#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P55212	uniprotkb:P42574	intact:EBI-718729|uniprotkb:Q9BQE7|ensembl:ENSP00000265164	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:casp6_human(display_long)|uniprotkb:Apoptotic protease Mch-2(gene name synonym)|uniprotkb:CASP6(gene name)|psi-mi:CASP6(display_short)|uniprotkb:MCH2(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724506|imex:IM-14303-1|dip:DIP-103149E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001217.2|refseq:NP_116787.1|rcsb pdb:3K7E|rcsb pdb:3NKF|rcsb pdb:3NR2|rcsb pdb:3OD5|rcsb pdb:3P45|rcsb pdb:3P4U|rcsb pdb:3QNW|rcsb pdb:3S70|rcsb pdb:3S8E|rcsb pdb:3V6L|rcsb pdb:3V6M|rcsb pdb:4EJF|rcsb pdb:4FXO|rcsb pdb:4HVA|rcsb pdb:4IYR|rcsb pdb:4N5D|rcsb pdb:4N6G|rcsb pdb:4N7J|rcsb pdb:4N7M|rcsb pdb:4NBK|rcsb pdb:4NBL|rcsb pdb:4NBN|rcsb pdb:6DEU|rcsb pdb:6DEV|reactome:R-HSA-111465|reactome:R-HSA-264870|reactome:R-HSA-352238|reactome:R-HSA-6803207|ensembl:ENSG00000138794(gene)|ensembl:ENST00000265164(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR037554|mint:P55212|rcsb pdb:1MI9|rcsb pdb:2WDP|dip:DIP-44649N	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:x335dTT6omZBrEGs7jzxOjUWaNM9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:TnxJpUAIUSD+iTMqZMArD9Nnm84	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15185	uniprotkb:P55210	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724540|imex:IM-14303-3|dip:DIP-103156E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/06	2017/08/10	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:1XGOEv5N6IvcbbMuQKmqtDRNT/4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55211	uniprotkb:P55210	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724523|imex:IM-14303-2|dip:DIP-103151E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:f6VlpE3sPKZXTfqMi7SU6c/uMHw	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
intact:EBI-15724557	uniprotkb:P42574	dip:DIP-48548N	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:devd(display_short)|psi-mi:EBI-15724557(display_long)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724560|imex:IM-14303-4|dip:DIP-103157E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:96sTahW/dgnu1xJicqDs5nE4AHw-2	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:+55xpakztKjkLwvZDwpeSC487RY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P55212	uniprotkb:P55210	intact:EBI-718729|uniprotkb:Q9BQE7|ensembl:ENSP00000265164	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:casp6_human(display_long)|uniprotkb:Apoptotic protease Mch-2(gene name synonym)|uniprotkb:CASP6(gene name)|psi-mi:CASP6(display_short)|uniprotkb:MCH2(gene name synonym)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724577|imex:IM-14303-5|dip:DIP-103150E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001217.2|refseq:NP_116787.1|rcsb pdb:3K7E|rcsb pdb:3NKF|rcsb pdb:3NR2|rcsb pdb:3OD5|rcsb pdb:3P45|rcsb pdb:3P4U|rcsb pdb:3QNW|rcsb pdb:3S70|rcsb pdb:3S8E|rcsb pdb:3V6L|rcsb pdb:3V6M|rcsb pdb:4EJF|rcsb pdb:4FXO|rcsb pdb:4HVA|rcsb pdb:4IYR|rcsb pdb:4N5D|rcsb pdb:4N6G|rcsb pdb:4N7J|rcsb pdb:4N7M|rcsb pdb:4NBK|rcsb pdb:4NBL|rcsb pdb:4NBN|rcsb pdb:6DEU|rcsb pdb:6DEV|reactome:R-HSA-111465|reactome:R-HSA-264870|reactome:R-HSA-352238|reactome:R-HSA-6803207|ensembl:ENSG00000138794(gene)|ensembl:ENST00000265164(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR037554|mint:P55212|rcsb pdb:1MI9|rcsb pdb:2WDP|dip:DIP-44649N	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:x335dTT6omZBrEGs7jzxOjUWaNM9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:WhQ/MgAiQrKOZqvgsUc0ZAgxA5Y	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P52566	uniprotkb:P55210	intact:EBI-2806617|uniprotkb:B5BU79|ensembl:ENSP00000228945|ensembl:ENSP00000440560|ensembl:ENSP00000444860	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:gdir2_human(display_long)|uniprotkb:GDIA2(gene name synonym)|uniprotkb:GDID4(gene name synonym)|uniprotkb:RAP1GN1(gene name synonym)|uniprotkb:Ly-GDI(gene name synonym)|uniprotkb:Rho-GDI beta(gene name synonym)|uniprotkb:ARHGDIB(gene name)|psi-mi:ARHGDIB(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724594|imex:IM-14303-6|dip:DIP-103154E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166.3|ensembl:ENSG00000111348(gene)|ensembl:ENST00000541546(transcript)|ensembl:ENST00000541644(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071461"(cellular response to redox state)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|ensembl:ENST00000228945(transcript)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:P52566|rcsb pdb:1DS6|rcsb pdb:5H1D|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013423|refseq:NP_001308349.1|refseq:NP_001308350.1|refseq:NP_001308351.1|refseq:NP_001308352.1|dip:DIP-40959N	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:uiFgGyiT2vBDU0XIRX2ix/bDmHw9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rigid:HttqSEg/xfvbXhp/HeYmRE2InMQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-15724611	uniprotkb:P42574	dip:DIP-48549N	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:lehd(display_short)|psi-mi:EBI-15724611(display_long)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724614|imex:IM-14303-7|dip:DIP-103159E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:Mxy6EBsahcljolxfl+WKjqDT5ho-2	