#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Jones et al. (2008)	pubmed:18599299|doi:10.1016/j.str.2008.06.005|imex:IM-9297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15712557|imex:IM-9297-3|dip:DIP-87775E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	psi-mi:"MI:0465"(dip)	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	binding-associated region:19-225	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q969J5-3	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-15712576|ensembl:ENSP00000340920	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:q969j5-3(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:CRF2-10S(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jones et al. (2008)	pubmed:18599299|doi:10.1016/j.str.2008.06.005|imex:IM-9297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15712588|imex:IM-9297-1|dip:DIP-87777E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSG00000164485(gene)|ensembl:ENST00000339602(transcript)|intact:EBI-8591719(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:HAaUboi1AxsP/vvBtcz3itBVE6s9606	rigid:89fVRANRqAmqU35Xf2ScJ7TvGro	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jones et al. (2008)	pubmed:18599299|doi:10.1016/j.str.2008.06.005|imex:IM-9297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15712605|imex:IM-9297-2|dip:DIP-87775E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	psi-mi:"MI:0465"(dip)	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	binding-associated region:19-225	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q969J5-2	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-15712624|ensembl:ENSP00000296979	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:q969j5-2(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:CRF2-10(isoform synonym)|uniprotkb:CRF2-s1-short(isoform synonym)|uniprotkb:Short(isoform synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Jones et al. (2008)	pubmed:18599299|doi:10.1016/j.str.2008.06.005|imex:IM-9297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15712638|imex:IM-9297-4|dip:DIP-87776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSG00000164485(gene)|ensembl:ENST00000349184(transcript)|intact:EBI-8591719(isoform-parent)|uniprotkb:Q969J5-2(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:JZJMHZvTIH8S1djVp3ndBoz0uig9606	rigid:PXr6IzT1uwt+TEEDorF9TnzCMaI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)