#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08120	uniprotkb:P54631	intact:EBI-109669|uniprotkb:A4V070|uniprotkb:Q9VMV4|ensemblmetazoa:FBpp0078640|ensemblmetazoa:FBpp0078641|ensemblmetazoa:FBpp0078642	intact:EBI-118117|uniprotkb:Q8INV8|ensemblmetazoa:FBpp0080802|ensemblmetazoa:FBpp0310402	psi-mi:co4a1_drome(display_long)|uniprotkb:Cg25C(gene name synonym)|uniprotkb:Collagen type IV alpha 1(gene name synonym)|uniprotkb:DCg1(gene name synonym)|uniprotkb:CG4145(orf name)|uniprotkb:Col4a1(gene name)|psi-mi:Col4a1(display_short)	psi-mi:scw_drome(display_long)|uniprotkb:scw(gene name)|psi-mi:scw(display_short)|uniprotkb:CG31695(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721756|imex:IM-17969-1|dip:DIP-189531E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_723044.1|refseq:NP_723045.1|refseq:NP_723046.1|flybase:FBgn0000299|dip:DIP-59819N|ensemblmetazoa:FBgn0000299(gene)|ensemblmetazoa:FBtr0079001(transcript)|ensemblmetazoa:FBtr0079002(transcript)|ensemblmetazoa:FBtr0079003(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007391"(dorsal closure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035848"(oviduct morphogenesis)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048621"(post-embryonic digestive tract morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954	refseq:NP_524863.3|flybase:FBgn0005590|ensemblmetazoa:FBgn0005590(gene)|ensemblmetazoa:FBtr0081261(transcript)|ensemblmetazoa:FBtr0343860(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007502"(digestive tract mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008406"(gonad development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-2129379|reactome:R-DME-2173789|reactome:R-DME-2173791|reactome:R-DME-3000170|reactome:R-DME-381426|reactome:R-DME-8941855|reactome:R-DME-8941858|reactome:R-DME-8951936|reactome:R-DME-8957275|go:"GO:0048018"(receptor ligand activity)|refseq:NP_001286088.1|dip:DIP-59820N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:pmVLw1fJsIe0Zm4vtQN3gdv/EB87227	rogid:VifIwMWiUB+/kdW9WIzvSzggc9w7227	rigid:0SUoUbk8mEAYuqeG1BGt+UdDLrE	false	sufficient binding region:1546-1779|glutathione s tranferase tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08120	uniprotkb:P07713	intact:EBI-109669|uniprotkb:A4V070|uniprotkb:Q9VMV4|ensemblmetazoa:FBpp0078640|ensemblmetazoa:FBpp0078641|ensemblmetazoa:FBpp0078642	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:co4a1_drome(display_long)|uniprotkb:Cg25C(gene name synonym)|uniprotkb:Collagen type IV alpha 1(gene name synonym)|uniprotkb:DCg1(gene name synonym)|uniprotkb:CG4145(orf name)|uniprotkb:Col4a1(gene name)|psi-mi:Col4a1(display_short)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721756|imex:IM-17969-1|dip:DIP-189531E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_723044.1|refseq:NP_723045.1|refseq:NP_723046.1|flybase:FBgn0000299|dip:DIP-59819N|ensemblmetazoa:FBgn0000299(gene)|ensemblmetazoa:FBtr0079001(transcript)|ensemblmetazoa:FBtr0079002(transcript)|ensemblmetazoa:FBtr0079003(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007391"(dorsal closure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035848"(oviduct morphogenesis)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048621"(post-embryonic digestive tract morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:pmVLw1fJsIe0Zm4vtQN3gdv/EB87227	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:0SUoUbk8mEAYuqeG1BGt+UdDLrE	false	sufficient binding region:1546-1779|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P07713	uniprotkb:O18407	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	intact:EBI-15721782	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721877|imex:IM-17969-4|dip:DIP-189528E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rigid:ohElg8dhHC8lHIUOmHIf7Gnc0TU	false	-	binding-associated region:1505-1761|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q24025	uniprotkb:O18407	intact:EBI-184947|uniprotkb:Q9VXS7|uniprotkb:B7FNI9|ensemblmetazoa:FBpp0073879|ensemblmetazoa:FBpp0304148|ensemblmetazoa:FBpp0309304	intact:EBI-15721782	psi-mi:sog_drome(display_long)|uniprotkb:sog(gene name)|psi-mi:sog(display_short)|uniprotkb:CG9224(orf name)|uniprotkb:Short gastrulation protein(gene name synonym)	