mi:PI3K(display_short) psi-mi:q387i9_tryb2(display_long)|uniprotkb:Tb11.03.0460(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15729559|imex:IM-14331-1|dip:DIP-103251E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|dip:DIP-48592N go:"GO:0031931"(TORC1 complex)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|go:"GO:0031929"(TOR signaling)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|dip:DIP-48594N|refseq:XP_828154.1 psi-mi:"MI:0465"(dip) - crc64:12F8BAE200C761C9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:IXP8NuTxLITETGsUJIDEuc/SqmY5691 rogid:3mnE1nUm8wY9DVGFzGl2t8Lg3EU185431 rigid:JYX2pB9pvlsnEqbhIyUVLUJY6vM false - myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q57WF7 uniprotkb:Q57UT3 intact:EBI-15729610|uniprotkb:D6XIM3 intact:EBI-15729581|uniprotkb:D6XEX8 psi-mi:q57wf7_tryb2(display_long)|uniprotkb:Tb927.7.3420(orf name) psi-mi:q57ut3_tryb2(display_long)|uniprotkb:Tb927.4.420(orf name) psi-mi:"MI:0096"(pull down) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729624|imex:IM-14331-2|dip:DIP-103255E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005930"(axoneme)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|dip:DIP-48596N|refseq:XP_845965.1 go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903939"(regulation of TORC2 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR036738|interpro:IPR036940|dip:DIP-48593N|refseq:XP_844192.1 psi-mi:"MI:0465"(dip) crc64:D28EDAA77792E620 crc64:A3BCB24DC0FC8495 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:SAR/n0l7sBI6mdDPnOk/6e7D3Go185431 rogid:LvOT1O7dX27T7VaAlum5oaKv9PU185431 rigid:d2uEXfEuuGIZuUEus7rS+MWpyOA false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q57YZ3 uniprotkb:O76222 intact:EBI-15729534|uniprotkb:D6XL55 intact:EBI-15729489 psi-mi:q57yz3_tryb2(display_long)|uniprotkb:Tb927.8.3200(orf name) psi-mi:o76222_9tryp(display_long)|uniprotkb:PI3K(gene name)|psi-mi:PI3K(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15729679|imex:IM-14331-5|dip:DIP-103254E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|dip:DIP-48595N|refseq:XP_847151.1 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|dip:DIP-48592N psi-mi:"MI:0465"(dip) crc64:9671512C9DDE1185 - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:pLX6q3+ekmI3GsqPRhif3jcSOPM185431 rogid:IXP8NuTxLITETGsUJIDEuc/SqmY5691 rigid:IsS6OtcHr+q2AMjYcJJUKZ/Ralw false experimental feature:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q57YZ3 uniprotkb:Q57UT3 intact:EBI-15729534|uniprotkb:D6XL55 intact:EBI-15729581|uniprotkb:D6XEX8 psi-mi:q57yz3_tryb2(display_long)|uniprotkb:Tb927.8.3200(orf name) psi-mi:q57ut3_tryb2(display_long)|uniprotkb:Tb927.4.420(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15729679|imex:IM-14331-5|dip:DIP-103254E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|dip:DIP-48595N|refseq:XP_847151.1 go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903939"(regulation of TORC2 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR036738|interpro:IPR036940|dip:DIP-48593N|refseq:XP_844192.1 psi-mi:"MI:0465"(dip) crc64:9671512C9DDE1185 crc64:A3BCB24DC0FC8495 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:pLX6q3+ekmI3GsqPRhif3jcSOPM185431 rogid:LvOT1O7dX27T7VaAlum5oaKv9PU185431 rigid:IsS6OtcHr+q2AMjYcJJUKZ/Ralw false experimental feature:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q57WF7 uniprotkb:Q57UT3 intact:EBI-15729610|uniprotkb:D6XIM3 intact:EBI-15729581|uniprotkb:D6XEX8 psi-mi:q57wf7_tryb2(display_long)|uniprotkb:Tb927.7.3420(orf name) psi-mi:q57ut3_tryb2(display_long)|uniprotkb:Tb927.4.420(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729699|imex:IM-14331-6|dip:DIP-103255E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005930"(axoneme)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|dip:DIP-48596N|refseq:XP_845965.1 go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903939"(regulation of TORC2 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR036738|interpro:IPR036940|dip:DIP-48593N|refseq:XP_844192.1 psi-mi:"MI:0465"(dip) crc64:D28EDAA77792E620 crc64:A3BCB24DC0FC8495 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:SAR/n0l7sBI6mdDPnOk/6e7D3Go185431 rogid:LvOT1O7dX27T7VaAlum5oaKv9PU185431 rigid:d2uEXfEuuGIZuUEus7rS+MWpyOA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q57YZ3 uniprotkb:Q57UT3 intact:EBI-15729534|uniprotkb:D6XL55 