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:wUxnwKeKlIZl4kqGeSR/30o0UnI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42574	uniprotkb:P55957	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	intact:EBI-519672|uniprotkb:Q549M7|uniprotkb:Q71T04|uniprotkb:Q7Z4M9|ensembl:ENSP00000449236|ensembl:ENSP00000480414|uniprotkb:Q8IY86	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:bid_human(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:BID(gene name)|psi-mi:BID(display_short)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724631|imex:IM-14303-8|dip:DIP-103152E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	ensembl:ENSG00000015475(gene)|ensembl:ENST00000551952(transcript)|ensembl:ENST00000622694(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P55957|rcsb pdb:1ZY3|rcsb pdb:2BID|rcsb pdb:2KBW|rcsb pdb:2M5B|rcsb pdb:2M5I|rcsb pdb:4BD2|rcsb pdb:4QVE|rcsb pdb:4ZEQ|rcsb pdb:4ZIG|rcsb pdb:4ZII|rcsb pdb:5AJJ|rcsb pdb:5C3F|reactome:R-HSA-111447|reactome:R-HSA-111452|reactome:R-HSA-111453|reactome:R-HSA-114294|reactome:R-HSA-6803204|reactome:R-HSA-75108|go:"GO:0005123"(death receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|refseq:NP_001187.1|refseq:NP_932070.1|refseq:NP_001231498.1|refseq:NP_001231499.1|refseq:NP_001231501.1|refseq:NP_932071.1|refseq:NP_001231496.1|dip:DIP-34937N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rogid:K7148hFL21ctiVuJRKEsddUE3tc9606	rigid:PDxzIpyV4jgbzX1rrVyAeYngHXg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52566	uniprotkb:P42574	intact:EBI-2806617|uniprotkb:B5BU79|ensembl:ENSP00000228945|ensembl:ENSP00000440560|ensembl:ENSP00000444860	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:gdir2_human(display_long)|uniprotkb:GDIA2(gene name synonym)|uniprotkb:GDID4(gene name synonym)|uniprotkb:RAP1GN1(gene name synonym)|uniprotkb:Ly-GDI(gene name synonym)|uniprotkb:Rho-GDI beta(gene name synonym)|uniprotkb:ARHGDIB(gene name)|psi-mi:ARHGDIB(display_short)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724682|imex:IM-14303-11|dip:DIP-103153E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001166.3|ensembl:ENSG00000111348(gene)|ensembl:ENST00000541546(transcript)|ensembl:ENST00000541644(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071461"(cellular response to redox state)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|ensembl:ENST00000228945(transcript)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:P52566|rcsb pdb:1DS6|rcsb pdb:5H1D|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013423|refseq:NP_001308349.1|refseq:NP_001308350.1|refseq:NP_001308351.1|refseq:NP_001308352.1|dip:DIP-40959N	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:uiFgGyiT2vBDU0XIRX2ix/bDmHw9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:bKB3nZQEwLKrc3aadCTufY/OVi0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55211	uniprotkb:P42574	intact:EBI-516799|uniprotkb:O95348|uniprotkb:Q92852|uniprotkb:Q9BQ62|uniprotkb:Q9UEQ3|uniprotkb:Q9UIJ8|uniprotkb:Q53Y70|uniprotkb:Q5JRU9|uniprotkb:Q5UGI1|uniprotkb:B4E1A3|ensembl:ENSP00000330237	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:casp9_human(display_long)|uniprotkb:ICE-like apoptotic protease 6(gene name synonym)|uniprotkb:Apoptotic protease Mch-6(gene name synonym)|uniprotkb:Apoptotic protease-activating factor 3(gene name synonym)|uniprotkb:CASP9(gene name)|psi-mi:CASP9(display_short)|uniprotkb:MCH6(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724665|imex:IM-14303-10|dip:DIP-71646E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264983.1|refseq:NP_001220.2|refseq:NP_127463.2|refseq:XP_005246071.1|dip:DIP-27625N|ensembl:ENSG00000132906(gene)|ensembl:ENST00000333868(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007568"(aging)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030220"(platelet formation)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033171|interpro:IPR042147|mint:P55211|rcsb pdb:1JXQ|rcsb pdb:1NW9|rcsb pdb:2AR9|rcsb pdb:3D9T|rcsb pdb:3V3K|rcsb pdb:3YGS|rcsb pdb:4RHW|rcsb pdb:5JUY|rcsb pdb:5WVC|rcsb pdb:5WVE|reactome:R-HSA-111458|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-168638|reactome:R-HSA-198323|reactome:R-HSA-418889|reactome:R-HSA-5674400|reactome:R-HSA-9627069	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:IYW59Vh17AEnXa6/wLpkIPNE0Bo9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:DkgBPRbV783KTvHhhoBS9yoLclA	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q15185	uniprotkb:P42574	intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym)	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724648|imex:IM-14303-9|dip:DIP-103155E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rigid:+OKv9KtWm+gebKzP04wlvcRgWvE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55210	intact:EBI-15724557	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	dip:DIP-48548N	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:devd(display_short)|psi-mi:EBI-15724557(display_long)	psi-mi:"MI:0435"(protease assay)	Walsh et al. (2008)	pubmed:18723680|doi:10.1073/pnas.0707715105|imex:IM-14303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15724699|imex:IM-14303-12|dip:DIP-103158E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:96sTahW/dgnu1xJicqDs5nE4AHw-2	rigid:uwMNz5AA8x4/nvTY8e/FXqab7/g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)