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721854|imex:IM-17969-3|dip:DIP-189532E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476736.1|flybase:FBgn0003463|refseq:NP_001259576.1|refseq:NP_001259578.1|dip:DIP-20760N|ensemblmetazoa:FBgn0003463(gene)|ensemblmetazoa:FBtr0074063(transcript)|ensemblmetazoa:FBtr0331760(transcript)|ensemblmetazoa:FBtr0340346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0035271"(ring gland development)|go:"GO:0035592"(establishment of protein localization to extracellular region)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0061328"(posterior Malpighian tubule development)|go:"GO:0110107"(regulation of imaginal disc-derived wing vein specification)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:KC34gvwDW/5LKdgJ3UpuOFZiZUg7227	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rigid:zY0aRX7tKYPyMo/J2YfX865/Bg4	false	myc tag:c-c	binding-associated region:1505-1761|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P07713	uniprotkb:O18407	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	intact:EBI-15721782	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721812|imex:IM-17969-2|dip:DIP-189528E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rigid:ohElg8dhHC8lHIUOmHIf7Gnc0TU	false	ha tag:c-c	sufficient binding region:1618-1622|glutathione s tranferase tag:n-n|mutation disrupting interaction:1620-1620,1612-1612|mutation disrupting interaction:1615-1615,1614-1614,1613-1613,1612-1612|mutation disrupting interaction:1620-1620,1618-1618,1617-1617,1615-1615,1614-1614,1613-1613,1612-1612	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P07713	uniprotkb:O18407	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	intact:EBI-15721782	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721969|imex:IM-17969-8|dip:DIP-189528E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/06	2017/08/10	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rigid:ohElg8dhHC8lHIUOmHIf7Gnc0TU	false	ha tag:c-c	sufficient binding region:1618-1622|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P36895	uniprotkb:P07713	intact:EBI-2551936|ensembl:ENSMUSP00000035900	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:bmr1a_mouse(display_long)|uniprotkb:Bmpr1a(gene name)|psi-mi:Bmpr1a(display_short)|uniprotkb:Acvrlk3(gene name synonym)|uniprotkb:Bmpr(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)|uniprotkb:BMP-2/BMP-4 receptor(gene name synonym)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721950|imex:IM-17969-7|dip:DIP-189534E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-201451|go:"GO:0098821"(BMP receptor activity)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060896"(neural plate pattern specification)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0036122"(BMP binding)|ensembl:ENSMUSG00000021796(gene)|ensembl:ENSMUST00000049005(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007389"(pattern specification process)|go:"GO:0007398"(ectoderm development)|go:"GO:0007399"(nervous system development)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|refseq:NP_033888.2|refseq:XP_017171295.1|refseq:XP_006518532.1|refseq:XP_006518533.1|dip:DIP-5796N	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:CTt0LKWLVZBtUhV9L7Ma1iD/Phk10090	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:WsX9SkqG8II1iQVUbh+7aa9TInI	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O18407	uniprotkb:P54631	intact:EBI-15721782	intact:EBI-118117|uniprotkb:Q8INV8|ensemblmetazoa:FBpp0080802|ensemblmetazoa:FBpp0310402	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:scw_drome(display_long)|uniprotkb:scw(gene name)|psi-mi:scw(display_short)|uniprotkb:CG31695(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721924|imex:IM-17969-6|dip:DIP-189530E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	refseq:NP_524863.3|flybase:FBgn0005590|ensemblmetazoa:FBgn0005590(gene)|ensemblmetazoa:FBtr0081261(transcript)|ensemblmetazoa:FBtr0343860(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007502"(digestive tract mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008406"(gonad development)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-2129379|reactome:R-DME-2173789|reactome:R-DME-2173791|reactome:R-DME-3000170|reactome:R-DME-381426|reactome:R-DME-8941855|reactome:R-DME-8941858|reactome:R-DME-8951936|reactome:R-DME-8957275|go:"GO:0048018"(receptor