#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15797	uniprotkb:P17844	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708703|imex:IM-17999-1|dip:DIP-189589E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:9YBmwhwYQWQQf0S/t/I8GT+w954	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P84022	uniprotkb:Q9NRR4	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708760|imex:IM-17999-4|dip:DIP-189593E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rigid:S56sld4EN5LjcKbPHeLU+kosYI8	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P84022	uniprotkb:P17844	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708760|imex:IM-17999-4|dip:DIP-189593E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:S56sld4EN5LjcKbPHeLU+kosYI8	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P84022	uniprotkb:P17844	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708741|imex:IM-17999-3|dip:DIP-189595E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:OJTVdIuIfm7ZJY9+o0WO2TLSuOA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRR4	uniprotkb:P17844	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708722|imex:IM-17999-2|dip:DIP-189591E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:OLMi6Hondsit6LddApJMnd9+yz4	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15797	uniprotkb:P17844	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708780|imex:IM-17999-5|dip:DIP-189589E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:9YBmwhwYQWQQf0S/t/I8GT+w954	false	glutathione s tranferase tag:n-n|sufficient binding region:271-465	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:Q9NRR4	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708801|imex:IM-17999-6|dip:DIP-189592E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rigid:uWFSWpiRf/evGeuCf4Vp5/YNyoA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15797	uniprotkb:P17844	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708801|imex:IM-17999-6|dip:DIP-189592E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:uWFSWpiRf/evGeuCf4Vp5/YNyoA	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99717	uniprotkb:Q9NRR4	intact:EBI-6391136|ensembl:ENSP00000426696|ensembl:ENSP00000441954|ensembl:ENSP00000446474|uniprotkb:O14688|uniprotkb:Q15798|uniprotkb:Q9UQA1	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	psi-mi:smad5_human(display_long)|uniprotkb:SMAD5(gene name)|psi-mi:SMAD5(display_short)|uniprotkb:MADH5(gene name synonym)|uniprotkb:JV5-1(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708880|imex:IM-17999-10|dip:DIP-189594E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113658(gene)|ensembl:ENST00000509297(transcript)|ensembl:ENST00000545620(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000545279(transcript)|go:"GO:0007281"(germ cell development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:6FZS|rcsb pdb:6TCE|reactome:R-HSA-201451|go:"GO:0009653"(anatomical structure morphogenesis)|refseq:NP_001001419.1|refseq:NP_001001420.1|refseq:NP_005894.3|refseq:XP_016864959.1|dip:DIP-57571N	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:BEWuj4dPLDfCbpg7lK5k2n+G9tM9606	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rigid:mqfg9Qnmdk836vt83gaD76cPfvI	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99717	uniprotkb:P17844	intact:EBI-6391136|ensembl:ENSP00000426696|ensembl:ENSP00000441954|ensembl:ENSP00000446474|uniprotkb:O14688|uniprotkb:Q15798|uniprotkb:Q9UQA1	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad5_human(display_long)|uniprotkb:SMAD5(gene name)|psi-mi:SMAD5(display_short)|uniprotkb:MADH5(gene name synonym)|uniprotkb:JV5-1(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708880|imex:IM-17999-10|dip:DIP-189594E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113658(gene)|ensembl:ENST00000509297(transcript)|ensembl:ENST00000545620(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000545279(transcript)|go:"GO:0007281"(germ cell development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:6FZS|rcsb pdb:6TCE|reactome:R-HSA-201451|go:"GO:0009653"(anatomical structure morphogenesis)|refseq:NP_001001419.1|refseq:NP_001001420.1|refseq:NP_005894.3|refseq:XP_016864959.1|dip:DIP-57571N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:BEWuj4dPLDfCbpg7lK5k2n+G9tM9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:mqfg9Qnmdk836vt83gaD76cPfvI	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99717	uniprotkb:P17844	intact:EBI-6391136|ensembl:ENSP00000426696|ensembl:ENSP00000441954|ensembl:ENSP00000446474|uniprotkb:O14688|uniprotkb:Q15798|uniprotkb:Q9UQA1	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:smad5_human(display_long)|uniprotkb:SMAD5(gene name)|psi-mi:SMAD5(display_short)|uniprotkb:MADH5(gene name synonym)|uniprotkb:JV5-1(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708861|imex:IM-17999-9|dip:DIP-189596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113658(gene)|ensembl:ENST00000509297(transcript)|ensembl:ENST00000545620(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000545279(transcript)|go:"GO:0007281"(germ cell development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:6FZS|rcsb pdb:6TCE|reactome:R-HSA-201451|go:"GO:0009653"(anatomical structure morphogenesis)|refseq:NP_001001419.1|refseq:NP_001001420.1|refseq:NP_005894.3|refseq:XP_016864959.1|dip:DIP-57571N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:BEWuj4dPLDfCbpg7lK5k2n+G9tM9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:7ysg47ypY59Ah8mBOBIJWUfMOkI	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRR4	