intact:EBI-15729581|uniprotkb:D6XEX8 psi-mi:q57yz3_tryb2(display_long)|uniprotkb:Tb927.8.3200(orf name) psi-mi:q57ut3_tryb2(display_long)|uniprotkb:Tb927.4.420(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729716|imex:IM-14331-7|dip:DIP-103252E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|dip:DIP-48595N|refseq:XP_847151.1 go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903939"(regulation of TORC2 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR036738|interpro:IPR036940|dip:DIP-48593N|refseq:XP_844192.1 psi-mi:"MI:0465"(dip) crc64:9671512C9DDE1185 crc64:A3BCB24DC0FC8495 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:pLX6q3+ekmI3GsqPRhif3jcSOPM185431 rogid:LvOT1O7dX27T7VaAlum5oaKv9PU185431 rigid:8WfKQUwwg4WaUYlDlisyTEPhU9g false myc tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q57UT3 uniprotkb:Q57YZ3 intact:EBI-15729581|uniprotkb:D6XEX8 intact:EBI-15729534|uniprotkb:D6XL55 psi-mi:q57ut3_tryb2(display_long)|uniprotkb:Tb927.4.420(orf name) psi-mi:q57yz3_tryb2(display_long)|uniprotkb:Tb927.8.3200(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729660|imex:IM-14331-4|dip:DIP-103252E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903939"(regulation of TORC2 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR024585|interpro:IPR036738|interpro:IPR036940|dip:DIP-48593N|refseq:XP_844192.1 go:"GO:0031932"(TORC2 complex)|go:"GO:0038203"(TORC2 signaling)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028267|interpro:IPR028268|interpro:IPR029451|interpro:IPR029452|interpro:IPR029453|dip:DIP-48595N|refseq:XP_847151.1 psi-mi:"MI:0465"(dip) crc64:A3BCB24DC0FC8495 crc64:9671512C9DDE1185 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:LvOT1O7dX27T7VaAlum5oaKv9PU185431 rogid:pLX6q3+ekmI3GsqPRhif3jcSOPM185431 rigid:8WfKQUwwg4WaUYlDlisyTEPhU9g false - myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O76222 uniprotkb:Q387I9 intact:EBI-15729489 intact:EBI-15729510 psi-mi:o76222_9tryp(display_long)|uniprotkb:PI3K(gene name)|psi-mi:PI3K(display_short) psi-mi:q387i9_tryb2(display_long)|uniprotkb:Tb11.03.0460(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729643|imex:IM-14331-3|dip:DIP-103253E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|dip:DIP-48592N go:"GO:0031931"(TORC1 complex)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|go:"GO:0031929"(TOR signaling)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|dip:DIP-48594N|refseq:XP_828154.1 psi-mi:"MI:0465"(dip) - crc64:12F8BAE200C761C9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:IXP8NuTxLITETGsUJIDEuc/SqmY5691 rogid:3mnE1nUm8wY9DVGFzGl2t8Lg3EU185431 rigid:e+Yx5U5odcaDrGuMITXRHV20BLE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O76222 uniprotkb:Q387I9 intact:EBI-15729489 intact:EBI-15729510 psi-mi:o76222_9tryp(display_long)|uniprotkb:PI3K(gene name)|psi-mi:PI3K(display_short) psi-mi:q387i9_tryb2(display_long)|uniprotkb:Tb11.03.0460(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Barquilla et al. (2008) pubmed:18796613|doi:10.1073/pnas.0802668105|imex:IM-14331 taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) taxid:185431(tryb2)|taxid:185431("Trypanosoma brucei brucei (strain 927/4 GUTat10.1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15729735|imex:IM-14331-8|dip:DIP-103253E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016773"(phosphotransferase activity, alcohol group as acceptor)|go:"GO:0031931"(TORC1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR009076(FKBP12-rapamycin-associated protein, FKBP12-rapamycin-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR026683|interpro:IPR036738|interpro:IPR036940|dip:DIP-48592N go:"GO:0031931"(TORC1 complex)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1903432"(regulation of TORC1 signaling)|interpro:IPR004083(Regulatory associated protein of TOR)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029347|interpro:IPR036322|go:"GO:0031929"(TOR signaling)|go:"GO:0005737"(cytoplasm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|dip:DIP-48594N|refseq:XP_828154.1 psi-mi:"MI:0465"(dip) - crc64:12F8BAE200C761C9 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:5691(9tryp)|taxid:5691(Trypanosoma brucei) - 2017/08/06 2017/08/10 rogid:IXP8NuTxLITETGsUJIDEuc/SqmY5691 rogid:3mnE1nUm8wY9DVGFzGl2t8Lg3EU185431 rigid:e+Yx5U5odcaDrGuMITXRHV20BLE false - myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)