ligand activity)|refseq:NP_001286088.1|dip:DIP-59820N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rogid:VifIwMWiUB+/kdW9WIzvSzggc9w7227	rigid:yuJW94PsoQpQ1feG9cxO7IU9I70	false	sufficient binding region:1505-1761|glutathione s tranferase tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O18407	uniprotkb:P07713	intact:EBI-15721782	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721924|imex:IM-17969-6|dip:DIP-189530E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:yuJW94PsoQpQ1feG9cxO7IU9I70	false	sufficient binding region:1505-1761|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08120	uniprotkb:P07713	intact:EBI-109669|uniprotkb:A4V070|uniprotkb:Q9VMV4|ensemblmetazoa:FBpp0078640|ensemblmetazoa:FBpp0078641|ensemblmetazoa:FBpp0078642	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:co4a1_drome(display_long)|uniprotkb:Cg25C(gene name synonym)|uniprotkb:Collagen type IV alpha 1(gene name synonym)|uniprotkb:DCg1(gene name synonym)|uniprotkb:CG4145(orf name)|uniprotkb:Col4a1(gene name)|psi-mi:Col4a1(display_short)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721992|imex:IM-17969-9|dip:DIP-189529E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_723044.1|refseq:NP_723045.1|refseq:NP_723046.1|flybase:FBgn0000299|dip:DIP-59819N|ensemblmetazoa:FBgn0000299(gene)|ensemblmetazoa:FBtr0079001(transcript)|ensemblmetazoa:FBtr0079002(transcript)|ensemblmetazoa:FBtr0079003(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007391"(dorsal closure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035848"(oviduct morphogenesis)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048621"(post-embryonic digestive tract morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:pmVLw1fJsIe0Zm4vtQN3gdv/EB87227	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:oAxzRTQ63EYZZNFBNmg9Q+iSJEc	false	binding-associated region:1546-1779|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O18407	uniprotkb:P07713	intact:EBI-15721782	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721898|imex:IM-17969-5|dip:DIP-189533E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:KAfE6yGF5mHH/2Xw5v267lY3XkM	false	binding-associated region:1505-1761|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O18407	uniprotkb:Q24025	intact:EBI-15721782	intact:EBI-184947|uniprotkb:Q9VXS7|uniprotkb:B7FNI9|ensemblmetazoa:FBpp0073879|ensemblmetazoa:FBpp0304148|ensemblmetazoa:FBpp0309304	psi-mi:o18407_drome(display_long)|uniprotkb:vkg(gene name)|psi-mi:vkg(display_short)|uniprotkb:DmColA2(gene name synonym)|uniprotkb:CG16858(orf name)	psi-mi:sog_drome(display_long)|uniprotkb:sog(gene name)|psi-mi:sog(display_short)|uniprotkb:CG9224(orf name)|uniprotkb:Short gastrulation protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15721898|imex:IM-17969-5|dip:DIP-189533E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0061327"(anterior Malpighian tubule development)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|flybase:FBgn0016075|dip:DIP-59818N	refseq:NP_476736.1|flybase:FBgn0003463|refseq:NP_001259576.1|refseq:NP_001259578.1|dip:DIP-20760N|ensemblmetazoa:FBgn0003463(gene)|ensemblmetazoa:FBtr0074063(transcript)|ensemblmetazoa:FBtr0331760(transcript)|ensemblmetazoa:FBtr0340346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0035271"(ring gland development)|go:"GO:0035592"(establishment of protein localization to extracellular region)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0061328"(posterior Malpighian tubule development)|go:"GO:0110107"(regulation of imaginal disc-derived wing vein specification)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR010895(CHRD)|interpro:IPR016353(Chordin)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:7xC0Ya5P70L5hjM/U+s6LCmz6807227	rogid:KC34gvwDW/5LKdgJ3UpuOFZiZUg7227	rigid:KAfE6yGF5mHH/2Xw5v267lY3XkM	false	binding-associated region:1505-1761|glutathione s tranferase tag:n-n	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P08120	uniprotkb:P07713	intact:EBI-109669|uniprotkb:A4V070|uniprotkb:Q9VMV4|ensemblmetazoa:FBpp0078640|ensemblmetazoa:FBpp0078641|ensemblmetazoa:FBpp0078642	