uniprotkb:Q15797	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708840|imex:IM-17999-8|dip:DIP-189590E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rigid:q9R+tr+RvVhq/FNBZzlm1nwNTis	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17844	uniprotkb:Q9NRR4	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708821|imex:IM-17999-7|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17844	uniprotkb:Q99717	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	intact:EBI-6391136|ensembl:ENSP00000426696|ensembl:ENSP00000441954|ensembl:ENSP00000446474|uniprotkb:O14688|uniprotkb:Q15798|uniprotkb:Q9UQA1	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:smad5_human(display_long)|uniprotkb:SMAD5(gene name)|psi-mi:SMAD5(display_short)|uniprotkb:MADH5(gene name synonym)|uniprotkb:JV5-1(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708821|imex:IM-17999-7|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	ensembl:ENSG00000113658(gene)|ensembl:ENST00000509297(transcript)|ensembl:ENST00000545620(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000545279(transcript)|go:"GO:0007281"(germ cell development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:6FZS|rcsb pdb:6TCE|reactome:R-HSA-201451|go:"GO:0009653"(anatomical structure morphogenesis)|refseq:NP_001001419.1|refseq:NP_001001420.1|refseq:NP_005894.3|refseq:XP_016864959.1|dip:DIP-57571N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rogid:BEWuj4dPLDfCbpg7lK5k2n+G9tM9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17844	uniprotkb:Q15797	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708821|imex:IM-17999-7|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRR4	uniprotkb:Q99717	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-6391136|ensembl:ENSP00000426696|ensembl:ENSP00000441954|ensembl:ENSP00000446474|uniprotkb:O14688|uniprotkb:Q15798|uniprotkb:Q9UQA1	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:smad5_human(display_long)|uniprotkb:SMAD5(gene name)|psi-mi:SMAD5(display_short)|uniprotkb:MADH5(gene name synonym)|uniprotkb:JV5-1(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708900|imex:IM-17999-11|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	ensembl:ENSG00000113658(gene)|ensembl:ENST00000509297(transcript)|ensembl:ENST00000545620(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|ensembl:ENST00000545279(transcript)|go:"GO:0007281"(germ cell development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|rcsb pdb:6FZS|rcsb pdb:6TCE|reactome:R-HSA-201451|go:"GO:0009653"(anatomical structure morphogenesis)|refseq:NP_001001419.1|refseq:NP_001001420.1|refseq:NP_005894.3|refseq:XP_016864959.1|dip:DIP-57571N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:BEWuj4dPLDfCbpg7lK5k2n+G9tM9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRR4	uniprotkb:Q15797	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708900|imex:IM-17999-11|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NRR4	uniprotkb:P17844	intact:EBI-528367|uniprotkb:Q7Z5V2|uniprotkb:Q86YH0|uniprotkb:Q9NW73|uniprotkb:Q9Y2V9|uniprotkb:Q9Y4Y0|intact:EBI-10973107|uniprotkb:E7EMP9|ensembl:ENSP00000339845|ensembl:ENSP00000425979	intact:EBI-351962|uniprotkb:O75681|uniprotkb:Q53Y61|uniprotkb:B4DLW8|uniprotkb:E7ETL9|uniprotkb:B5BU21|uniprotkb:D3DU32|ensembl:ENSP00000225792|ensembl:ENSP00000403085|ensembl:ENSP00000463168|ensembl:ENSP00000464337|ensembl:ENSP00000504794	psi-mi:rnc_human(display_long)|uniprotkb:Ribonuclease III(gene name synonym)|uniprotkb:DROSHA(gene name)|psi-mi:DROSHA(display_short)|uniprotkb:p241(gene name synonym)|uniprotkb:RNASEN(gene name synonym)|uniprotkb:RN3(gene name synonym)|uniprotkb:RNASE3L(gene name synonym)|uniprotkb:Protein Drosha(gene name synonym)	psi-mi:ddx5_human(display_long)|uniprotkb:HLR1(gene name synonym)|uniprotkb:DDX5(gene name)|psi-mi:DDX5(display_short)|uniprotkb:HELR(gene name synonym)|uniprotkb:G17P1(gene name synonym)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davis et al. (2008)	pubmed:18548003|doi:10.1038/nature07086|imex:IM-17999	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15708900|imex:IM-17999-11|dip:DIP-189597E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093882.1|refseq:NP_037367.3|refseq:XP_005248348.1|refseq:XP_005248351.1|ensembl:ENSG00000113360(gene)|ensembl:ENST00000344624(transcript)|ensembl:ENST00000511367(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070877"(microprocessor complex)|go:"GO:0070878"(primary miRNA binding)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000999(Ribonuclease III)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044442|rcsb pdb:2KHX|rcsb pdb:2NA2|rcsb pdb:5B16|rcsb pdb:6LXD|rcsb pdb:6LXE|rcsb pdb:6V5B|rcsb pdb:6V5C|reactome:R-HSA-203927|dip:DIP-33300N	refseq:NP_004387.1|refseq:NP_001307524.1|refseq:NP_001307525.1|dip:DIP-29844N|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P17844|rcsb pdb:3FE2|rcsb pdb:4A4D|reactome:R-HSA-3899300|reactome:R-HSA-72163|reactome:R-HSA-9018519|reactome:R-HSA-9682706|reactome:R-HSA-9694686|ensembl:ENST00000225792(transcript)|ensembl:ENST00000450599(transcript)|ensembl:ENST00000577922(transcript)|ensembl:ENST00000585111(transcript)|ensembl:ENST00000676785(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009299"(mRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|ensembl:ENSG00000108654(gene)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:vHfmSHxD1M/Sh4dbo2S7FBaE+eQ9606	rogid:BlaILQg90jqkI5+DdA0k5YTCGOo9606	rigid:M0/AiMeQgwPXFfzLYeagbYQwPj8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)