#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13976	uniprotkb:Q14643	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726455|imex:IM-9522-2|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13976	uniprotkb:O76074	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726455|imex:IM-9522-2|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13976	uniprotkb:O76074	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726491|imex:IM-9522-1|dip:DIP-88217E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rigid:w9xF8U+CsK27FH8HFjU79RhYIsw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14643	uniprotkb:Q13976	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726508|imex:IM-9522-4|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14643	uniprotkb:O76074	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726508|imex:IM-9522-4|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O76074	uniprotkb:Q13976	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726473|imex:IM-9522-3|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O76074	uniprotkb:Q14643	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726473|imex:IM-9522-3|dip:DIP-88216E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rigid:/grzGo2ZAZA8mdF1DJmaJNUq2aQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13976	uniprotkb:O76074	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-9023531|uniprotkb:O75887|uniprotkb:O75026|uniprotkb:Q86V66|uniprotkb:A0AV69|uniprotkb:Q9Y6Z6|uniprotkb:A8K2C4|uniprotkb:Q86UI0|ensembl:ENSP00000347046	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:pde5a_human(display_long)|uniprotkb:PDE5A(gene name)|psi-mi:PDE5A(display_short)|uniprotkb:PDE5(gene name synonym)|uniprotkb:cGMP-binding cGMP-specific phosphodiesterase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2008)	pubmed:18757735|doi:10.1073/pnas.0804738105|imex:IM-9522	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15726526|imex:IM-9522-5|dip:DIP-88217E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N	refseq:NP_001074.2|refseq:NP_236914.2|refseq:NP_246273.2|dip:DIP-46287N|ensembl:ENSG00000138735(gene)|ensembl:ENST00000354960(transcript)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0030553"(cGMP binding)|go:"GO:0046069"(cGMP catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047555"(3',5'-cyclic-GMP phosphodiesterase activity)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003018(GAF)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR023174|interpro:IPR029016|interpro:IPR036971|rcsb pdb:1RKP|rcsb pdb:1T9R|rcsb pdb:1T9S|rcsb pdb:1TBF|rcsb pdb:1UDT|rcsb pdb:1UDU|rcsb pdb:1UHO|rcsb pdb:1XOZ|rcsb pdb:1XP0|rcsb pdb:2CHM|rcsb pdb:2H40|rcsb pdb:2H42|rcsb pdb:2H44|rcsb pdb:2XSS|rcsb pdb:3B2R|rcsb pdb:3BJC|rcsb pdb:3HC8|rcsb pdb:3HDZ|rcsb pdb:3JWQ|rcsb pdb:3JWR|rcsb pdb:3LFV|rcsb pdb:3MF0|rcsb pdb:3SHY|rcsb pdb:3SHZ|rcsb pdb:3SIE|rcsb pdb:3TGE|rcsb pdb:3TGG|rcsb pdb:4G2W|rcsb pdb:4G2Y|rcsb pdb:4I9Z|rcsb pdb:4IA0|rcsb pdb:4MD6|rcsb pdb:4OEW|rcsb pdb:5JO3|rcsb pdb:5ZZ2|rcsb pdb:6ACB|rcsb pdb:6IWI|rcsb pdb:6L6E|rcsb pdb:6VBI|reactome:R-HSA-418457|reactome:R-HSA-9013422|rcsb pdb:4OEX	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:a6slsG3AWgf0Zwz4Zq3ODQEC96M9606	rigid:w9xF8U+CsK27FH8HFjU79RhYIsw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)