#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P03433 uniprotkb:P03431 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Obayashi et al. (2008) pubmed:18660801|doi:10.1038/nature07225|imex:IM-17991 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15717946|imex:IM-17991-1|dip:DIP-143225E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rigid:ynoxQqQMPp/5sEqNv8ToothsjbU false binding-associated region:239-716 binding-associated region:1-81 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P03433 uniprotkb:P03431 intact:EBI-2547616|uniprotkb:A4GXH3|uniprotkb:Q20N31|uniprotkb:Q8JUU6 intact:EBI-2547514|uniprotkb:A4GXH1|uniprotkb:Q20N30|uniprotkb:Q8JUU7 psi-mi:pa_i34a1(display_long)|uniprotkb:PA(gene name)|psi-mi:PA(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P2(gene name synonym) psi-mi:rdrp_i34a1(display_long)|uniprotkb:PB1(gene name)|psi-mi:PB1(display_short)|uniprotkb:Polymerase basic protein 1(gene name synonym)|uniprotkb:RNA-directed RNA polymerase subunit P1(gene name synonym) psi-mi:"MI:0096"(pull down) Obayashi et al. (2008) pubmed:18660801|doi:10.1038/nature07225|imex:IM-17991 taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") taxid:211044(i34a1)|taxid:211044("Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15717967|imex:IM-17991-2|dip:DIP-143225E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR001009(RNA-directed RNA polymerase, P2 subunit)|interpro:IPR037534|interpro:IPR038372|rcsb pdb:2ZNL|rcsb pdb:4YYL|rcsb pdb:4ZHZ|rcsb pdb:4ZI0|rcsb pdb:4ZQQ|rcsb pdb:5FDD|rcsb pdb:5FDG|rcsb pdb:5I13|rcsb pdb:5JHT|rcsb pdb:5JHV|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905|go:"GO:0075526"(cap snatching)|refseq:NP_040986.1|dip:DIP-43996N|mint:P03433 go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0019083"(viral transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0031904"(endosome lumen)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039694"(viral RNA genome replication)|interpro:IPR001407(RNA-dependent RNA polymerase, PB1 subunit, Influenza-ype)|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|rcsb pdb:2ZNL|rcsb pdb:2ZTT|rcsb pdb:3A1G|go:"GO:0042025"(host cell nucleus)|refseq:NP_040985.1|reactome:R-HSA-168255|reactome:R-HSA-168271|reactome:R-HSA-168275|reactome:R-HSA-168288|reactome:R-HSA-168298|reactome:R-HSA-168302|reactome:R-HSA-168303|reactome:R-HSA-168325|reactome:R-HSA-168330|reactome:R-HSA-168333|dip:DIP-56974N|reactome:R-HSA-168336|reactome:R-HSA-192814|reactome:R-HSA-192823|reactome:R-HSA-192869|reactome:R-HSA-192905 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:vmY21RjtALOteYkDRockgEeKLss211044 rogid:57q1RvwNj9GxHcwpri3Kb7yBFm8211044 rigid:ynoxQqQMPp/5sEqNv8ToothsjbU false sufficient binding region:657-716|mutation disrupting interaction:636-636|mutation disrupting interaction:640-640|mutation disrupting interaction:666-666|mutation disrupting interaction:706-706 binding-associated region:1-14|glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)