#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P9WGH9 uniprotkb:P9WHW5 intact:EBI-15725907|uniprotkb:L0TEP5|uniprotkb:O05843|uniprotkb:P66807 intact:EBI-15725875|uniprotkb:L0T2B3|uniprotkb:P71588|uniprotkb:Q8VKT2 psi-mi:sigh_myctu(display_long)|uniprotkb:sigH(gene name)|psi-mi:sigH(display_short)|uniprotkb:Alternative RNA polymerase sigma factor SigH(gene name synonym)|uniprotkb:RNA polymerase sigma-H factor(gene name synonym)|uniprotkb:rpoE(gene name synonym)|uniprotkb:MTCY07D11.03(orf name)|uniprotkb:Rv3223c(locus name) psi-mi:pstp_myctu(display_long)|uniprotkb:pstP(gene name)|psi-mi:pstP(display_short)|uniprotkb:Mycobacterial Ser/Thr phosphatase(gene name synonym)|uniprotkb:mstp(gene name synonym)|uniprotkb:ppp(gene name synonym)|uniprotkb:Rv0018c(locus name)|uniprotkb:PP2C-family Ser/Thr phosphatase(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Park et al. (2008) pubmed:18728196|doi:10.1073/pnas.0801143105|imex:IM-9518 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15725941|imex:IM-9518-1|dip:DIP-88211E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5ZX2|go:"GO:0003677"(DNA binding)|go:"GO:0005618"(cell wall)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0016987"(sigma factor activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0006352"(DNA-templated transcription, initiation)|rcsb pdb:5ZX3|rcsb pdb:6JCX|rcsb pdb:6JCY|interpro:IPR000838(RNA polymerase sigma factor 70, ECF, conserved site)|interpro:IPR007627(RNA polymerase sigma-70 region 2)|interpro:IPR013249(RNA polymerase sigma factor 70, region 4 type 2)|interpro:IPR013324(RNA polymerase sigma factor, regions 3 and 4)|interpro:IPR013325(RNA polymerase sigma factor, region 2)|interpro:IPR014284(RNA polymerase sigma-70)|interpro:IPR014293(RNA polymerase sigma-70, actinobacteria)|refseq:NP_217739.1|refseq:WP_003416897.1|interpro:IPR036388|rcsb pdb:6KON|rcsb pdb:6KOO|rcsb pdb:6KOP|rcsb pdb:6KOQ|interpro:IPR039425 go:"GO:0004647"|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005618"(cell wall)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|rcsb pdb:1TXO|rcsb pdb:2CM1|refseq:NP_214532.1|refseq:WP_010886062.1|interpro:IPR036457 psi-mi:"MI:0465"(dip) crc64:AC0C33B47DB40CFD crc64:DD78F54D2FC19D95 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:j9dWKyEeniWrDs4wOzoO9ItBrkI83332 rogid:p6+bHuKiZxW0ehFkUS6UG4IFr2s83332 rigid:WSyW6sCRDo/F7G/HzvmTi+KzM4c false mutation disrupting interaction:26-26,106-106 - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P9WJ69 uniprotkb:P9WHW5 intact:EBI-15725962|uniprotkb:F2GK95|uniprotkb:Q6MWZ6|uniprotkb:Q8VJ46 intact:EBI-15725875|uniprotkb:L0T2B3|uniprotkb:P71588|uniprotkb:Q8VKT2 psi-mi:rsha_myctu(display_long)|uniprotkb:rshA(gene name)|psi-mi:rshA(display_short)|uniprotkb:Regulator of SigH(gene name synonym)|uniprotkb:Sigma-H anti-sigma factor RshA(gene name synonym)|uniprotkb:Rv3221A(locus name) psi-mi:pstp_myctu(display_long)|uniprotkb:pstP(gene name)|psi-mi:pstP(display_short)|uniprotkb:Mycobacterial Ser/Thr phosphatase(gene name synonym)|uniprotkb:mstp(gene name synonym)|uniprotkb:ppp(gene name synonym)|uniprotkb:Rv0018c(locus name)|uniprotkb:PP2C-family Ser/Thr phosphatase(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Park et