intact:EBI-499422|uniprotkb:P91651|uniprotkb:Q6AWM1|uniprotkb:Q8I0M7|uniprotkb:Q8ITK4|uniprotkb:Q9VQC6|uniprotkb:A4V009|ensemblmetazoa:FBpp0077451|ensemblmetazoa:FBpp0077452|ensemblmetazoa:FBpp0077453|ensemblmetazoa:FBpp0077455	psi-mi:co4a1_drome(display_long)|uniprotkb:Cg25C(gene name synonym)|uniprotkb:Collagen type IV alpha 1(gene name synonym)|uniprotkb:DCg1(gene name synonym)|uniprotkb:CG4145(orf name)|uniprotkb:Col4a1(gene name)|psi-mi:Col4a1(display_short)	psi-mi:deca_drome(display_long)|uniprotkb:dpp(gene name)|psi-mi:dpp(display_short)|uniprotkb:CG9885(orf name)	psi-mi:"MI:0096"(pull down)	Wang et al. (2008)	pubmed:18701888|doi:10.1038/nature07214|imex:IM-17969	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15722013|imex:IM-17969-10|dip:DIP-189529E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_723044.1|refseq:NP_723045.1|refseq:NP_723046.1|flybase:FBgn0000299|dip:DIP-59819N|ensemblmetazoa:FBgn0000299(gene)|ensemblmetazoa:FBtr0079001(transcript)|ensemblmetazoa:FBtr0079002(transcript)|ensemblmetazoa:FBtr0079003(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007391"(dorsal closure)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035848"(oviduct morphogenesis)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0048621"(post-embryonic digestive tract morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0071711"(basement membrane organization)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954	refseq:NP_477311.1|refseq:NP_722810.1|refseq:NP_722811.1|refseq:NP_722813.1|flybase:FBgn0000490|dip:DIP-19N|ensemblmetazoa:FBgn0000490(gene)|ensemblmetazoa:FBtr0077771(transcript)|ensemblmetazoa:FBtr0077772(transcript)|ensemblmetazoa:FBtr0077773(transcript)|ensemblmetazoa:FBtr0077775(transcript)|go:"GO:0001715"(ectodermal cell fate specification)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007281"(germ cell development)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007313"(maternal specification of dorsal/ventral axis, oocyte, soma encoded)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007391"(dorsal closure)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007442"(hindgut morphogenesis)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007458"(progression of morphogenetic furrow involved in compound eye morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007498"(mesoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007516"(hemocyte development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0007378"(amnioserosa formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010002"(cardioblast differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016015"(morphogen activity)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0035156"(fusion cell fate specification)|go:"GO:0035158"(regulation of tube diameter, open tracheal system)|go:"GO:0035168"(larval lymph gland hemocyte differentiation)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0035215"(genital disc development)|go:"GO:0035217"(labial disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035224"(genital disc anterior/posterior pattern formation)|go:"GO:0035263"(genital disc sexually dimorphic development)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0036098"(male germ-line stem cell population maintenance)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048542"(lymph gland development)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048636"(positive regulation of muscle organ development)|go:"GO:0060323"(head morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061320"(pericardial nephrocyte differentiation)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0061352"(cell chemotaxis involved in Malpighian tubule morphogenesis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0098898"(dense core granule lumen)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-DME-114608|reactome:R-DME-201451|reactome:R-DME-381426|go:"GO:0009950"(dorsal/ventral axis specification)|reactome:R-DME-8957275	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:pmVLw1fJsIe0Zm4vtQN3gdv/EB87227	rogid:ahdsWqw3mytdXdl3x3PIVupVxEc7227	rigid:oAxzRTQ63EYZZNFBNmg9Q+iSJEc	false	sufficient binding region:1546-1779|glutathione s tranferase tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)