al. (2008) pubmed:18728196|doi:10.1073/pnas.0801143105|imex:IM-9518 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15725985|imex:IM-9518-3|dip:DIP-88212E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR014295(Anti-sigma factor RshA)|interpro:IPR024020|interpro:IPR027383|refseq:WP_003416891.1|refseq:YP_177945.1 go:"GO:0004647"|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005618"(cell wall)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|rcsb pdb:1TXO|rcsb pdb:2CM1|refseq:NP_214532.1|refseq:WP_010886062.1|interpro:IPR036457 psi-mi:"MI:0465"(dip) crc64:36636191A0D86341 crc64:DD78F54D2FC19D95 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:ntu4RyKlGd3xMPn/3YyI4RZcddg83332 rogid:p6+bHuKiZxW0ehFkUS6UG4IFr2s83332 rigid:WR7kPMrQP1ySwaqQi7oPM7zPtnY false mutation disrupting interaction:94-94 - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P9WGH9 uniprotkb:P9WJ69 intact:EBI-15725907|uniprotkb:L0TEP5|uniprotkb:O05843|uniprotkb:P66807 intact:EBI-15725962|uniprotkb:F2GK95|uniprotkb:Q6MWZ6|uniprotkb:Q8VJ46 psi-mi:sigh_myctu(display_long)|uniprotkb:sigH(gene name)|psi-mi:sigH(display_short)|uniprotkb:Alternative RNA polymerase sigma factor SigH(gene name synonym)|uniprotkb:RNA polymerase sigma-H factor(gene name synonym)|uniprotkb:rpoE(gene name synonym)|uniprotkb:MTCY07D11.03(orf name)|uniprotkb:Rv3223c(locus name) psi-mi:rsha_myctu(display_long)|uniprotkb:rshA(gene name)|psi-mi:rshA(display_short)|uniprotkb:Regulator of SigH(gene name synonym)|uniprotkb:Sigma-H anti-sigma factor RshA(gene name synonym)|uniprotkb:Rv3221A(locus name) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Park et al. (2008) pubmed:18728196|doi:10.1073/pnas.0801143105|imex:IM-9518 taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") taxid:83332(myctu)|taxid:83332("Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15726005|imex:IM-9518-2|dip:DIP-88213E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:5ZX2|go:"GO:0003677"(DNA binding)|go:"GO:0005618"(cell wall)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0016987"(sigma factor activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0006352"(DNA-templated transcription, initiation)|rcsb pdb:5ZX3|rcsb pdb:6JCX|rcsb pdb:6JCY|interpro:IPR000838(RNA polymerase sigma factor 70, ECF, conserved site)|interpro:IPR007627(RNA polymerase sigma-70 region 2)|interpro:IPR013249(RNA polymerase sigma factor 70, region 4 type 2)|interpro:IPR013324(RNA polymerase sigma factor, regions 3 and 4)|interpro:IPR013325(RNA polymerase sigma factor, region 2)|interpro:IPR014284(RNA polymerase sigma-70)|interpro:IPR014293(RNA polymerase sigma-70, actinobacteria)|refseq:NP_217739.1|refseq:WP_003416897.1|interpro:IPR036388|rcsb pdb:6KON|rcsb pdb:6KOO|rcsb pdb:6KOP|rcsb pdb:6KOQ|interpro:IPR039425 go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR014295(Anti-sigma factor RshA)|interpro:IPR024020|interpro:IPR027383|refseq:WP_003416891.1|refseq:YP_177945.1 psi-mi:"MI:0465"(dip) crc64:AC0C33B47DB40CFD crc64:36636191A0D86341 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2017/08/10 rogid:j9dWKyEeniWrDs4wOzoO9ItBrkI83332 rogid:ntu4RyKlGd3xMPn/3YyI4RZcddg83332 rigid:1IXW3ewipGaa7KdnVCsarvJ+11k false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)